Reference of 139512-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 0.37 g (1 mmol) of compound 2 and 0.16 g (1 mmol) of 4-chloro,5-fluoro-o-phenylenediamine in 4 mL of polyphosphoric acid was stirred at 200 C. for 4 h and poured into 60 mL of dilute NH4OH. It was extracted with three 60 mL portions of ethyl acetate. The combined organic extracts were washed with 60 mL of brine and concentrated. The residue was chromatographed eluting with a gradient of from 2 to 10% methanol (MeOH) in dichloromethane (DCM) plus 1% NH4OH to give 0.06 g of compound 3a and 0.14 g of compound 3b. 3a: Calcd m/z for C26H23BrFN3.H+=478; found m/z=478. 3b: Calcd m/z for C26H22BrClFN3.H+=512; found m/z=512.
The chemical industry reduces the impact on the environment during synthesis 4-Chloro-5-fluorobenzene-1,2-diamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Schering Corporation; US2005/49269; (2005); A1;,
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