Electric Literature of 1017777-58-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1017777-58-0, name is 2-Chloro-6-fluoro-3-methoxyaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-chloro-6-fluoro-3-methoxy-aniline (0.85 g, 4.84 mmol, 1.0 eq) in DCM (8 mL) at 0C was added BBr3 (6.06 g, 24.2 mmol, 5.0 eq). The mixture was stirred at room temperature under N2 overnight, then poured into ice-water. The pH of the solution was adjusted to pH 6 by addition of sat.NaHC03. The dichloro methane was removed under reduced pressure and the aqueous residue was extracted with EtOAc. The combined organic extracts were washed with brine, dried (Na2SC>4), filtered and evaporated in vacuo to give the title compound as a pale yellow solid (0.74 g, 95 %).LC-MS: m/z 162.0, 164.0 [M+H]1H NMR (400 MHz, DMSO-d6) delta 9.67 (s, 1H), 6.80 (dd, JJ= 8.9, 4.6 Hz, 1H), 5.20 (br s, 2H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-fluoro-3-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David; WO2013/37705; (2013); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics