Category: 10541-69-2

Some common heterocyclic compound, 10541-69-2, name is (2,5-Dichlorophenyl)methanamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7Cl2N

The title compound was obtained in analogy to example 1, using 2, 5-dichlorobenzylamine as R4-CH2-NH2, 2,2,3,3,3-pentafluoro-propylamine as R1R2NH and 2-(bromomethyl)-tetrahydro-2H-pyran as R3-(CH2)m-Br, MS (ISP): 500 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10541-69-2, its application will become more common.

Reference:
Patent; Mayweg, Alexander; Narquizian, Robert; Pflieger, Philippe; Roever, Stephan; US2005/250769; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10541-69-2, name is (2,5-Dichlorophenyl)methanamine, A new synthetic method of this compound is introduced below., Quality Control of (2,5-Dichlorophenyl)methanamine

In a 20 mL scintillation vial, 4-amino-5-cyano-6-ethoxy-pyrindine-2-carboxylic acid (19 mg, 0.09 mmol) was dissolved in DMA (0.7 mL). Then TBTU (30 mg, 0.09 mmol) dissolved in DMA (0.7 mL) was added, followed by the addition of 2,5-dichlorobenzylamine (18 mg, 0.11 mmol, 1.2 eq.) in DMA (0.6 mL). Then TEA (9.37 mg, 0.09 mmol) dissolved in DMA (0.7 mL) was added. The mixture was shaken at room temperature for 24 hours. The crude mixture was purified using reverse phase HPLC (TFA). 1H NMR (500 MHz, DMSO-D6/D2O) ? ppm 1.24 (t, 3H) 4.03-4.86 (m, 4H) 5.88-7.87 (m, 4H). MS (ESI) positive ion 365 (M+H)+; negative ion 363(M?H)?.

The synthetic route of 10541-69-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Liu, Gang; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Liu, Mei; US2006/173050; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics