Category: 104-77-8

Reference of 104-77-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 46 3-[1-(3-Diethylaminopropyl)-4-piperidyl]-1,2-benzisoxazole difumarate A suspension of 4.0 g of 3-(4-piperidyl)-1,2-benzisoxazole, 3.2 g of 3-diethylaminopropyl chloride, 3.0 g of potassium iodide and 5.0 g of sodium bicarbonate in 100 ml of butanol was heated under reflux for 2 hrs, cooled to room temperature and filtered. The filitrate was washed with water and extracted with ether (3 times). The ether extracts were dried over anhydrous sodium sulfate, filtered and evaporated to give an oil. The oil was dissolved in 10 ml of acetonitrile and 4.2 g of fumaric acid was added. The mixture was stirred for 2 hrs, filtered and the filter cake was recrystallized three times from ethanol-ether to give 2.8 g (26%) of product, mp 174-176. ANALYSIS: Calculated for C19 H29 N3 O2C4 H4 O4: 59.22%C; 6.81%H; 7.67%N; Found: 59.26%C; 7.01%H; 7.33%N.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-N,N-diethylpropan-1-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoechst-Roussel Pharmaceuticals; US4355037; (1982); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 104-77-8,Some common heterocyclic compound, 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine, molecular formula is C7H16ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE IV Bis[3-(diethylamino)propyl]6-oxo-6H-dibenzo[b,d] pyran-3,8-dicarboxylate dihydrochloride A mixture of 11.0 g (0.04 mole) of 6-oxo-6H-dibenzo [b,d]pyran-3,8-dicarboxylic acid, 18.0 g (0.12 mole) of gamma-diethylaminopropyl chloride and 400 ml of isopropyl alcohol are stirred and heated to its reflux temperature. A catalytic amount of benzyltrimethylammonium chloride. 0.3 ml of a 60% aqueous solution, is added and the reaction mixture heated to reflux for an additional 24 hours. On cooling, the reaction mixture is filtered, and the residue washed with isopropyl alcohol. This product is dissolved in boiling ethanol, treated with charcoal, filtered and cooled to room temperature. After standing for 1 hour, the gelatinous precipitate which appears is filtered and the filtrate cooled to -20C. The product which forms is filtered, washed with ethanol and again recrystallized from ethanol to yield the desired bis[3-(diethylamino)propyl] 6-oxo-6H-dibenzo[b,d]pyran-3,8-dicarboxylate dihydrochloride as a tan-colored solid, soluble in water and having a m.p. of 250-1C. (dec.) (placed in m.p. bath previously heated at 240 C.), lambdamax 294, and E1cm 1% 464.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-N,N-diethylpropan-1-amine, its application will become more common.

Reference:
Patent; Richardson-Merrell Inc.; US3933893; (1976); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine, molecular formula is C7H16ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 104-77-8

Preparation 88 4-(Diethylamino)-1-(4-fluorophenyl)-1-butanone A suspension of 73.1 g (0.489 mol) 3-(diethylamino)-propyl chloride and 11.87 g (0.489 mol) of magnesium in 300 mL of tetrahydrofuran is initiated with 0.25 mL of 3M ethylmagnesium bromide in diethyl ether and is refluxed overnight. After this time, the reaction is allowed to cool to 40 C. and is treated with 29.6 g (0.245 mol) of 4-fluorobenzonitrile. The initial exotherm is followed by applied heat and the reaction is refluxed for 3 hr. After this time, the reaction is allowd to cool to room temperature and is quenched with 250 mL of water. This mixture is extracted with 2*250 mL of methylene chloride. The combined organic layers are acidifed to pH=1 with 2N aq. hydrochloric acid and the resulting layers separated. The aqueous extract is washed with 100 mL of methylene chloride and is made basic with 4N of sodium hydroxide. The aqueous mixture is extracted with 3*300 mL of methylene chloride. The combined organic layers are dried over sodium sulfate, filtered and the solvent distilled in vacuo to provide crude title compound. This liquid is distilled under vacuum to provide the title compound. NMR (CDCl3): delta=1.04(t,6), 1.92(m,2), 2.52(m,6), 3.20(t,2), 7.14(t,2) and 8.02 (m,2)ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 104-77-8, its application will become more common.

Reference:
Patent; Schering A.G.; US4851526; (1989); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H16ClN

EXAMPLE 17 Methyl 2-(3-diethylamino-propyl)-5-(3,5-dichlorophenylamino)-2H-1,2,3-triazole-4-carboxylate hydrochloride A mixture consisting of 5.8 gm (0.02 mol) of methyl 1-(3,5-dichlorophenyl)-5-amino-1H-1,2,3-triazole-4-carboxylate, 80 ml of absolute dimethylformamide, 0.8 gm of sodium hydride dispersion and 3.0 gm (0.02 mol) of 1-chloro-3-diethylamino-propane was reacted and worked up as in Example 15. 0.9 gm (9.2% of theory) of the desired compound was obtained; melting point 158 C.

According to the analysis of related databases, 104-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim KG; US4505912; (1985); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 104-77-8, A common heterocyclic compound, 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine, molecular formula is C7H16ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 29 (346) Synthesis of N-(Toluene4-sulfonyl)-L-prolyl-4-[3-(N,N-diethylamino)propoxy]-L-phenylalanine Methyl Ester The methyl ester was prepared via O-alkylation of N-(toluene-4-sulfonyl)-L-prolyl-L-tyrosine methyl ester with 3-diethylaminopropyl chloride in refluxing 2-butanone in the presence of potassium carbonate and sodium iodide. NMR data was as follows: 1H NMR (DMSO-d6, 400 Mhz): delta=1.0 (6H, bs); 1.4-1.6 (4H, m); 1.85 (2H, m); 2.18 (3H, s); 2.5 (2H, bs); 2.5-2.8 (4H, bs); 2.9 (2H, m); 3.1 (1H, dd, J=8, 10, 8 Hz); 3.35 (1H, dd, J=8, 4, 8 Hz); 3.6 (3H, s); 3.94 (2H, t, J=6, 6 Hz); 4.1 (1H, m); 4.48 (1H, dd, J=8, 6, 8 Hz); 6.8 (2H, d, J=10 Hz); 7.1 (2H, d, J=10 Hz); 7.4 (2H, d, J=10 Hz); 7.7 (2H, d, J=10 Hz); 8.2 (1H, d, J=10 Hz). MS: +ESI, m/z 560.5 ([MH]+, 100%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Athena Neurosciences, Inc.; American Home Products Corp.; US6492421; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104-77-8, name is 3-Chloro-N,N-diethylpropan-1-amine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 104-77-8

a Phenylmethyl 1-[3-(diethylamino)propyl]-1H-indole-3-acetate At a temperature of about +50 C., 6.2 g (44.9 mMol) of potassium carbonate were added to a solution of 4.0 g (15.1 mMol) of phenylmethyl 1H-indole-3-acetate in 40 ml of dimethylformamide and then at the same temperature a solution of 3.0 g (20.0 mMol) of 3-(diethylamino)propylchloride in 5 ml of dimethylformamid were added dropwise. The mixture was stirred for a further hour at 50 C. and overnight at ambient temperature, heated up to 100 C. again and once more 1.0 g of 3-(diethylamino)propylchloride were added. After stirring for 5 hours at ambient temperature, the mixture was stirred into 300 ml of ice water and extracted exhaustively with diisopropylether. The combined organic extracts were washed with saturated saline solution, dried over magnesium sulphate, clarified with activated charcoal and evaporated down under reduced pressure. A colourless oil was obtained in a yield of 5.37 g (94% of theory) and was used in the following step without further purification. MS: M+ =378

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 104-77-8.

Reference:
Patent; Karl Thomae GmbH; US6114390; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics