Category: 101-79-1

Reference of 101-79-1,Some common heterocyclic compound, 101-79-1, name is 4-(4-Chlorophenoxy)aniline, molecular formula is C12H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. r4- (4-Chloro-phenoxy)-phenylaminol-acetic acid ethyl ester. Oxo-acetic acid ethyl ester (0.243 g, 2.38 mmol) was added to a solution of 4- (4-chloro- phenoxy)-phenylamine (0.5 g, 2.27 mmol) in DCE (48 mL). The mixture was stirred at rt for 15-20 min, before the addition of Na (OAc) 3BH (0.625 g, 2.95 mmol) and AcOH (0.24 mL). The mixture was stirred at rt for 5 h. More oxo- acetic acid ethyl ester (0.08 g) and AcOH (0.03 mL) were added, and the mixture was stirred at rt overnight. Saturated NaHCO3 (50 mL) and excess CH2CI2 (50 mL) were then added to the reaction mixture. The aqueous layer was extracted with CH2CI2 (3 X 50 mL). The combined organic layers were washed with brine (40 mL) and dried (MgS04), and the solvent was removed. Purification by column chromatography with 20-50percent EtOAc/hexanes afforded 0.4 g (61 percent) of the desired product. MS (electrospray) : mass calculated for Ct4H12CINO3, 305.76 ; m/z found, 306.1 [M+H] +.’H NMR (400 MHz, CDCI3) : 7.25-7. 23 (m, 2H), 6.93-6. 86 (m, 4H), 6.64-6. 62 (m, 2H), 4.28 (dd, J= 14.3, 7.1 Hz, 2H), 3.92 (s, 2H), 1.33 (t, J= 7.1 Hz, 3H).

The synthetic route of 101-79-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2005/44810; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101-79-1, name is 4-(4-Chlorophenoxy)aniline, A new synthetic method of this compound is introduced below., 101-79-1

A solution of 4-tert-butyl-2-aminopyridine (0.177 g, 1.18 mmol, 1 equiv.) in 1.2 mL of anh. CH2Cl2 (1.2 mL) was added to CDI (0.200 g, 1.24 mmol, 1.05 equiv) and the mixture was allowed allowed to stir under argon at room temperature 1 d. To the resulting solution was added 4-(4-chlorophenoxy)aniline (0.259 g, 1.18 mmol, 1 equiv.) in one portion. The resulting mixture was stirred at room temperature for 1 d, then was treated with a 10percent citric acid solution (2 mL) and allowed to stir for 1 h. The resulting organic layer was extracted with EtOAc (3*5 mL). The combined organic layers were dried (MgSO4) and concentrated in vacuo. The resultant residue was treated with CH2Cl2 (10 mL) and a 1N aqueous NaOH solution. This mixture was allowed to stir overnight. The resulting organic layer was extracted with CH2Cl2 (3*5 mL). The combined organic layers were (MgSO4) and concentrated in vacuo. The resultant solids were suspended in diethyl ether (10 mL) and sonicated for 15 minutes. The resulting white solid were dried to give N-(4-tert-butylpyridyl)-N’-(4-(4-chlorophenoxy)phenyl) urea (42 mg, 9percent): mp 198-199¡ã C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER CORPORATION; US2002/165394; (2002); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics