Category: 1072952-42-1

Huang, Hongbing published the artcileStructure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer’s disease, Recommanded Product: (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, the publication is Journal of Medicinal Chemistry (2012), 55(21), 9156-9169, database is CAplus and MEDLINE.

A structure- and property-based drug design approach was employed to identify aminooxazoline xanthenes as potent and selective human β-secretase inhibitors. These compounds exhibited good isolated enzyme, cell potency, and selectivity against the structurally related aspartyl protease cathepsin D. Our efforts resulted in the identification of a potent, orally bioavailable CNS penetrant compound that exhibited in vivo efficacy. A single oral dose of compound (I) resulted in a significant reduction of CNS Aβ40 in naive rats.

Journal of Medicinal Chemistry published new progress about 1072952-42-1. 1072952-42-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, Recommanded Product: (5-Chloro-2-fluoro-4-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ni, Nanting published the artcileInhibition of quorum sensing in Vibrio harveyi by boronic acids, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, the publication is Chemical Biology & Drug Design (2009), 74(1), 51-56, database is CAplus and MEDLINE.

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chems. called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathol. relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. Here, the authors describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC₅₀ values in the low to sub-micromolar range in whole cell assays.

Chemical Biology & Drug Design published new progress about 1072952-42-1. 1072952-42-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ni, Nanting published the artcileInhibition of quorum sensing in Vibrio harveyi by boronic acids, COA of Formula: C7H7BClFO2, the main research area is boronate inhibition quorum sensing Vibrio.

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chems. called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathol. relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. Here, the authors describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC50 values in the low to sub-micromolar range in whole cell assays.

Chemical Biology & Drug Design published new progress about Quorum sensing. 1072952-42-1 belongs to class chlorides-buliding-blocks, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, COA of Formula: C7H7BClFO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Hongbing published the artcileStructure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer’s disease, Related Products of chlorides-buliding-blocks, the main research area is aminooxazoline xanthene synthesis CNS penetrable antialzheimer agent structure activity; crystal structure aminooxazoline xanthene BACE beta secretase inhibitor pharmacokinetic; ketone demethylation methylation etherification acylation olefination cyclization Suzuki coupling.

A structure- and property-based drug design approach was employed to identify aminooxazoline xanthenes as potent and selective human β-secretase inhibitors. These compounds exhibited good isolated enzyme, cell potency, and selectivity against the structurally related aspartyl protease cathepsin D. Our efforts resulted in the identification of a potent, orally bioavailable CNS penetrant compound that exhibited in vivo efficacy. A single oral dose of compound (I) resulted in a significant reduction of CNS Aβ40 in naive rats.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 1072952-42-1 belongs to class chlorides-buliding-blocks, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics