Category: 10543-42-7

Al-Kindy, S. M. Z. published the artcileCoumarin-6-sulfonyl chloride: a novel label in fluorometry and phosphorimetry. Part 1. Synthesis and luminescence properties, HPLC of Formula: 10543-42-7, the publication is Analytica Chimica Acta (1989), 227(1), 145-53, database is CAplus.

Coumarin-6-sulfonyl chloride was synthesized from coumarin in a single step and characterized. It was used to label amines, amino acids and phenols in mild conditions. The products of such reactions show intense fluorescence in alk. solutions as a result of a photolytic ring-opening reaction. The derivatives are also phosphorescent a 77 K without ring opening.

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shalaby, A. M. published the artcileSynthesis of some coumarin-6-sulfono-N-amino acids and evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Bulletin of the National Research Centre (Egypt) (1994), 19(2), 97-106, database is CAplus.

The reaction of 6-coumarinsulfonyl chloride with amino acid esters gave N-[(coumarinyl)sulfonyl]glycine derivatives that were converted to the corresponding N-[(coumarinyl)sulfonyl]glycine hydrazides I (R = alkyl, benzyl, etc.). The antimicrobial activity of N-[(coumarinyl)sulfonyl]glycine hydrazide s and preparation of N-[(coumarinyl)sulfonyl]dipeptides was reported.

Bulletin of the National Research Centre (Egypt) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C16H12O, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd-El-Hafez, O. M. published the artcileSynthesis of some new coumarin derivatives with evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Egyptian Journal of Pharmaceutical Sciences (1994), 35(1-6), 113-26, database is CAplus.

6-Aminocoumarin (I) was condensed with some aromatic aldehydes to give the Schiff’s bases II (R = N:CHR², R¹ = H, R² = C₆H₄OMe-4, C₆H₄Cl-2, C₆H₄Cl-4, C₆H₄NO₂-4, C₆H₄NMe₂, 2-thienyl, X = O). I was also reacted with some halo-compounds to give coumarin-6-amino derivatives II (R = NHR³, R¹ = H, R³ = COCH₂Cl, CH₂CHO, COPh, X = O). 6-Nitrocoumarin-3-sulfonyl chloride II (R = NO₂, R¹ = SO₂R⁴, R⁴ = Cl, X = O) and thiocoumarin-6-sulfonyl chloride II (R = SO₂R⁴, R⁴ = Cl, R¹ = H, X = S) were reacted with some amines to give 6-nitrocoumarin-3-sulfonamide derivatives II (R = NO₂, R¹ = SO₂R⁴, R⁴ = NHNH₂, NMe₂, pyrrolidino, 2-pyridinyl, morpholino, etc., X = O) and thiocoumarin-6-sulfonamide derivatives II (R = SO₂R⁴, R¹ = H, R⁴ = piperidino, pyrrolidino, morpholino), resp. On the other hand, thiocoumarin II (R = R¹ = H, X = S) was reacted with primary amines to give benzopyran-2-imino derivatives II (X = NR⁵, R⁵ = NH₂, Me, NHPh, CH₂Ph, 2-pyridinyl, Ph). The antimicrobial activity of the prepared compounds was also investigated.

Egyptian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ruzi, Rehanguli published the artcileDeoxygenative Arylation of Carboxylic Acids by Aryl Migration, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Chemistry – A European Journal (2019), 25(55), 12724-12729, database is CAplus and MEDLINE.

An unprecedented deoxygenative arylation of aromatic carboxylic acids was achieved, allowing the construction of an enhanced library of unsym. diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chem. allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol was independent of substrate redox-potential, electronic, and substituent effects. It afforded a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Chemistry – A European Journal published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Category: chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C3H6O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yu. published the artcileSynthesis and molecular recognition study of 6-Cs-β-CD, HPLC of Formula: 10543-42-7, the publication is Guangpuxue Yu Guangpu Fenxi (1998), 18(4), 464-467, database is CAplus.

The reagents 6-coumarinsulfonyl-β-cyclodextrin (6-Cs-β-CD) with mol. recognition function were synthesized and identified. Both basic condition and enough illumination were necessary for obtaining stable and strong fluorescence. By using 6-Cs-β-CD as the host, cyclohexanol, cyclohexene, cyclohexane, or bromocyclohexane as the guest, the recognition properties were studied. The affinity of 6-Cs-β-CD and the guest is distinct with different hydrophobicity of the guest.

Guangpuxue Yu Guangpu Fenxi published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C28H41N2P, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shizhong published the artcileA newly developed luminescent label – synthesis and properties of 6-coumarinsulfonyl chloride, Related Products of chlorides-buliding-blocks, the publication is Fenxi Huaxue (1992), 20(2), 202-4, database is CAplus.

The title compound (I) was prepared by reaction if coumarin with ClSO₃H. Effects of pH, lighting and surfactant on the fluorescence properties of its aqueous solution, and the reactiveness to amino acids etc. are studied. The results show that both basic condition and enough lighting are necessary conditions for obtaining stabilized and strong fluorescence from aqueous solution of I, and quaternary ammonium salt surfactant can enhance its fluorescence intensity. It also showed that this simple derivative of coumarin can be used as a luminescence labeling reagent for amino acid, amines etc. which has reactivity with SO₂Cl group.

Fenxi Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C8H8BFO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shizhong published the artcilePreliminary study on 6-coumarinsulfonyl chloride as luminescence labeling reagent, Application of Coumarin-6-sulfonyl chloride, the publication is Fenxi Ceshi Xuebao (1993), 12(3), 49-52, database is CAplus.

Excessive 6-coumarinsulfonyl chloride (C6SCL) is reacted with L-alanine in pH 9.11 buffer solution (H₃BO₃-NaOH) at 40°C for 40 min and the reaction mixture is extracted with Et acetate. When the extract is dropped on a polyamide membrane and developed with formic acid-water (1 + 1) solution, the alanine C6SCL derivative is separated The R_f value is 0.67, 0.47 and 0.50 for the derivative, C6SCL and C6SOH, resp. After spraying the spot of derivative with 1 mol L^-1 NaOH solution and pre-illuminating and drying under UV light for 10 min, fluorescence intensity of the spot has a good linear relationship with amount of alanine in the range of (4-60) × 10^-11 mol. In addition, more intensive room temperature phosphorescence (RTP) of the derivation is induced by using 1.0 mol/L Pb(OAc)₂ as the heavy atom perturber and filter paper as solid substrate. All results show that the C₆SCL can be expected to serve as not only a fluorescence labeling reagent, but also a RTP one for amino acid etc.

Fenxi Ceshi Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C10H10O2, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Delzenne, Gerard A. published the artcilePhotosensitive polymers. I. Synthesis and properties of coumarin-modified polymers, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Industrie Chimique Belge (1967), 32(Spec. No.), 373-8, database is CAplus.

Polymers containing intramol. cinnamic esters of the coumarin type were synthesized by treating a poly(hydroxy ether) or partially hydrolyzed poly(vinyl butyral) with 6-coumarincarbonyl chloride, 6-coumarinsulfonyl chloride, or 7-coumarinyl 3-(chlorocarbonyl)-benzenesulfonate. A coumarin-containing copolymer was obtained by copolymerization of Et acrylate and 7-(acryloyloxy)coumarin. The photodimerization of coumarin functions by formation of a cyclobutane structure was useful for imagewise insolubilization of polymers. The photosensitivity of these polymers was compared with the sensitivity of poly(vinyl cinnamate). There was a linear relationship between the light sensitivity of the polymers and the degree of coumarin substitution. The photosensitivity can be enhanced by the addition of sensitizers of the carbonyl type. The more powerful sensitizer seems to be p,p’-bis(dimethylamino)-benzophenone. The sensitization was attributed to a triplet-triplet energy transfer between the light-excited sensitizers and the coumarin units.

Industrie Chimique Belge published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdeen, Sanofar published the artcileSulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA), Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2018), 61(16), 7345-7357, database is CAplus and MEDLINE.

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-sym. bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asym. analogs of this scaffold against a panel of bacteria known as the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). While GroEL/ES inhibitors were largely ineffective against K. pneumoniae, A. baumannii, P. aeruginosa, and E. cloacae (Gram-neg. bacteria), many analogs were potent inhibitors of E. faecium and S. aureus proliferation (Gram-pos. bacteria – EC₅₀ values of the most potent analogs were in the 1-2 μM range). Furthermore, even though some compounds inhibit human HSP60/10 biochem. functions in vitro (IC₅₀ values in the 1-10 μM range), many of these exhibited moderate to low cytotoxicity to human liver and kidney cells (CC₅₀ values >20 μM).

Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics