Rajan, Ida Angel Priya Samuel; Subramani, Muthuraman; Pushparathinam, Gopinath; Rajendran, Saravanakumar published the artcile< Environmentally Benign Transamidation Protocol for Weakly Nucleophilic Aromatic Amines with N-Acyl-2-piperidinones: Catalyst-, Additive-, Base- and Solvent-Free Condition>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is amide chemoselective green preparation; amine acyl piperidinone transamidation.
Transamidation of weakly nucleophilic aromatic amines was achieved under melt conditions and in absence of catalyst, activating agent, base and solvent to obtain amides RC(O)NHR1 [R = Me, Ph, 4-ClC6H4, etc.; R1 = 4-MeC6H4, 4-FC6H4, 2-OHC6H4, etc.]. Chemoselectivity of the protocol was demonstrated with transamidation of aniline-bearing protic carboxylic acid group and wide range of anilines. Broad applicability of the process was demonstrated with the synthesis of bioactive natural product amide, Avenanthranamide-A. Byproduct was isolated for re-use in synthesis of starting amide, manifests atom economy and sustainability of the protocol. The developed protocol was environmentally benign, operationally simple yet versatile for protection-deprotection free synthesis of amides, peptides and amide-based drugs.
Asian Journal of Organic Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics