Liu, Jiwen; Fu, Zice; Wang, Yingcai; Schmitt, Mike; Huang, Alan; Marshall, Derek; Tonn, George; Seitz, Lisa; Sullivan, Tim; Lucy Tang, H.; Collins, Tassie; Medina, Julio published the artcile< Discovery and optimization of CRTH2 and DP dual antagonists>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is phenylacetic acid derivative preparation prostanoid CRTH2 DP dual antagonist.
A series of phenylacetic acid derivatives was discovered as CRTH2 antagonists. Modification of the series led to compounds that are also antagonists of DP. Since activation of CRTH2 and DP are believed to play key roles in mediating responses of asthma and other immune diseases, this series was optimized to increase the dual antagonistic activities and improve pharmacokinetic properties. These efforts led to selection of AMG 009 as a clin. candidate.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiasthmatics. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics