Category: 102-49-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102-49-8, name is 3,4-Dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3,4-Dichlorobenzylamine

tert-butyl(2-(N-cyclohexylacrylamido)ethyl)(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate (100 mg, 0.205 mmol) and (3,4-dichlorophenyl)methanamine (72 mg, 0.41 mmol) were dissolved in ethanol (1 mL) and heated at 50° C. for 20 hours. The solvent was evaporated in vacuo and the residue dissolved in dichloromethane (1 mL). Trifluoroacetic acid (1 mL, 13 mmol) was added and the mixture stirred for 2 hours, and then concentrated under reduced pressure. The residue was purified by prep-HPLC with (eluting with acetonitrile and 0.2percent aqueous trifluoroacetic acid) to afford the title compound (125 mg, 0.155 mmol, 76percent yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 10.04-9.98 (m, 1H), 9.94-9.84 (m, 1H), 8.81 (s, 2H), 8.43 (s, 1H), 7.88-7.80 (m, 1H), 7.80-7.72 (m, 1H), 7.56-7.46 (m, 1H), 6.70-6.62 (m, 1H), 6.52-6.41 (m, 1H), 4.57-4.48 (m, 2H), 4.27-4.18 (m, 2H), 3.56-3.41 (m, 1H), 3.17-3.03 (m, 5H), 2.98 (d, J=12.0 Hz, 2H), 2.76 (dq, J=14.9, 6.9 Hz, 4H), 1.82-1.74 (m, 2H), 1.71-1.58 (m, 3H), 1.56-1.17 (m, 4H), 1.15-1.03 (m, 1H). MS (ESI+) 563.3 [M+H]+.

According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AbbVie Inc.; Chiang, Gary G.; Pappano, William N.; Sweis, Ramzi F.; Wang, Zhi; (23 pag.)US2016/31838; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To an oven-dried screw-capped reaction tube equipped with a magnetic stirring bar theketone (1 eq), amine (2.8 eq), 4-nitrophenyl azide (2 eq), acetic acid (10 molpercent) and 4 Amolecular sieves (50 mg) were added. The reaction mixture was dissolved in toluene(0.3M) and stirred at 100 °C for 18 hours. The crude reaction mixture was then directlypurified by column chromatography (silica gel) at first with dichloromethane (DCM) aseluent to remove all 4-nitroaniline formed during the reaction followed by using a mixtureof heptane and ethyl acetate as eluent to afford the corresponding 1,2,3-triazoles asyellow oil.

The synthetic route of 102-49-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Karypidou, Konstantina; Ribone, Sergio R.; Quevedo, Mario A.; Persoons, Leentje; Pannecouque, Christophe; Helsen, Christine; Claessens, Frank; Dehaen, Wim; Bioorganic and Medicinal Chemistry Letters; vol. 28; 21; (2018); p. 3472 – 3476;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of tosylate 1 (100 mg, 0.29 mmol) in Acetone or CHCl3 (3 mL) was slowly added amine 2 (0.58 mmol) and ketone 3 (0.87 mmol). Then p-TsOH (25 mg, 0.145 mmol)was addedto the reaction mixture. The resultant mixture was stirred at 60 C for 24 h until the reaction was completed as indicated by TLC. The reaction mixture was concentrated in vacuo, and then extracted with saturated aqueous NaHCO3 and CH2Cl2. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 4 or 5 as syrups.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Dichlorobenzylamine, its application will become more common.

Reference:
Article; Yuan, Wen; Xia, Jianhui; Zhang, Xiaoke; Liang, Peng; Zhang, Jichao; Jiao, Wei; Shao, Huawu; Tetrahedron; vol. 72; 27-28; (2016); p. 3994 – 4000;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H7Cl2N

Intermediate 15 N-(3,4-dichlorobenzyl)-7-methylimidazo[1,2-b]pyridazin-6-amine; To a mixture of 6-chloro-7-methylimidazo[1 ,2-b]pyridazine (0.20 g, 1.19 mmol) and 3,4-dichlorobenzylamine (0.24 ml_, 1.78 mmol) in 1 ,4-dioxane (7 ml_), were added sodium tert-butoxide (0.18 g, 1.91 mmol), (R)-(+)-2,2′- bis(diphenylphosphino)-1 ,1′-binaphthyl (0.06 g, 0.10 mmol) and tris(dibenzylideneacetone)dipalladium(0) (0.04 g, 0.06 mmol) at room temperature. The reaction mixture was heated at 1000C for 1 hour under microwave irradiation. The crude mixture was diluted with ethyl acetate/water and acidified with hydrochloric acid (2N) to pH 3, then extracted with ethyl acetate. The combined organic layers were dried (magnesium sulphate) and concentrated in vacuo. The crude mixture was purified by flash column chromatography (hexane/ethyl acetate 1 :4) followed by precipitation with diethyl ether to give N- (3,4-dichlorobenzyl)-7-methylimidazo[1 ,2-b]pyridazin-6-amine (0.25 g, 48percent yield) 1H NMR (300 MHz, CDCI3): delta 7.51 (1 H, s), 7.41 (2H, bs), 7.36 (1 H, s), 7.32 (1 H, d, J = 8.2 Hz), 7.15 (1H, dd, J = 2.3, 8.2 Hz), 4.47 (2H, d, J = 5.2 Hz), 4.43 (bs, 1 H), 2.14 (S, 3H). LCMS: 307 [M+1]. (MW: 307.2)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 102-49-8, its application will become more common.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); WO2009/60197; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 102-49-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-49-8, name is 3,4-Dichlorobenzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2,2,2-Trichloro-1-(1H-pyrrol-2-yl)ethanone (2) (0.200 g, 0.94 mmol) and benzylamine (0.101 g, 0.11 mL, 0.94 mmol) were dissolved in acetonitrile (15.0 mL). Triethylamine (5 equiv, 0.65 mL) was added to the solution, and the reaction mixture stirred at 60 °C for 24 h. Solvent was removed from the reaction by rotary evaporation. The resulting yellow oil was purified using 5percent MeOH/CH2Cl2 to afford N-benzyl-1H-pyrrole-2-carboxamide (0.123 g, 65percent) as a white solid, mp 128?130 °C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dyson, Lauren; Wright, Anthony D.; Young, Kelly A.; Sakoff, Jennette A.; McCluskey, Adam; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1690 – 1699;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102-49-8, name is 3,4-Dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3,4-Dichlorobenzylamine

General procedure: The acid (9a?h) (1 mmol) and amine (1 mmol) were dissolvedin dimethylformamide (5v) under argon atmosphereand N-ethyl diisopropylamine (3 mmol) was added dropwise to it at 0 °C and HATU (1.3 mmol) was added lot wiseduring a period of 15 min. The reaction medium was slowlyallowed to reach room temperature and stirred for 4 h atroom temperature. The reaction progress was monitored byTLC. After completion of the reaction, the reaction mixturewas poured to ice cold water and stirred at room temperaturefor 30 min and the precipitated solid was filtered,washed with water and dried under vacuum. This crudeproduct was further purified by column chromatographyusing 2?5percent of methanol in chloroform to get the requiredamide.#10;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 102-49-8.

Reference:
Article; Ajeesh Kumar; Bodke, Yadav D.; Lakra, Peter Serjious; Sambasivam, Ganesh; Bhat, Kishore G.; Medicinal Chemistry Research; vol. 26; 4; (2017); p. 714 – 744;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-49-8 as follows. category: chlorides-buliding-blocks

General procedure: EDC hydrochloride (1.2 mmol) and HOBt (1.0 mmol) were added at 0 °C to each parallel vial containing a solution of the appropriate acid 44-53 (1 mmol) in dichloromethane, and either cyclohexylamine or 2,3-dichlorobenzylamine (1.5 mmol) was added at the same temperature. After warming up to room temperature, the vials were placed in the Buechi Syncore reactor. Stirring was maintained at 300 rpm overnight and then morpholinomethylpolystyrene (3 equiv/mol) was added. The solutions were kept at room temperature for 1 h, then polymer bound p-toluenesulfonic acid (3 equiv/mol) was added to each vial, and the reaction mixtures were stirred at room temperature for an additional 24 h. The mixtures were filtered and the solutions were evaporated to dryness to give carboxamides 6-25. Solid products were purified by crystallization from ethanol or aqueous ethanol. Oil products were purified by silica gel column chromatography column (dichloromethane as eluent).

According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Piscitelli, Francesco; Ligresti, Alessia; La Regina, Giuseppe; Gatti, Valerio; Brizzi, Antonella; Pasquini, Serena; Allar, Marco; Carai, Mauro Antonio Maria; Novellino, Ettore; Colombo, Giancarlo; Di Marzo, Vincenzo; Corelli, Federico; Silvestri, Romano; European Journal of Medicinal Chemistry; vol. 46; 11; (2011); p. 5641 – 5653;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102-49-8, name is 3,4-Dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

Example 1: N-(3,4-dichlorobenzvl)-4-methvlpiperazine-l-carboxamideTo a solution of 3,4-dichlorobenzylamine (0.195 g, 1.11 mmol) and diisopropylethylamine(0.193 mL, 1.11 mmol) in 4 mL of THF was added a preformed solution of 4-nitrophenylchloroformate (0.223 g, 1.11 mmol) in 4 mL of THF. The reaction mixture was stirred at RTfor 3.5 h. To this solution was added N-methyl piperazine (0.442 g, 4.42 mmol) and theresulting solution was stirred at RT for 16h. The reaction mixture was concentrated underreduced pressure, diluted with EtOAc (50 mL) and the solution was washed with saturatedaqueous sodium bicarbonate (2 x 50 mL) and brine (50 mL). The solvent was removed underreduced pressure and the residue was subjected to supercritical fluid chromatography (21 mmx 150 mm diol-bonded SiC>2 (6|J,m particle size), isocratic method, 25percent MeOH (containing0.5percent isopropyl amine) in CO2) to afford the title compound as a pale yellow solid (0.245 g,73percent). MS m/z 302.2 (M+H)+; .H NMR (300.1 MHz, DMSO-d6) 52.17 (s, 3H), 2.22-2.26(m, 4H), 3.25-3.31 (m, 4H), 4.20 (d, J=5.8Hz, 2H), 7.12 (t, J=5.8Hz, 1H), 7.23 (dd, .7=8.2,2.0Hz, 1H), 7.47 (d, J=1.8Hz, 1H), 7.56 (d, /=8.2Hz, 1H).

According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2006/14135; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 102-49-8, These common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: 1-(3-amino-1H-1,2,4-triazol-5-yl)-N-(3,4-dichlorobenzyl)piperidine-4-carboxamideTo a suspension of 1-(3-amino-1H-1,2,4-triazol-5-yl)piperidine-4-carboxylic acid hydrochloride (200 mg, 0.62 mmol) in CH2Ch(20 ml), DIPEA (0.64 ml, 3.72 mmol) was added. Then sequentially, 0-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium5 hexafluorophosphate (HATU) (130 mg, 0.34 mmol) and 3,4-dichloro-benzylamine (55 mg, 0.31 mmol) were added.Reaction mixture was stirred at room temperature for 20 h. Precipitatewas filtered, washedwith several times with Et20, dissolved in 4M NaOH (20 ml) and extracted with ethyl acetate(5 x 40 ml). Combinedorganic layers were washed withbrine (2 x 20 ml), dried over MgS04 and strippedto give 85 mg of crude product.10 Crystallization with MeOH I AcOEt I Et20 gave 46 mg of pure product(yield 40 percent) 1H NMR (DMSO-d6, 200 MHz) 8 (ppm): 10.95 (bs, 1 H), 8.37 (t, 1=5.6 Hz, 1H), 7.55 (d, 1=8.6 Hz, 1 H), 7.43 (d, 1=1.5 Hz, 1 H), 7.18 (dd, ]]=8.6 Hz, 12=1.5 Hz, 1 H), 5.57 (bs, 1 H), 4.21 (d, 1=5.6 Hz, 2 H), 3.77 (d, 1=13.1 Hz, 2 H), 2.61-2.52 (m, 2 H), 2.35-2.19 (m, 1 H), 1.72-1.41 (m, 4 H). ESI MS for C1sH18ChN60 calculated 368.09, found 369.51371.5 [M+H]+

The synthetic route of 102-49-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE INSTITUTE FOR DRUG DELIVERY; CORMAN, Michael L.; HUNGERFORD, William M.; GOLEBIOWSKI, Adam; BECKETT, Raymond P.; MAZUR, Marzena; OLEJNICZAK, Sylwia; OLCZAK, Jacek; WO2015/95701; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

102-49-8, name is 3,4-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H7Cl2N

Example 316 ethyl 4-[({[2-({[(3,4-dichlorophenyl)methyl]amino}carbonyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl}oxy)methyl]benzoate A suspension of ethyl 5-{[({4-[(ethyloxy)carbonyl]phenyl}methyl)oxy]methyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate (0.400 g, 0.961 mmol) obtained in Reference Example 158 and 1-(3,4-dichlorophenyl)methanamine (0.287 g, 1.63 mmol) in ethanol (16 mL) was stirred with heating at 80° C. for 15 hrs. The mixture was allowed to cool to room temperature and the precipitated solid was collected by filtration and washed with ethanol to give the title compound as a white powder (475 mg, 91percent). melting point: 253-254° C.

The synthetic route of 102-49-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; Terauchi, Jun; Nara, Hiroshi; Oki, Hideyuki; Sato, Kenjiro; (166 pag.)US2015/329556; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics