Category: 101-20-2

Co-exposure and health risks of several typical endocrine disrupting chemicals in general population in eastern China was written by Wei, Xianping;Hu, Yu;Zhu, Qingqing;Gao, Jia;Liao, Chunyang;Jiang, Guibin. And the article was included in Environmental Research in 2022.SDS of cas: 101-20-2 This article mentions the following:

Human exposure to endocrine disrupting chems. (EDCs) is a health concern due to their wide use and interference with the human endocrine system. Parabens, bisphenols, benzophenones, triclosan (TCC), triclocarban (TCS), and tetrabromobisphenol-A (TBBPA) and its derivatives tetrachlorobisphenol-A (TCBPA) and tetrabromobisphenol-S (TBBPS), are typical EDCs that are frequently detected in environmental and human samples. However, only a few studies have assessed the co-exposure of these chems. in humans. In this study, urine samples were collected from the general population in the city of Wuxi (n = 121) and a county, Taishun (n = 120), eastern China, and analyzed for these EDCs. Parabens, bisphenols, TCS, and benzophenones were frequently detected in urine, whereas TBBPA and its derivatives were not detected. The geometric mean concentrations of parabens, bisphenols, and benzophenones in urine from the Wuxi population were 25.7, 2.45, and 2.34 ng/mL, resp., which were substantially higher than those from the Taishun population (17.2, 1.70, and 2.65 ng/mL). These results suggest an urban-rural difference in urinary EDCs. The exposure risks to these EDCs were estimated based on the measured urinary concentrations and acceptable daily intakes (ADIs). Hazard quotient values for EDCs in humans from both locations were generally less than 1, indicating a low exposure risk of EDCs in these regions. Nonetheless, the health risks caused by co-exposure to such EDCs cannot be ignored. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2SDS of cas: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation and comparison of in vitro intrinsic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout was written by Black, Sherry R.;Nichols, John W.;Fay, Kellie A.;Matten, Sharlene R.;Lynn, Scott G.. And the article was included in Toxicology in 2021.HPLC of Formula: 101-20-2 This article mentions the following:

In vitro and in silico methods that can reduce the need for animal testing are being used with increasing frequency to assess chem. risks to human health and the environment. The rate of hepatic biotransformation is an important species-specific parameter for determining bioaccumulation potential and extrapolating in vitro bioactivity to in vivo effects. One approach to estimating hepatic biotransformation is to employ in vitro systems derived from liver tissue to measure chem. (substrate) depletion over time which can then be translated to a rate of intrinsic clearance (CLint). In the present study, cryopreserved hepatocytes from humans, rats, and rainbow trout were used to measure CLint values for 54 industrial and pesticidal chems. at starting test concentrations of 0.1 and 1 渭M. A data evaluation framework that emphasizes the behavior of Heat-Treated Controls (HTC) was developed to identify datasets suitable for rate reporting. Measured or estimated (“greater than” or “less than”) CLint values were determined for 124 of 226 (55 %) species-chem.-substrate concentration datasets with acceptable anal. chem. A large percentage of tested chems. exhibited low HTC recovery values, indicating a substantial abiotic loss of test chem. over time. An evaluation of KOW values for individual chems. suggested that in vitro test performance declined with increasing chem. hydrophobicity, although differences in testing devices for mammals and fish also likely played a role. The current findings emphasize the value of neg. controls as part of a rigorous approach to data quality assessment for in vitro substrate depletion studies. Changes in current testing protocols can be expected to result in the collection of higher quality data. However, poorly soluble chems. are likely to remain a challenge for CLint determination In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2HPLC of Formula: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trichlorocarban induces developmental and immune toxicity to zebrafish (Danio rerio) by targeting TLR4/MyD88/NF-魏B signaling pathway was written by Xu, Jiaqi;Qian, Qiuhui;Xia, Min;Wang, Xuedong;Wang, Huili. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2021.Recommanded Product: 101-20-2 This article mentions the following:

