Category: 10061-02-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10061-02-6, name is trans-1,3-Dichloropropene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 10061-02-6

A suspension of 6.66 g (0.06 mol) of (E)-1,3-dichloropropene (3), 13.82 g (0.1 mol) of potassium carbonate, and 2.53 g (0.031 mol) of ethylamine hydrochloride in 75 mL of anhydrous acetonitrile was slowly heated to the boiling point with stirring and was then refluxed until complete conversion of 3 (12-14 h, GLC monitoring). The mixture was cooled and filtered, the precipitate was washed with ethyl acetate, the organic fractions were combined and concentrated, and the product was isolated by vacuum distillation. Yield 4.24 g (73%), bp 89 C (4-5 mm). IR spectrum, nu, cm-1: 2971, 2935,2811, 1635, 1456, 1360, 1285, 1132, 934, 801. 1H NMR spectrum, delta, ppm: 1.03 t (3H, CH3, J =7.2 Hz), 2.50 q (2H, CH3CH2N, J = 7.2 Hz), 3.09 d (4H, CH2CH=, J = 6.8 Hz), 5.93 d.t (2H, CH2CH=, Jtrans = 13.2, 6.8 Hz), 6.12 d (2H, ClCH=, Jtrans = 13.2 Hz). 13C NMR spectrum, deltaC, ppm: 11.94 (CH3), 46.80 (CH3CH2N), 52.74 (2C, CH2CH=), 119.99 (2C, ClCH=), 130.41 (2C, CH2CH=). Mass spectrum, m/z (Irel, %): 193 (5) [M]+, 180 (20), 178 (32), 132 (17), 77 (33), 75 (100), 68 (49), 56 (10), 49 (9), 42 (13), 39 (29).

The synthetic route of 10061-02-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shakhmaev; Sunagatullina, A. Sh.; Zorin; Russian Journal of Organic Chemistry; vol. 53; 6; (2017); p. 832 – 835; Zh. Org. Khim.; vol. 53; 6; (2017); p. 818 – 820,3;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

10061-02-6,Some common heterocyclic compound, 10061-02-6, name is trans-1,3-Dichloropropene, molecular formula is C3H4Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 0.01 mol (1.0 g) of pentane-2,4-dione, 0.001 mol (0.1 g) of sodium butylate, and 60 mL of anhydrous acetonitrile was irradiated at constant stirring for 20 min. The mixture was then cooled to room temperature and was charged with 0.015 mol of the corresponding alkene 4. Next, irradiation was continued for 2 h to complete conversion of pentane-2,4-dione. Upon completion of the reaction (GLC monitoring) the mixture was cooled to room temperature, washed with water, and extracted with chloroform. The organiclayer was dried with potassium carbonate and evaporated. The residue was distilled in a vacuum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10061-02-6, its application will become more common.

Reference:
Letter; Borisova, Yu. G.; Raskildina; Zlotskii; Russian Journal of General Chemistry; vol. 86; 9; (2016); p. 2126 – 2128; Zh. Obshch. Khim.; vol. 86; 9; (2016); p. 1564 – 1566,3;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

10061-02-6, These common heterocyclic compound, 10061-02-6, name is trans-1,3-Dichloropropene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step (b): After the step (a), the reaction system was cooled to 90C, and (1E)-1,3-dichloro-1-propene (192.3 g) in toluene (250 ml) was added. After 2 hours of heating with stirring, the system was cooled to 50C, and water was added to terminate the reaction. The aqueous layer was extracted with diisopropyl ether (IPE), and the extract was combined with the organic layer and washed with water and 5% aqueous NaCl, successively. The solvent was evaporated under reduced pressure to give dimethyl 2-[(2E)-3-chloro-2-propenyl]-2-isopropylmalonate (409.7 g). The product contained 87% (GC purity) of dimethyl 2-[(2E)-3-chloro-2-propenyl]-2-isopropylmalonate and at most 0.5% (measured by GC) of isopropyl bromide, but did not contain the Z-isomer. 1HNMR (400 MHz, CDCl3): 0.98 (d, 6H, J=6.76), 2.31 (m, 1H), 2.62 (dd, 2H, J=1.16, 7.64), 3.73 (s, 6H), 5.89 (dt, 1H, J=7.60, 13.19), 6.01 (dt, 1H, J=1.16, 13.19). 13CNMR (400 MHz, CDCl3): 18.33, 32.41, 35.14, 51.94, 62.06, 119.83, 128.87, 170.66.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10061-02-6.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1571138; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics