Category: 1005-56-7

Synthetic Route of 1005-56-7, The chemical industry reduces the impact on the environment during synthesis 1005-56-7, name is O-Phenyl carbonochloridothioate, I believe this compound will play a more active role in future production and life.

To a solution of cholesterol (863 mg, 2.23 mmol) in CH2Cl2 (10 mL) were added pyridine (485 muL, 6.00 mmol) and phenyl chlorothionoformate (277 muL, 2.00 mmol) (For other substrates, CH3CN was used in place of CH2Cl2.). The mixture was stirred at room temperature for 50 min and diluted with EtOAc. The solution was washed with brine and dried over anhydrous MgSO4. After concentration, the residue was purified by flash chromatography on silica gel (hexane?hexane/EtOAc=10/1) to give thiocarbonate 5b (1.04 g, 1.99 mmol, 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, O-Phenyl carbonochloridothioate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kobayashi, Shoji; Kuroda, Hiroyuki; Ohtsuka, Yuta; Kashihara, Takashi; Masuyama, Araki; Watanabe, Kiyoshi; Tetrahedron; vol. 69; 10; (2013); p. 2251 – 2259;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the dibromofluoroalcohol (1.0 equiv.), acid chloride (1.1-1.5 equiv.) and triethylamine (2.2-3.0 equiv.) in THF was stirred for 1 h at 0 C, then for additional appropriate period (usually 2-3 h) at room temperature. As in the cases of 1e, 1f, 8c-e catalytic amount of 4-dimethylaminopyridine was also added. Usual workup (addition of water, extraction with diethyl ether or ethyl acetate, dried over MgSO4) followed by purification by silica gel column chromatography (mixture of hexane and EtOAc as eluent) gave the corresponding ester.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-Phenyl carbonochloridothioate, its application will become more common.

Reference:
Article; Saito, Akio; Tojo, Manabu; Yanai, Hikaru; Wada, Fukiko; Nakagawa, Muga; Okada, Midori; Sato, Azusa; Okatani, Rieko; Taguchi, Takeo; Journal of Fluorine Chemistry; vol. 133; (2012); p. 38 – 51;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 1005-56-7, These common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Phenyl chlorothionoformate (345 mg, 2.0 mmol), amine 2 (4.0 mmol) and water (15 mL) were added successively to a 50 mL round-bottom flask. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC). After the reaction was complete, the solid was filtered off, washed with 10% HCl (2 ¡Á 20 mL) and deionised water(2 ¡Á 20 mL), and dried under vacuum to give the pure thiocarbamates 3. All products are known compounds and were identified by comparison of their physical and spectral data with those reported inthe literature.28

The synthetic route of 1005-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Zhengyi; Chen, Yuan; Yin, Yue; Wang, Zhiming; Sun, Xiaoqiang; Journal of Chemical Research; vol. 40; 11; (2016); p. 670 – 673;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 1005-56-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1005-56-7, name is O-Phenyl carbonochloridothioate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of compound 14 (200 mg, 0.47 mmol) in THF (5 mL), was added nBuLi (370 muL, 0.59 mmol, 1 .6 M in hexanes) at -78 C. The resulting solution was stirred at 78 C for 30 min before a solution of O-phenyl chlorothionoformate (100 muL, 125 mg, 0.723 mmol) in THF (1 mL) was added. The resulting mixture was allowed to warm to 0 C and stirred for 3 h before it was quenched with a saturated solution of NH4CI (10 mL) and diluted with CH2CI2 (10 mL). The layers were separated, and the aqueous layer was extracted with CH2CI2 (4 x 5 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, hexanes: EtOAc 10: 1 ? 5: 1 ) to give compound 15 (243 mg, 92%; mixture of inseparable diastereoisomers) as a yellow oil. (0320) [00240] 1 H NMR (400 MHz, CDCI3) delta = 8.16 (d, J = 7.4 Hz, 1 H), 7.61 – 7.49 (m, 5H), 7.46 – 7.40 (m, 3H), 7.39 – 7.32 (m, 5H), 7.30 – 7.23 (m, 3H), 7.10 (dq J = 1 1 .0, 6.6 Hz, 1 H), 6.82 – 6.77 (m, 2H), 5.28 (s, 2H), 4.68 (d, J = 1 1 .0 Hz, 1 H), 3.12 (s, 3H); 19F NMR (376 MHz, CDCI3) delta = -78.87 (d, J = 6.6 Hz, 3F).

The synthetic route of O-Phenyl carbonochloridothioate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO; GREIG, Iain; ZANDA, Matteo; TSENG, Chih-Chung; ROSS, Ruth; (134 pag.)WO2016/29310; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1005-56-7, name is O-Phenyl carbonochloridothioate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of O-Phenyl carbonochloridothioate

The pyridine (2.01 mL, 25.03 mmol) andphenyl chlorothionoformate(5.18 mL, 37.52 mmol) were added in the compound 3 (5.0 g, 12.50 mmol) in 50 mL CH2Cl2. The mixture was stirred at room temperature for 3 h. The solution was washed with brine and dried by anhydrous MgSO4. After concentration, the residue was purified by flash chromatography on silica gel (hexane/EtOAc, 4/1) to give thiocarbonate compound (4) (5.23 g, 78)

According to the analysis of related databases, 1005-56-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WENG, Ching-Feng; CHEN, Chin-piao; SHIVAJI, Sulake Rohidas; HUANG, Zi-Ling; (74 pag.)WO2016/37566; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1005-56-7, A common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Phenyl chlorothionoformate (345 mg, 2.0 mmol), amine 2 (4.0 mmol) and water (15 mL) were added successively to a 50 mL round-bottom flask. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC). After the reaction was complete, the solid was filtered off, washed with 10% HCl (2 ¡Á 20 mL) and deionised water(2 ¡Á 20 mL), and dried under vacuum to give the pure thiocarbamates 3. All products are known compounds and were identified by comparison of their physical and spectral data with those reported inthe literature.28

The synthetic route of 1005-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Zhengyi; Chen, Yuan; Yin, Yue; Wang, Zhiming; Sun, Xiaoqiang; Journal of Chemical Research; vol. 40; 11; (2016); p. 670 – 673;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1005-56-7, name is O-Phenyl carbonochloridothioate, A new synthetic method of this compound is introduced below., Safety of O-Phenyl carbonochloridothioate

General procedure: Phenyl chlorothionoformate (345 mg, 2.0 mmol), amine 2 (4.0 mmol) and water (15 mL) were added successively to a 50 mL round-bottom flask. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC). After the reaction was complete, the solid was filtered off, washed with 10% HCl (2 ¡Á 20 mL) and deionised water(2 ¡Á 20 mL), and dried under vacuum to give the pure thiocarbamates 3. All products are known compounds and were identified by comparison of their physical and spectral data with those reported inthe literature.28

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Zhengyi; Chen, Yuan; Yin, Yue; Wang, Zhiming; Sun, Xiaoqiang; Journal of Chemical Research; vol. 40; 11; (2016); p. 670 – 673;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Scheme 1) to 500 mg (1.49mmol) fluorescent dye, 516 mg (2.98mmol) sulfur generation of chlorine phenyl formate (384 mg, 2 . 98mmol) and N, N – diisopropylethylamine (DIPEA) dissolved in 15 ml dichloromethane in, then 25 C stirring reaction under 9h, after steaming and to get the crude product, last-used methylene chloride: methanol=60:1 system carrying out column chromatography separation, get the pure product 647 mg, and the yield is 92

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-Phenyl carbonochloridothioate, its application will become more common.

Reference:
Patent; University of Jinan; Wang, Yawei; Zhang, Meng; Wu, Liu; Liu, Caiyun; Duan, Qingxia; Wang, Zuokai; Zhu, Baocun; (12 pag.)CN106543097; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics