Jatav, Varsha; Kashaw, Sushil; Mishra, Pradeep published the artcile< Synthesis, antibacterial and antifungal activity of some novel 3-[5-(4-substituted phenyl) 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones>, Application of C8H6ClN3S, the main research area is aryl thiadiazolyl styryl quinazolinone preparation antibacterial antifungal activity.
A series of novel 3-[5-substituted phenyl-1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones, e.g., I, were synthesized and evaluated for antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCC number 96), Bacillus subtilis (MTCC number 619), Pseudomonas aeruginosa (MTCC number 424) and Escherichia coli (MTCC number 40) and antifungal activity against Aspergillus niger, Candida albicans and Fusarium oxysporum. The cup-plate method was employed to determine the min. inhibitory concentration (MIC) value of the compounds Some of the compounds exhibited activity comparable to Norfloxacin. The present report reveals that synthesized 2-styryl-quinazoline-4(3H)-one exhibited better antibacterial than antifungal activity.
Medicinal Chemistry Research published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Application of C8H6ClN3S.
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