Lindsley, Craig W.; Zhao, Zhijian; Leister, William H.; O’Brien, Julie; Lemaire, Wei; Williams, David L. Jr.; Chen, Tsing-Bau; Chang, Raymond S. L.; Burno, Maryann; Jacobson, Marlene A.; Sur, Cyrille; Kinney, Gene G.; Pettibone, Douglas J.; Tiller, Philip R.; Smith, Sheri; Tsou, Nancy N.; Duggan, Mark E.; Conn, P. Jeffrey; Hartman, George D. published the artcile< Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides>, Quality Control of 162046-61-9, the main research area is antipsychotic piperidinylmethylbenzamide preparation SAR glycine transporter.
An iterative analog library synthesis approach was employed to develop SAR for the title compounds Analog I was thus identified as a novel, centrally active GlyT1 inhibitor. I enhanced prepulse inhibition in a rodent behavioral model sensitive to antipsychotic treatment.
ChemMedChem published new progress about Antipsychotics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Quality Control of 162046-61-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics