Category: 10272-06-7

Adding a certain compound to certain chemical reactions, such as: 10272-06-7, name is 3-Chloro-5-methoxyaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10272-06-7, Recommanded Product: 10272-06-7

General procedure: To a solution of ethyl 4-bromo-1H-indole-2-carboxylate in toluene underargon atmosphere was added Pd2(dba)3 (0.1 eq), DavePhos (0.2 eq), K3PO4 (3 eq, 1Maqueous solution) and aryl amine (3 eq), and then the mixture was reacted at 80 Cuntil the starting material disappeared. The mixture was cooled to room temperatureand concentrated. Ethyl acetate was added to dissolve the residue and the mixture waswashed with saturated brine and water, dried over anhydrous Na2SO4, andconcentrated in vacuo. The crude product was purified by column chromatography toafford the target compound. Compounds 8a-8f, 8i-8l, 8a-1, 8a-6 ~ 8a-11, 8a-14 wereprepared with method 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-5-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cui, Guonan; Lai, Fangfang; Wang, Xiaoyu; Chen, Xiaoguang; Xu, Bailing; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 10272-06-7, These common heterocyclic compound, 10272-06-7, name is 3-Chloro-5-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(5.0 g, 31.72 mmol) was added to a stirred solution of (2) (3.11 g,31.72 mmol) in Et20 (60 mL) at a The reaction mixture was stirred at rt for 4 hr. The resulting mixture was evaporated in vacuo to give the crude product. This was triturated with Et20 and dried in vacuo to give 5.0 g (61.7% yield) of pure product as an off-whitesolid, which was used without further purification in the next step. LCMS m/z 256 [M + H- 11, 25 [M + H + 11, 264 [M + H + 31; (99.4% purity). ?H NMR (400 MHz, DMSO-d6) oe12.89 (br s, 1H), 10.43 (s, 1H), 7.36 (dd, J = 2.0 Hz, J = 1.6 Hz, 1H), 7.16 (dd, J = 2.0 Hz, J = 2.0 Hz, 1H), 6.76 (dd, J = 2.4 Hz, J = 2.0 Hz, 1H), 6.44 (d, J = 12 Hz, 1H), 6.31 (d, J = 12 Hz, 1H), 3.75 (s, 3H).

The synthetic route of 10272-06-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FLATLEY DISCOVERY LAB, LLC; ZAWISTOSKI, Michael, P.; DESHPANDE, Asmita; COLE, Bridget, M.; (149 pag.)WO2017/117239; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10272-06-7, name is 3-Chloro-5-methoxyaniline, A new synthetic method of this compound is introduced below., Safety of 3-Chloro-5-methoxyaniline

To a solution of compound obtained from Step c (0.1 g, 0.3003 mmoles) in 7V,7V- dimethylformamide (1 ml) were added 1 -hydroxy benzotriazole (0.04 g, 0.3003 mmoles), N-ethyldiisopropyl amine (0.116 g, 0.9009 mmoles) and 3-chloro-5-methoxyaniline (0.047 g, 0.3003 mmoles) at room temperature. The reaction mixture was allowed to stir at room temperature for about 5 minutes and then l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.086 g, 0.4505 mmoles) was added to it. The reaction mixture was again stirred at room temperature for about 12 hours. After completion, the solvent was evaporated under vacuum, diluted with water and extracted with ethyl acetate. The resulting organic layer was washed with water, dried over anhydrous sodium sulphate, filtered and evaporated under vacuum to afford an oily residue which was purified through flash column chromatography eluting with ethyl acetate :dichloromethane (3:7) to afford the title compound as white solid. Yield: 0.07g.1H NMR (400 MHz, DMSO-i? delta: 9.48 (s, 1H), 7.82 – 7.88 (m, 2H), 7.37 – 7.44 (m, 2H), 7.28 – 7.34 (m, 2H), 7.18 – 7.24 (m, 1H), 7.15 (d, J= 13.64 Hz, 1H), 7.10 (d, J= 8.08 Hz, 2H), 4.91 (s, 2H), 3.82 (s, 3H), 3.07 (s, 3H), 2.17 (s, 3H), 2.15 (s, 3H ).Mass spectrum (m/z, +ve ion mode): 472 [M++l], 474 [M++l+2].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; VERMA, Ashwani Kumar; MALHOTRA, Sanjay; GHORPADE, Satish Madhav; DAWANGE, Mahesh Balasaheb; RAY, Abhijit; GUPTA, Suman; SRIVASTAVA, Punit; DASTIDAR, Sunanda Ghosh; WO2012/14127; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics