Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Article, Chemistry – A European Journal called Novel Base-Free Catalytic Wittig Reaction for the Synthesis of Highly Functionalized Alkenes, Author is Schirmer, Marie-Luis; Adomeit, Sven; Spannenberg, Anke; Werner, Thomas, the main research direction is highly functionalized alkene preparation diastereoselective synthesis; organocatalytic Wittig reaction olefin aldehyde Bronsted acid additive; Wittig reactions; homogeneous catalysis; olefination; organocatalysis; ylides.Recommanded Product: 1-(tert-Butyl)-1H-pyrrole-2,5-dione.
A highly efficient catalyst system for base-free catalytic Wittig reactions has been developed and optimized. Initially, several potential (pre)catalysts as well as different silanes as reducing agents were screened. A system based on a readily available phosphine oxide as precatalyst and trimethoxy silane as reducing agent proved to be optimal. The effect of various Bronsted acidic additives was studied. Subsequently, the reaction conditions were optimized and standard reaction conditions were determined Under these conditions the scope of this new protocol was evaluated. Nine activated olefins and 33 aldehydes were converted into 42 highly functionalized alkenes. Notably, aromatic, aliphatic as well as heteroaromatic aldehydes could be converted, giving the desired products in isolated yields up to 99 % and with good to excellent E/Z selectivities. These results underline the remarkable efficiency of this protocol considering the complexity of the reaction mixture and the four reaction steps that proceed in parallel in one pot.
After consulting a lot of data, we found that this compound(4144-22-3)Recommanded Product: 1-(tert-Butyl)-1H-pyrrole-2,5-dione can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics