The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,3′-Diindolylmethane(SMILESS: C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4,cas:1968-05-4) is researched.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 in relation to this compound, is published in Molecular Immunology. Let’s take a look at the latest research on this compound (cas:1968-05-4).
Atopic dermatitis is a severe, chronic relapsing inflammatory disease of the skin with family clustering. It is characterized into acute phase, which is dominated by T helper 2-type immune responses, and chronic phase, which is dominated by T helper 1-type immune responses. Studies have shown that 3,3-diindolylmethane not only has antitumor effects but also can relieve symptoms of inflammatory diseases by inhibiting the nuclear factor-κB signaling pathway and regulating T cell differentiation. To study the effect of 3,3-diindolylmethane on atopic dermatitis and the underlying mechanism, a mouse model of acute atopic dermatitis was established using 2,4-dinitrofluorobenzene. After i.p. injection of 3,3-diindolylmethane, skin erythema and edema in mice were significantly alleviated. Furthermore, 3,3-diindolylmethane reduced immune activation, probably by inhibiting the secretion of thymic stromal lymphopoietin by keratinocytes. 3,3-Diindolylmethane also promoted the differentiation of regulatory T cells and inhibited the activation of T helper 2 and T helper 17 cells to reduce atopic dermatitis-related immune responses. However, it showed no significant effect on the differentiation of T helper 1 cells. These results indicate that 3,3-diindolylmethane has a significant inhibitory effect on T helper 2 cells in the acute phase of atopic dermatitis. Our findings may provide not only more insights into the pathol. mechanism of AD, but also a new candidate medicine for it.
The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 also mentions many details about this compound(1968-05-4)Recommanded Product: 3,3′-Diindolylmethane, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics