Category: 106-39-8

Adding a certain compound to certain chemical reactions, such as: 106-39-8, name is 1-Bromo-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106-39-8, Quality Control of 1-Bromo-4-chlorobenzene

General procedure: The catalytic o-arylation reaction was carried out in a magnetically stirred round bottom flask (capacity: 25 cm3), at the following reaction conditions: reaction mixture = 1 mmol aryl halides + 1.2 mmol phenol or naphthol + 3 ml solvent (DMF) + catalyst (50 mg), bath temperature = 140 C and reaction time = 7-15 h. The reaction was monitored by TLC. After completion of the reaction, the catalyst was separated by filtration and the filtrate was treated with water, followed by extraction with ethyl acetate to give the crude product, which was subsequently purified by column chromatography on silica gel with petroleum ether/ethyl acetate as eluent. The catalyst was further washed with acetone, dried and reused. The reaction product was isolated by column chromatography and was characterized by comparison of its NMR spectra with that reported earlier.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Choudhary; Dumbre; Yadav; Bhargava; Catalysis Communications; vol. 29; (2012); p. 132 – 136;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 106-39-8,Some common heterocyclic compound, 106-39-8, name is 1-Bromo-4-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At room temperature, to a suitable solvent(a mixture of 1-Sulfobutyl-3-methylimidazolium trifluoromethansulfonate and 1,4-dioxane of volume ration 1:8),add add 100 mmol compound of the above formula (1), 180 mmol compound of the above formula (II), 7 mmol of a catalyst (2mmol of Pd (TFA) 2 and 5 mmol of CuBr), 10mmol of the bipyridine organic ligand of formula L3 and 20 mmol of trifluoroacetic acid, and then the temperature was raised to 80 C and the reaction was stirred at this temperature for 4 hours. After the reaction, The resulting reaction system is cooled to room temperature and filtered filtrate is saturated with sodium bicarbonate aqueous solution till no bubble remain. The acetone was extracted and the organic phase was separated and dried over anhydrous magnesium sulfate and distilled under pressure, the resulting residue was purified by flash column chromatography (elution solvent mixture of petroleum ether and ethyl acetate in a volume ratio of 15: 1) to give a compound of formula (III) ,yield of 96.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-chlorobenzene, its application will become more common.

Reference:
Patent; Jiang Yulan; Li Meiling; Han Deyu; Zheng Xuemei; (10 pag.)CN105152826; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 106-39-8, name is 1-Bromo-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106-39-8, Recommanded Product: 106-39-8

General procedure: A Schlenk flask was charged with an appropriate amount of complex 2b (0.016mmol, 2.0mol%) and the corresponding bromo or iodo arene (0.77mmol). The flask was cycled with nitrogen and vacuum. Afterwards a THF solution of benzylzinc bromide (2.2mL, 1.1mmol, 0.5M in THF) was added. The flask was sealed and heated at 70C for 24h. After that time, the mixture was cooled, and dichloromethane and water were added. The aqueous layer was extracted with dichloromethane and the collected organic layers were washed with water and dried with Na2SO4. The coupling product was confirmed by GC-MS (with n-dodecane as internal standard) and NMR analysis. The analytical properties of the products are in agreement with literature data [6a,24].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Someya, Chika I.; Irran, Elisabeth; Enthaler, Stephan; Inorganica Chimica Acta; vol. 421; (2014); p. 136 – 144;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106-39-8, name is 1-Bromo-4-chlorobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-4-chlorobenzene

A flame-dried Schlenk flask was charged with tris(dibenzylideneacetone)palladium (4.6 mg, 0.005 mmol), 1 (4.4 mg, 0.025 mmol) or 6a (11.9 mg, 0.025 mmol), sodium terf-butoxide (134 mg, 1.40 mmol) and toluene (2.0 ml_) under nitrogen. Aryl bromide (1.00 mmol) and amine (1.10 mmol) were added and the resulting red solution heated at 800C with rapid stirring until reaction was complete, as judged by GC analysis. The reaction mixture was allowed to cool to room temperature, diluted with diethyl ether, passed through celite and the solvent removed to leave a yellow solid. Known products were characterised by NMR spectroscopy and mass spectrometry and unknown products by NMR spectroscopy, mass spectrometry and high resolution mass spectrometry (HRMS). The conversions were calculated using GC analysis as an average over three repeats.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY OF NEWCASTLE UPON TYNE; WO2009/138708; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics