Category: 104-52-9

Adding a certain compound to certain chemical reactions, such as: 104-52-9, name is 3-Phenylpropyl Chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104-52-9, COA of Formula: C9H11Cl

Preparation 149 1-[4-(3-chloropropyl)phenyl]ethanone Aluminium chloride (15.0 g, 0.11 moles) and acetyl chloride (16.0 g, 0.20 moles) were dissolved in dichloromethane (50 ml) at room temperature. This mixture was then added dropwise to a solution 1-chloro-3-phenylpropane (15.5 g, 0.10 moles) in dichloromethane (25 ml) at room temperature over 15 minutes. The mixture was stirred for 1 hr and then poured cautiously onto ice. The aqueous layer was extracted with dichloromethane (450 ml). The organics were washed with water and brine, and then dried (MgSO4) and concentrated in-vacuo to give the title compound (19.2 g, 98%) as an oil. 1H-NMR (300 MHz, CDCl3): 2.10 (quintet, 2H), 2.60 (s, 3H), 2.85 (t, 2H), 3.55 (t, 2H), 7.30 (d, 2H), 7.90 (d, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenylpropyl Chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Banks, Bernard Joseph; Critcher, Douglas James; Fenwick, Ashley Edward; Gethin, David Morris; Gibson, Stephen Paul; US2003/207876; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-52-9, name is 3-Phenylpropyl Chloride, A new synthetic method of this compound is introduced below., Safety of 3-Phenylpropyl Chloride

General procedure: Compounds D1-D22 were prepared following the previouslyreported method [37]. To a solution of 3-amino-5-mercapto-1,2,4-triazole (1.0 g, 8.61 mmol) in acetone (30 mL) were added sodiumcarbonate (1.37 g, 12.92 mmol), sodium iodide (129.06 mg,0.861 mmol) and alkyl halide (9.47 mmol). The reaction mixturewas stirred at 60 C for 3e6 h before cooling to room temperature.Na2CO3 and NaI were removed via filtration. The residue was concentrated under vacuum and then dissolved in EtOAc. Theorganic layer was washed with water (2 x 10 mL) and brine(2 x 20 mL) and then dried over anhydrous MgSO4. After removal ofthe solvent, the resulting residue was subjected to column chromatography,giving the corresponding products D1-D22.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Shuai; Li, Zhong-Rui; Suo, Feng-Zhi; Yuan, Xiao-Han; Yu, Bin; Liu, Hong-Min; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 388 – 401;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-52-9, name is 3-Phenylpropyl Chloride, A new synthetic method of this compound is introduced below., Formula: C9H11Cl

General procedure: B1eB22, B40 or B48 (1.0 mmol, 1.0equiv) were dissolved in5mLN,N-dimethylformamide (DMF), and sodium azide was addedto the above solution. The reaction system was stirred at roomtemperature or 70 C for 24 h. Then water (30 mL) was added,extracted with ethyl acetate (3 10 mL). The organic phase wascombined, dried over anhydrous Na2SO4, filtered, and concentratedto yield the crude azide substituents N1eN22, N40 and N48, whichwere used for the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jing, Lanlan; Wu, Gaochan; Hao, Xia; Olotu, Fisayo A.; Kang, Dongwei; Chen, Chin Ho; Lee, Kuo-Hsiung; Soliman, Mahmoud E.S.; Liu, Xinyong; Song, Yuning; Zhan, Peng; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 104-52-9, name is 3-Phenylpropyl Chloride, molecular formula is C9H11Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

General procedure: To a solution of 4-phenylbutyl benzoate 1a (127 mg, 0.5 mmol) and N-hydroxyphthalimide (8.16 mg, 0.05 mmol) in CH3CN (1.7 mL) was added cerium(IV) ammonium nitrate (548 mg, 1.0 mmol) at 0 C. The reaction mixture was immediately warmed to room temperature and stirred for 2 h. The mixture was then filtered through a short column of alumina (hexane-EtOAc 1:1), and the filtrate was concentrated. The residue was purified with flash column chromatography (silica gel, hexane-EtOAc 70:1 to 50:1) to provide 4-benzoyloxy-1-phenylbutyl nitrate 2a in 81% yield (128 mg). 1.0 mmol) at 0 C. The reaction mixture was immediately warmed to room temperature and stirred for 2 h. The mixture was then filtered through a short column of alumina (hexane-EtOAc 1:1), and the filtrate was concentrated. The residue was purified with flash column chromatography (silica gel, hexane-EtOAc 70:1 to 50:1) to provide 4-benzoyloxy-1-phenylbutyl nitrate 2a in 81% yield (128 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 104-52-9, its application will become more common.

Reference:
Article; Kamijo, Shin; Amaoka, Yuuki; Inoue, Masayuki; Tetrahedron Letters; vol. 52; 36; (2011); p. 4654 – 4657;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 104-52-9,Some common heterocyclic compound, 104-52-9, name is 3-Phenylpropyl Chloride, molecular formula is C9H11Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of compound 6 (0.06mmol) in 2 ml DMF was added potassium carbonate (0.18 mmol). The mixture was heated to 90 C and l-(2- chloroethyl)piperidine hydrochloride (0.066 mmol) was added. The reaction mixture was then stirred at 90 C for two hours. After the reaction was completed, the mixture was poured into 50 ml water and then extracted with dichloromethane (50 ml x 3). The organic layer was dried with anhydrous Na2S04 and evaporated to dryness under reduced pressure to give the crude product, which was further purified by flash silica gel column chromatography (methanol : dichloromethane = 1:12) to give a light yellow paste (yield 63%).

The synthetic route of 104-52-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED; LI, Chenglong; MAO, Liguang; (0 pag.)WO2019/165158; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 104-52-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104-52-9, name is 3-Phenylpropyl Chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 2 Preparation of N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride. A reaction mixture consisting of 1000 g. of 3-chloropropylbenzene, 1500 g. of N-bromosuccinimide, 5 g. of benzoyl peroxide and 6 l. of carbon tetrachloride were placed in a 12 l. 3-neck, round-bottom flask equipped with stirrer and condenser. The reaction mixture was stirred and heated until an exothermic reaction began. The heat source was then removed, and the refluxing of reaction mixture controlled by external cooling. After the reaction had been completed as noted by the disappearance of the N-bromosuccinimide, the reaction mixture was cooled and crystalline succinimide collected by filtration. The succinimide filter cake was washed with carbon tetrachloride. The combined filtrate and wash was concentrated in vacuo. The residue comprising 3-chloro-1-bromopropylbenzene obtained in the above reaction was shown by a NMR to be the desired material and was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenylpropyl Chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eli Lilly and Company; US4018895; (1977); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 104-52-9, name is 3-Phenylpropyl Chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104-52-9, name: 3-Phenylpropyl Chloride

15.5 g (0.10 mol) of 3-phenylchloropropane, 4.1 g (0.05 mol) of ethylamine hydrochloride, 0.2 g of tetrabutylammonium bromide and 50 ml of a sodium hydroxide solution (35% to 40%) were placed in a 250 ml flask.Stirring heated to 85-90 C, insulation reaction, TLC tracking.After completion of the reaction, the aqueous layer was extracted three times with ethyl acetate, and the organic layers were combined.Add anhydrous sodium sulfate drying.The filtrate was concentrated under reduced pressure to give 12.4 g of a brownish yellow liquid.Yield: 88%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenylpropyl Chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hebei Kaisheng Pharmaceutical Technology co., LTD; ZHAO, KAI; HOU, JIANPING; ZHAO, YAFENG; YUAN, HONGZHONG; ZHAO, XIAOXIAN; JIAN, YONGXUE; (5 pag.)CN103508898; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common heterocyclic compound, 104-52-9, name is 3-Phenylpropyl Chloride, molecular formula is C9H11Cl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 104-52-9.

To a suspended solution of AlCl3 (8.69 g, 65.2 mmol) and 3-chloropropionylchloride(9.97 g, 64.5 mmol) in dichloromethane (70 mL) was added 3-phenylpropylchloride(7.91 g, 62.8 mmol). The mixture was stirred at room temperature for 4 h and thenquenched by saturated NaHCO3 aq (100 mL). The mixture was extracted with diethylether (100 x 3 mL). The collected organic layer was washed with water (100 x 2 mL)and saturated NaCl aq (100 mL) and then dried (MgSO4). The solvent was evaporatedand the residue was washed with hexane to give the product as white solid (9.73 g,63%).

The synthetic route of 3-Phenylpropyl Chloride has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nishimoto, Yoshihiro; Yazawa, Satoshi; Kiyokawa, Kensuke; Kajiki, Takahito; Tsukahara, Yasunori; Yamauchi, Tomohisa; Wada, Yuji; Baba, Akio; Yasuda, Makoto; Chemistry Letters; vol. 46; 8; (2017); p. 1116 – 1118;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics