Category: 108-70-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-70-3, name is 1,3,5-Trichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H3Cl3

In a nitrogen-filled glove box, a 50 mL pressure flask wascharged with 1,3,5-trichlorobenzene (13.68 g, 75.40 mmol),0.67 mL of chloroform (1.00 g, 8.37 mmol), aluminum trichloride(1.22 g, 9.14 mmol), and a magnetic stir bar. This mixture washeated to 90 C for 2 h under an atmosphere of nitrogen. After thistime the mixture was allowed to cool to room temperature and 20 ml of HCl (0.1N) was added drop-wise over this mixture whichwas cooled in an ice bath. The purple suspension immediatelyturned into a yellow solution that was then extracted from theaqueous byproducts using 50 mL of chloroform in a separatoryfunnel. The organic layer was dried over magnesium sulfate for 1 hand filtered over a scintillated glass frit. The yellow solution wasimmediately concentrated under vacuum and the obtained oilymaterial was added to 40 mL of hexanes which resulted in theimmediate precipitation of a white solid. The solid was collected ona frit, and washed with hexanes until the washings were colorless.The white solid was dried under vacuum to get an 80% yield whichwas used in the next step without further purification. m.p. 246-248C. 1H NMR (400 MHz) (CDCl3): d 6.68 (s, 1H, CHPh), 7.23e7.24(d, 3H, J 2.3 Hz), 7.35e7.36 (d, 3H, J 2.3 Hz). 13C NMR(100.61 MHz): delta 49.80(CH), 128.43, 130.00, 133.78,133.82, 137.07,137.90. The synthesis has been modified slightly and the purificationprocess as well. Characterization data of this compound is inagreement with those reported in the literature [16].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 108-70-3.

Reference:
Article; Neier, Eric; Arias Ugarte, Renzo; Rady, Nader; Venkatesan, Swaminathan; Hudnall, Todd W.; Zakhidov, Alexander; Organic electronics; vol. 44; (2017); p. 126 – 131;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, molecular formula is C6H3Cl3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1,3,5-Trichlorobenzene

General procedure: An oven-dried and argon-flushed pressure tube was charged with 1,3,5-trichlorobenzene, 1,2,4-trichlorobenzene or 1,2,3-trichlorobenzene (0.25 mmol), Pd2(dba)2 (1.25 mol%), cataCXium A (5.0 mol%), boronic acid (1.5 mmol) and K3PO4 (1.5 mmol) followed by anhydrous toluene (4.0 mL). The tube was sealed with a Teflon valve and the reaction mixture was stirred at 110 C for 24 h. The cooled reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried (Na2SO4), filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108-70-3, its application will become more common.

Reference:
Article; Reimann, Sebastian; Ehlers, Peter; Sharif, Muhammad; Spannenberg, Anke; Langer, Peter; Tetrahedron; vol. 72; 8; (2016); p. 1083 – 1094;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 108-70-3, These common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried and argon-flushed pressure tube was charged with 1,3,5-trichlorobenzene, 1,2,4-trichlorobenzene or 1,2,3-trichlorobenzene (0.25 mmol), Pd2(dba)2 (1.25 mol%), cataCXium A (5.0 mol%), boronic acid (1.5 mmol) and K3PO4 (1.5 mmol) followed by anhydrous toluene (4.0 mL). The tube was sealed with a Teflon valve and the reaction mixture was stirred at 110 C for 24 h. The cooled reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried (Na2SO4), filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography.

Statistics shows that 1,3,5-Trichlorobenzene is playing an increasingly important role. we look forward to future research findings about 108-70-3.

Reference:
Article; Reimann, Sebastian; Ehlers, Peter; Sharif, Muhammad; Spannenberg, Anke; Langer, Peter; Tetrahedron; vol. 72; 8; (2016); p. 1083 – 1094;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 108-70-3, name is 1,3,5-Trichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108-70-3, Application In Synthesis of 1,3,5-Trichlorobenzene

Step 2: Preparation of (3,5-dichloro-4-pyridinyl)bis(2,4,6-trichlorophenyl)methane A 100 mL round-bottom flask was charged with 3,5-dichloropyridine-4-aldehye (1.76 g, 10.0 mmol), 1,3,5-trichlorobenzene (18.14 g, 100 mmol) and trifluoromethanesulphonic acid (30.0 g, 200 mmol) and heated to 180 C. for 10 h. After the reaction was completed and cooled to room temperature, the mixture was dissolved with dichloromethane and added to ice water. The mixture was neutralized to pH 7 using saturated sodium hydrogen carbonate solution, extracted with dichloromethane, washed with a sodium hydrogen carbonate solution several times, dried over magnesium sulphate. The solvent was evaporated under the reduced pressure. Product was purified by silica gel chromatography eluting with petroleum ether:methylene dichloride=1:1 (VV). A white solid (2.6 g, 50%) was obtained. 1H NMR and mass spectrometry results confirmed that product was (3,5-dichloro-4-pyridine)bis(2,4,6-trichlorophenyl)methane.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Trichlorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; JILIN UNIVERSITY; LI, Feng; (18 pag.)US2016/99415; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 108-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108-70-3, name is 1,3,5-Trichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

n-Butyllithium (2.45 mL, 4.00 mmol) was added to a tetrahydrofuran (10 mL) solution of 1,3,5-trichlorobenzene(724 mg, 4.00 mmol) at -78C in an argon atmosphere, and the mixture was stirred for 45 minutes.[0146] After the addition of dimethylformamide (0.31 mL, 4.00 mmol) at -78C, the mixture was stirred for 45 minutes.[0147] After increasing the temperature of the mixture to -20C, a saturated ammonium chloride solution (5 mL) wasadded to the mixture, followed by stirring for 5 minutes.[0148] The organic layer was extracted with ethyl acetate, dried over sodium sulfate, and filtered, and the solvent wasevaporated.[0149] The residue was purified by silica gel column chromatography (15 g, hexane_acetone=50:1 to 40:1) to obtaina 2,4,6-trichlorobenzaldehyde compound (colorless crystals) (633 mg, 76%).Reference: Synthesis, 2008, 279-285.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5-Trichlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; National University Corporation University Of Toyama; MORI Hisashi; TOYOOKA Naoki; MIZUGUCHI Mineyuki; OBITA Takayuki; HIRONO Syuichi; GODA Hiroaki; EP2808014; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 108-70-3,Some common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, molecular formula is C6H3Cl3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1; [0099] 3,5-Dichlorophenyl-isopropylsulfide (2); EMI20.0[0100] Method A; [0101] To a solution of 4N sodium hydroxide (0.8 ml) was added isopropylmercaptan (0.33 ml). The mixture was stirred for 10 minutes at room temperature. 1,3,5-Trichlorobenzene(1) (1.8 g, 10 mmol) and tetra n-butylammoniumbromide (322 mg, 1 mmol) were added thereto. The reaction mixture was refluxed under vigorous stirring at 140[deg.] C. for 5.5 hours. The reaction mixture was poured into ice-water, extracted with ethylacetate, washed with water, dried over sodium sulphate, filtrated and concentrated under reduced pressure. The obtained residue was chromatographed twice on silica gel (SiO2 18 g, elution: n-hexane) to yield the objective (2) (566 mg). Yield 85%. [0102] IR(film) 1555, 1400, 1375, 1360, 1155 cm<-1>. [0103] <1>H-NMR (CDCl3, 200 MHz) [delta]: 1.32 (6H, d, J=6.4 Hz), 3.42 (1H, sept, J=6.4 Hz), 7.15-7.25 (3H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Trichlorobenzene, its application will become more common.

Reference:
Patent; Aoki, Tsutomu; Konoike, Toshiro; US2003/195363; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 108-70-3, These common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a reaction tube was added bis-bis [(1,2,3) -1-phenyl-2-propene] dipalladium(0.005 mmol) and 2-di-tert-butylphosphino-2?,4?,6?-triisopropylbiphenyl(0.02 mmol)Join 1mL1,4-dioxane solvent for 20-60 minutes can be stirred, Raw material 1,3,5-trichlorobenzene (0.5mmol), sodium tert-butoxide (2.25mmol), ammonium sulfate (0.75mmol) placed in a sealed tube, evacuated with nitrogen gas protection, and then has been coordinated The catalyst, then add 0.4mol / L ammonia 1,4-dioxane solution 2mL, finally adding 3mL solvent, sealing the sealed tube, heated to 100 C and stirred for 24h, after completion of the reaction by GCMS detection of raw materials have been completed. The reaction was terminated by adding 5mL of water diluted with tert-butyl methyl ether 5mL extracted three times, then add hydrochloric acid to adjust pH 11, extracted with tert-butyl methyl ether 5mL, The product gave the product 3,5-dichloroaniline (75 mg, 93%).

Statistics shows that 1,3,5-Trichlorobenzene is playing an increasingly important role. we look forward to future research findings about 108-70-3.

Reference:
Patent; East China Normal University; Xiao Yuanjing; Zhou Xiaofan; Hu Anjing; Cheng Huayu; Li Yongfeng; Zhao Qiuhua; Zhang Junliang; (9 pag.)CN106748801; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 108-70-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108-70-3 as follows.

1-Bromopropane (25 g, 0.20 mol) was added dropwise to a mixture of Mg (5.0 g, 0.21 mol) in diethyl ether (100 mL) at room temperature. The mixture was refluxed for 2 h and then cooled to room temperature. The new prepared Grignard reagent was then added to a mixture of 1,3,5-trichlorobenzene (10.4 g, 570 mmol) and Ni(dppe)Cl2 (75 mg, 0.14 mmol) in 100 mL of diethyl ether at room temperature. The mixture was stirred overnight and quenched by adding a saturated aqueous NH4Cl. The resulting mixture was extracted with ether, and washed with deionized water. The organic layer was separated and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography to give 1,3,5-trialkylbenzene (9.75 g, 84%) as a colorless oil.

According to the analysis of related databases, 108-70-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Taoping; Zhao, Xiaoming; Shen, Qilong; Lu, Long; Tetrahedron; vol. 68; 32; (2012); p. 6535 – 6547;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 108-70-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108-70-3 as follows.

1-Bromopropane (25 g, 0.20 mol) was added dropwise to a mixture of Mg (5.0 g, 0.21 mol) in diethyl ether (100 mL) at room temperature. The mixture was refluxed for 2 h and then cooled to room temperature. The new prepared Grignard reagent was then added to a mixture of 1,3,5-trichlorobenzene (10.4 g, 570 mmol) and Ni(dppe)Cl2 (75 mg, 0.14 mmol) in 100 mL of diethyl ether at room temperature. The mixture was stirred overnight and quenched by adding a saturated aqueous NH4Cl. The resulting mixture was extracted with ether, and washed with deionized water. The organic layer was separated and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography to give 1,3,5-trialkylbenzene (9.75 g, 84%) as a colorless oil.

According to the analysis of related databases, 108-70-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Taoping; Zhao, Xiaoming; Shen, Qilong; Lu, Long; Tetrahedron; vol. 68; 32; (2012); p. 6535 – 6547;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108-70-3, name is 1,3,5-Trichlorobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H3Cl3

To a 250 ml one-necked flask was added 10.0 g (55.1 mmol) of 1,3,5-trichlorobenzene and 100 ml of ultra-dry tetrahydrofuran under argon gas protection and minus 78 degrees Celsius. Then, 23 ml (2.4 M, 55.2 mmol) of n-butyllithium in n-hexane was added dropwise, and the mixture was stirred at minus 78 C for 30 minutes. Then, 7.44 ml (107.3 mmol) of ultra-dry DMF was added dropwise, and stirring was continued for 1.5 hours at minus 78 C. The reaction was then slowly warmed to room temperature and quenched by the addition of 200 mL (3M) hydrochloric acid. The combined organic layers were washed with brine (25 mL) After evaporating the solvent, it was purified by column chromatography using methylene chloride: petroleum ether 1:1 (yield ratio) as eluent to afford 11.0 g of product A1, yield 95%.

The synthetic route of 108-70-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jilin University; Li Feng; Ai Xin; Zhang Ming; (25 pag.)CN108191739; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics