Category: 10543-42-7

Qi, Gang published the artcileSynthesis of coumarin-propanedioic acid dimethyl esters, Synthetic Route of 10543-42-7, the publication is Hecheng Huaxue (2007), 15(4), 466-467, 470, database is CAplus.

Three new coumarin-propanedioic acid di-Me esters were designed and synthesized by matching principle from coumarin and propanedioic acid di-Me ester. The structures were identified by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Ying published the artcileSynthesis and Bioactivity of Coumarin-6-sulfonylureas, Category: chlorides-buliding-blocks, the publication is Zhongguo Yaoke Daxue Xuebao (2002), 33(2), 93-97, database is CAplus.

Twenty-one coumarin-6-sulfonylureas {N-[4-R¹-7-R²-benzopyran-2(2H)-one-6-sulfonyl]-N’-R³-urea; R¹ and/or R² = H or methyl; R³ = cyclohexyl, allyl, Pr, heptyl, iso-Pr, Bu, or isobutyl} were synthesized to search for new antidiabetic drugs. Sulfonylurea functional groups were introduced into the structure of coumarin, and the hypoglycemic activity of the target compounds was measured. Their structures were identified by IR, ¹H NMR, and MS spectra. The pharmacol. study showed that compounds SU-1 (R¹ = R² = H, R³ = cyclohexyl), SU-8 (R¹ = H, R² = Me, R³ = cyclohexyl), SU-11 (R¹ = H, R² = Me, R³ = butyl), SU-12 (R¹ = H, R² = Me, R³ = heptyl), and SU-13 (R¹ = H, R² = Me, R³ = isopropyl) exhibited evident hypoglycemic activities (P <0.01) at the dose of 50 mg kg^-1.

Zhongguo Yaoke Daxue Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sun, Bin published the artcilePhotocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light, Name: Coumarin-6-sulfonyl chloride, the publication is Organic Chemistry Frontiers (2022), 9(14), 3669-3676, database is CAplus.

Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up.

Organic Chemistry Frontiers published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H21NO3, Name: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ying-Hong published the artcileNovel 12N-substituted matrinanes as potential anti-coxsackievirus agents, COA of Formula: C9H5ClO4S, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(4), 829-833, database is CAplus and MEDLINE.

A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound I as the lead. SAR anal. indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound II exhibited the highest potency against all CVB serotypes as well as CVA16 with IC₅₀ values ranging from 2.02 μM to 7.41 μM, indicating a broad-spectrum anti-coxsackieviruse effect. Furthermore, compound II demonstrated a good safety profile in vivo. Thus, we consider 12N-substituted matrinanes to be a promising family of anti-coxsackievirus agents, and compound II to be a promising drug candidate in the treatment of various diseases related to coxsackievirus infection.

Bioorganic & Medicinal Chemistry Letters published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akusoba, E. U. published the artcile6-Coumarinsulfonyl chloride (6CSCL): a fluorescent label for protein molecules, SDS of cas: 10543-42-7, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1985), 320(2), 182-3, database is CAplus.

Albumin and γ-globulin were labeled with 6CSCL, purified by gel chromatog. on Sephadex G 25, and the fluorescence and other properties of the labeled proteins were studied. The fluorescence intensity of labeled albumin decreased slightly with increasing temperature and increased sharply with increasing pH. An increase in dielec. constants of solvents was accompanied by a bathochromic shift in fluorescence maximum for labeled γ-globulin. Freeze-dried conjugate lost no fluorescence intensity after refrigeration for 2 wk. 6CSCL resembles dansyl chloride in its reactions and is a promising cheap and stable label for proteins and amino acids.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarinsulfonamides, COA of Formula: C9H5ClO4S, the publication is Mansoura Science Bulletin, A: Chemistry (1997), 24(1), 161-170, database is CAplus.

Coumarin-6-sulfonyl chloride was amidated with different secondary amines to give coumarin-6-sulfonamides. The latter with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides. Hydrazones were obtained by condensation of the latter with aldehydes. Some reactions of the hydrazones or hydrazides were examined

Mansoura Science Bulletin, A: Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarin sulfonamides, Safety of Coumarin-6-sulfonyl chloride, the publication is Afinidad (1998), 55(473), 67-71, database is CAplus.

Coumarin-6-sulfonyl chloride was animated with different secondary amines to give the sulfonamides. Treatment of these with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides which were converted to hydrazones by reaction with various aldehydes. The hydrazones were cyclized using acetic anhydride to yield oxadiazolines. Reaction of the hydrazides with 4-toluoyl chloride afforded the corresponding N-toluoyl derivatives which cyclized with POCl₃ to the corresponding 1,3,4-oxadiazole derivatives Thiosemicarbazide derivatives were obtained by treatment of the hydrazides with PhNCS. Cyclization of the thiosemicarbazides using POCl₃ afforded the corresponding 1,3,4-thiadiazoles.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Safety of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Aleem, Abd El-Aleem Hassan published the artcileReactions with coumarin-3,6-disulfonyl chloride, Application of Coumarin-6-sulfonyl chloride, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1995), 47(1), 49-54, database is CAplus.

The reaction between coumarin-3,6-disulfonyl chloride (I) and amino compounds is investigated. The acid chloride reacts with aliphatic amines such as Et amine, ethanolamine, ethylenediamine or benzylamine to give the corresponding coumarin-6-sulfonamide derivatives While its reaction with secondary amines, aromatic amines or acid hydrazide gives the corresponding coumarin-3,6-disulfonamides. The reaction with hydrazine hydrate gives coumarin-6-sulfonylhydrazide or coumarin-3,6-disulfonylhydrazide, depends on the reaction conditions.

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Long-Di published the artcileRoom temperature phosphorescence properties of 27 coumarin derivatives on filter paper, Quality Control of 10543-42-7, the publication is Analytica Chimica Acta (1994), 296(1), 99-105, database is CAplus.

Some coumarin derivatives were used as fluorescence labeling agent. The room temperature phosphorescence (RTP) properties of 27 kinds of coumarin derivatives on filter paper were studied. Most of them can give more intensive RTP signals when using 1.0 mol L^-1 lead acetate as a heavy-atom perturber and there is an obvious relation between the RTP characteristics and the substituting group in some of the derivatives The fact that many of the coumarin derivatives can give RTP emission means that they can be expected to serve as RTP labeling agent.

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Quality Control of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Longdi published the artcileRoom temperature phosphorescence properties of 6-coumarinsulfonyl chloride, HPLC of Formula: 10543-42-7, the publication is Fenxi Huaxue (1992), 20(11), 1257-60, database is CAplus.

6-Coumarinsulfonyl chloride (C₆SCl) was used as the fluorescence and low-temperature phosphorescence labeling reagent for amino acids. In this paper, the room-temperature phosphorescence (RPT) of C₆SCl on the several solid substrates, such as filter paper, polyamide films, microcrystalline cellulose, cellulose nitrate, and silica gel for chromatog. etc. was induced successfully by selection of the heavy atom perturbers and exptl. conditions. The RTP emission of C₆SCl has high selectivity, only divalent lead salts are efficient perturber among the examined fifteen compounds and the Pb(OAc)₂ induced the most strong RTP signal. Using 1.0 mol/L Pb(OAc)₂ as the perturber and filter paper as the solid substrate, more intensive RTP signal with high signal to blank ratio was obtained. The RTP signal intensity (λ_x/λ_m = 320/496 nm) as a function of the amount of C₆SCl has a good linear relationship in 0.2 μL sample solution containing 4 to 200 pmol. These results mean that C₆SCl, a new developing luminescence-labeling compound, can be expected to serve as not only a fluorescence labeling reagent, but also a RTP one.

Fenxi Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics