On June 30, 2009, Kureshy, Rukhsana I.; Prathap, K. Jeya; Agrawal, Santosh; Kumar, Manish; Khan, Noor-ul H.; Abdi, Sayed H. R.; Bajaj, Hari C. published an article.HPLC of Formula: 1072792-33-6 The title of the article was Highly Efficient Recyclable CoIII-salen Complexes in the Catalyzed Asymmetric Aminolytic Kinetic Resolution of Aryloxy/Terminal Epoxides for the Simultaneous Production of N-Protected 1,2-Amino Alcohols and the Corresponding Epoxides in High Optical Purity. And the article contained the following:
Chiral CoIII-salen complexes bearing different substituents at the 3,3′- and 5,5′-positions of the salen unit, namely H, t-Bu, morpholinomethyl, and piperidinomethyl, have been synthesized. These complexes were used as catalysts in an environmentally benign protocol for the highly enantioselective aminolytic kinetic resolution (AKR) of racemic aryloxy/terminal epoxides with various carbamates as the nucleophile in the presence of different ionic liquids at room temperature Excellent yields (>99% with respect to the nucleophile) of N-protected 1,2-amino alcs. with high regio- and enantioselectivities (ee >99 %) were achieved with the simultaneous formation of the corresponding epoxides with high chiral purity (ee up to >99%) and in quant. yields with t-Bu-substituted Co(III)-salen complex in the ionic liquid [bmim]PF6 as the reaction medium in around 5 h. The catalyst is recyclable in this ionic-liquid-mediated AKR process (up to six cycles with no loss of performance), and the process is five times faster than the homogeneous process performed with conventional organic solvents.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009). The experimental process involved the reaction of tert-Butyl (R)-(3-chloro-2-hydroxypropyl)carbamate(cas: 1072792-33-6).HPLC of Formula: 1072792-33-6
The Article related to aryloxy epoxide terminal asym kinetic resolution aminolysis cobalt salen, epoxide chiral asym synthesis, alc amino protected asym synthesis, cobalt salen complex catalyst asym aminolytic kinetic resolution epoxide and other aspects.HPLC of Formula: 1072792-33-6
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