Trichlorocarban (TCC) is ubiquitously detected in environmental matrixes, while there is a paucity of information regarding its systemic toxicity. In the present study, we observed that TCC exposure led to high embryo mortality, delayed hatching and yolk absorption, as well as increased malformations, such as closure of swim sac and yolk sac edema. Meanwhile, TCC affected the formation and branch of subintestinal veins (SIVs), intersegmental vessels and posterior cardinal veins. Especially, the SIVs were shrunk, and their branches were reduced or even broken along with reduced coverage area. TCC-induced oxidative stress and excessive apoptosis resulted from abnormal expression of the anti/pro-apoptotic genes. Significant reduction in the number and aggregation function of immune cells proved that TCC had prominent immunotoxicity to zebrafish. TCC-targeted TLR4 signaling pathway was demonstrated by abnormal expression of the marker genes (tlr4, MyD88 and nf-魏b) and release of the downstream inflammatory factors (TNF-伪, IL-6, etc.). Inhibition of TLR4/MyD88/NF-魏B pathway by an inhibitor (CA-4948) rescued the decreasing trend of the immune cells induced by TCC. Mol. docking results demonstrated that TCC could stably bind to TLR4 receptor to form hydrogen bonds and hydrophobic interactions with amino acids. Overall, these findings reveal the underlying mol. mechanisms on TCC-induced developmental and immune toxicity to zebrafish. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluating sewer exfiltration in groundwater by pharmaceutical tracers after the 2016 Kumamoto earthquakes, Japan was written by Kobayashi, Jun;Kuroda, Keisuke;Miyamoto, Chinatsu;Uchiyama, Yukiko;Sankoda, Kenshi;Nakajima, Daisuke. And the article was included in Journal of Hazardous Materials in 2021.Formula: C13H9Cl3N2O This article mentions the following:

In Apr. 2016, a series of earthquakes (M 7.3 on the Japan Meteorol. Agency scale) occurred in Kumamoto, Japan causing serious damage to underground sewerage networks. In this study, we evaluated sewer exfiltration in groundwater in the Kumamoto area after the earthquakes by using multiple tracers. We used 14 pharmaceuticals, including carbamazepine and crotamiton, and anthropogenic Gd as tracers, and we measured concentrations of these tracers from Sept. 2016 to Nov. 2017 seasonally. The detection frequency of caffeine, carbamazepine, crotamiton, ibuprofen, and anthropogenic Gd ranged from 29% to 45%, and the concentrations of the pharmaceuticals in the groundwater were lower than those in previous studies. The median of all pharmaceutical concentrations did not decrease, whereas the median of the sum of crotamiton and carbamazepine concentrations, which are quant. sewage markers, decreased with time. The sewer exfiltration rates in Sept. 2016 estimated using carbamazepine, crotamiton, and anthropogenic Gd were 0.59 卤 0.27%, 0.66 卤 0.47%, and 0.11 卤 0.18% of sewage dry weather flow, resp., indicating that the effect of the earthquakes on sewer exfiltration was small, probably because the damaged sewers were quickly repaired. This study demonstrated that a multiple-tracer approach is useful for evaluating sewer exfiltration after major earthquakes. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fate, toxicity and effect of triclocarban on the microbial community in wastewater treatment systems was written by Wang, Hao;Yun, Hui;Li, Minghan;Cui, Hanlin;Ma, Xiaodan;Zhang, Yanqing;Pei, Xuanyuan;Zhang, Liying;Shi, Ke;Li, Zhiling;Liang, Bin;Wang, Aijie;Zhou, Jizhong. And the article was included in Journal of Hazardous Materials in 2022.Computed Properties of C13H9Cl3N2O This article mentions the following:

Triclocarban (TCC), one of the typical antimicrobial agents, is a contaminant of emerging concern commonly found in high concentration in water environments. However, the fate and toxicity of TCC in wastewater treatment systems remain poorly understood. Here, we investigated how TCC impacts COD and inorganic nitrogen transformation in a hydrolytic anaerobic-anoxic/oxic process. In the anaerobic section, the transformation of TCC was dominated by reductive dechlorination and supplemented by two amid bonds hydrolysis. In the anoxic and oxic sections, the hydrolysis of amid bonds dominated. The toxicity was reduced after the treatment (IC₅₀ from 0.09 to 0.54). TCC inhibited NH⁺₄-N removal in the anaerobic section and led to the NO^–₃-N accumulation (2.84-4.13 mg/L) after treatment, with the abundance of N-removal bacteria decreased by 6%. Furthermore, the original ecol. niche was gradually replaced by TCC-resistant/degradative bacteria, formating new microbial modules to resist the TCC stress. Importantly, fourteen genera including Methanosaeta, Longilinea, Dokdonella and Mycobacterium as potential bioindicators warning TCC and its intermediates were proposed. Overall, this study provides new insights into the fate of TCC in biol. wastewater treatment systems and suggests a great importance for TCC control to ensure the health and resilience of ecosystems. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Computed Properties of C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening was written by Song, Yuchen;Zhang, Cui;Lei, Hehua;Qin, Mengyu;Chen, Gui;Wu, Fang;Chen, Chuan;Cao, Zheng;Zhang, Ce;Wu, Mengjing;Chen, Xiaoyu;Zhang, Limin. And the article was included in Science of the Total Environment in 2022.COA of Formula: C13H9Cl3N2O This article mentions the following:

Triclosan (2,4,4-trichloro-2-hydroxydiphenyl ether, TCS) and triclocarban (3,4,4-trichloro-carbanilide, TCC) are two antimicrobial agents commonly used for personal care products. Previous studies primarily focused on resp. harmful effects of TCS and TCC. In terms of their structural similarities and differences, however, the structure-toxicity relationships on health effects of TCS and TCC exposure remain unclear. Herein, global 1H NMR-based metabolomics was employed to screen the changes of metabolic profiling in various biol. matrixes including liver, serum, urine, feces and intestine of mice exposed to TCS and TCC at chronic and acute dosages. Metagenomics was also applied to analyze the gut microbiota modulation by TCS and TCC exposure. Targeted MS-based metabolites quantification, histopathol. examination and biol. assays were subsequently conducted to supply confirmatory information on resp. toxicity of TCS and TCC. We found that oral administration of TCS mainly induced significant liver injuries accompanied with inflammation and dysfunction, hepatic steatosis fatty acids and bile acids metabolism disorders; while TCC exposure caused marked intestine injuries leading to striking disruption of colonic morphol., inflammatory status and intestinal barrier integrity, intestinal bile acids metabolism and microbial community. These comparative results provide novel insights into structure-dependent mechanisms of TCS-induced hepatotoxicity and TCC-triggered enterotoxicity in mice. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2COA of Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016 was written by Uche, Uloma Igara;King, Christopher C.. And the article was included in Archives of Environmental & Occupational Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

This study examined the association between triclocarban and obesity among US adults and compared the pattern of this association across age, gender, and racial/ethnic groups. Study found triclocarban to be associated with obesity (OR: OR:1.123 95% CI: 1.046, 1.205) and this association remained among women (OR:1.14 95% CI: 1.031, 1.261). Study participants aged 60 years and older were more likely to be overweight (OR:1.131 95% CI: 1.022 1.251) and obese (OR:1.192 95% CI: 1.079, 1.317) when compared to other age groups. Likewise, non-Hispanic whites (OR:1.126 95% CI: 1.003, 1.263) and “other race including multi-racial” (OR:1.431 95% CI: 1.219, 1.679) were more likely to be obese when compared to other racial/ethnic groups. In conclusion, triclocarban is associated with obesity among US adults and there is evidence of gender, age, and racial/ethnicity differences in the association In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016 was written by Uche, Uloma Igara;King, Christopher C.. And the article was included in Archives of Environmental & Occupational Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

This study examined the association between triclocarban and obesity among US adults and compared the pattern of this association across age, gender, and racial/ethnic groups. Study found triclocarban to be associated with obesity (OR: OR:1.123 95% CI: 1.046, 1.205) and this association remained among women (OR:1.14 95% CI: 1.031, 1.261). Study participants aged 60 years and older were more likely to be overweight (OR:1.131 95% CI: 1.022 1.251) and obese (OR:1.192 95% CI: 1.079, 1.317) when compared to other age groups. Likewise, non-Hispanic whites (OR:1.126 95% CI: 1.003, 1.263) and “other race including multi-racial” (OR:1.431 95% CI: 1.219, 1.679) were more likely to be obese when compared to other racial/ethnic groups. In conclusion, triclocarban is associated with obesity among US adults and there is evidence of gender, age, and racial/ethnicity differences in the association In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Occurrence of endocrine disrupting chemicals (EDCs) in river water, ground water and agricultural soils of India was written by Saha, S.;Narayanan, N.;Singh, N.;Gupta, S.. And the article was included in International Journal of Environmental Science and Technology in 2022.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Endocrine disrupting chems. are exogenous chems. which alter the functions of endocrine system. There are very few studies of occurrence and distribution of endocrine disrupting chems. in water, soil and their potential human health risks under Indian conditions. In the present work, occurrence of eleven endocrine disrupting chems. namely bisphenol-A, triclosan, triclocarbon, 4-nonylphenol, 4-tert octylphenol, Me paraben, Pr paraben, Bu paraben, benzyl Bu phthalate, di (2-ethylhexyl) phthalate and di-Bu phthalate have been investigated in 20 river water samples, 5 ground water samples and 23 agricultural soil samples collected from 26 sampling points of different agro-climatic zones of India during 2019-2020. Instrument detection and quantification limits of different endocrine disrupting chems. using LC-MS/MS varied from 0.001 to 0.05 and 0.005-0.1 μg/mL, resp. Detection frequencies of bisphenol A, 4-nonylphenol, 4-tert octylphenol and di-Bu phthalate were 100% in river water samples. In ground water samples di-Bu phthalate, benzyl Bu phthalate, di (2-ethylhexyl) phthalate, triclosan, triclocarbon, 4-tert octylphenol, 4-nonylphenol, Pr paraben and Bu paraben and in soils 4-tert octylphenol, 4-nonylphenol, bisphenol-A and di-Bu phthalate were detected in 100% sample. High mean concentrations of di (2-ethylhexyl) phthalate were recorded in river waters (2706.135 μg/L), ground waters (3203.33 μg/L) and agricultural soils (1005.490 ng/g). Other chems. detected in high concentrations were 4-tert octylphenol (180.680-829.93 μg/L), di-Bu phthalate (117.492-182.29 μg/L) and bisphenol-A (13.99-228.03 μg/L). Widespread distribution and high concentrations of these chems. in water and soil is a cause of concern and, therefore, continued monitoring of these chems. in different environmental matrixes is the need of the hour. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pharmaceuticals and Personal Care Products across Different Water Bodies in Taihu Lake Basin, China: Occurrence, Source, and Flux was written by Huang, Jichao;Ding, Jiannan;Jiang, Hang;Wang, Zhenguo;Zheng, Lixing;Song, Xiaojun;Zou, Hua. And the article was included in International Journal of Environmental Research and Public Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Although pharmaceuticals and personal care products (PPCPs) have attracted great attentions, their occurrence characteristics across different water bodies at a basin scale remain poorly understood. To grasp a more comprehensive understanding of PPCP pollution from the perspective of the whole basin, the occurrence, spatial and seasonal variation, source, and flux of thirteen PPCPs across the different environmental compartments of the northern Taihu Lake Basin (TLB) were studied. The results showed that the non-therapeutic pharmaceuticals caffeine (CFI) and n, n-diethyl-m-toluamide (DEET) were the main components across the different environmental compartments. The total concentrations of detected PPCPs ranged from 0.2 to 2437.9 ng/L. Higher concentrations of PPCPs were observed in spring and autumn, which were mainly attributed to seasonal differences in PPCP consumption. Generally, pollution level was higher in industry and agriculture area and in the inner bay and southwest of Taihu Lake. Source apportionment indicated that untreated water was the main source of PPCPs in river waters of the northern TLB. Flux estimation showed that the mean annual flux of PPCPs from northern TLB to Taihu Lake in 2021 was 1.6 t/a, which was higher in comparison with other areas. Overall, the resulting data will be useful to enrich the research of PPCPs in freshwater for environmental investigations. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics