Related Products of 363-51-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 363-51-9, name is 2-Chloro-6-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 4-bromo-2-butoxy-5-fluorobenzoic acid (Intermediate 2, 1.36 g, 4.67 mmol) and catalyticDMF in anhydrous DCM (25 mL) was added oxalyl chloride (490 ml, 5.6 mmol) dropwise. The resulting mixture wasstirred for 1 h and concentrated under reduced pressure. A solution of the residue in anhydrous DCM (20 mL) was addeddropwise to a stirred solution of 2-chloro-6-fluoroaniline (750 mg, 5.15 mmol) and triethylamine (720 ml, 5.2 mmol) inanhydrous DCM (30 mL). Following complete addition, the mixture stirred for 1 h. The mixture was concentrated underreduced pressure. The residue was dissolved in ethanol (15 mL) and precipitated by slow addition of water (30 mL).The solid was collected on a filter, washed with water and dried in a vacuum oven to yield 1.73 g (88 % yield) of thedesired product.LC-MS: Rt = 1.55 min; MS (ESIpos): m/z = 418 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 0.787 (0.48), 0.889 (6.64), 0.908 (16.00), 0.926 (7.83), 1.390 (0.52), 1.408(1.83), 1.427 (3.10), 1.446 (3.07), 1.464 (1.83), 1.483 (0.50), 1.731 (0.76), 1.747 (2.12), 1.767 (2.57), 1.784 (2.05), 1.801(0.67), 2.518 (3.81), 2.523 (2.64), 4.165 (2.33), 4.181 (4.62), 4.197 (2.31), 7.329 (0.79), 7.348 (1.90), 7.367 (1.26), 7.372(1.43), 7.380 (1.00), 7.395 (0.95), 7.400 (1.79), 7.414 (1.86), 7.421 (1.38), 7.433 (4.14), 7.438 (3.57), 7.453 (1.07), 7.458(0.93), 7.579 (2.69), 7.593 (2.74), 7.612 (3.05), 7.634 (2.88), 9.836 (4.40).
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-6-fluoroaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Bayer AG; Gradl, Stefan, Nikolaus; Niehues, Michael; Halfbrodt, Wolfgang; (43 pag.)EP3553052; (2019); A1;,
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