Reddy, Raju Jannapu’s team published research in Asian Journal of Organic Chemistry in 2019 | 128-09-6

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Reddy, Raju Jannapu; Shankar, Angothu; Kumari, Arram Haritha published the artcile< An Efficient Sequential One-Pot Approach for the Synthesis of C3-Functionalized Imidazo[1,2-a]pyridines under Transition-Metal Free Conditions>, HPLC of Formula: 128-09-6, the main research area is imidazopyridine preparation; bromomethyl ketone aminopyridine thiosulfonate sulfenylation.

A metal-free sequential one-pot three-component protocol is described for the synthesis of C3-functionalized imidazo[1,2-a]pyridines. A successive construction of imidazo[1,2-a]pyridine I (R = 4-MeC6H4, 2-naphthyl, 2-thienyl, etc.; R1 = SMe, naphthalen-1-ylsulfanyl, pyridin-2-ylsulfanyl, etc.; X = H, 6-Br, 6-Cl, 7-Me, 8-Me) followed by iodine-catalyzed sulfenylation has been achieved in a one-pot operation from readily available α-bromomethyl ketones RC(O)CH2Br, 2-aminopyridines II and thiosulfonates R1S(O)2Ar (Ar = C6H5, 1-naphthyl, 2-thienyl, etc.). An immense array of 3-sulfenylimidazo[1,2-a]pyridines I was obtained in good to high yields. Also, the method is extended for the synthesis of C3-halogenated imidazo[1,2-a]pyridines I (R1 = Br, Cl) using sodium halides NaY in the presence of K2S2O8. Notably, the reaction between α-bromomethyl ketones and 2-aminopyridines in the presence of K2S2O8 to yields 3-bromo-2-aryl-imidazo[1,2-a]pyridines I (R1 = Br), thus implying α-bromomethyl ketones to be served as brominating agent. Overall, the present sequential one-pot protocol is straightforward, operationally simple, tolerates a broad range of functional groups, and is reliable for gram-scale experiments

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics