Category: 108047-39-8

Application of 108047-39-8, These common heterocyclic compound, 108047-39-8, name is 2-(Aminomethyl)-4-chloroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of the amine of preparation 10 (6. 4 g, 41 MMOL) in tetrahydrofuran (50 ML) was added to a solution of the oxadiazole of preparation 5 (4.56 g, 16 MMOL) in tetrahydrofuran (50 ML) and the mixture was heated to 50 C for 18 hours. The reaction mixture was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using methanol in DICHLOROMETHANE as eluant (5: 95), to give the title compound as a white solid (4.65 g). APCI MS M/Z 399 [MH] + ‘H NMR (400MHZ, CDCI3) : 8 1.95 (m, 2H), 2.20 (m, 2H), 3.10 (m, 2H), 3.20 (m, 1H), 3.80 (s, 2H), 4.00 (s, 2H), 4.30 (m, 2H), 6.60 (m, 1H), 6.65 (t, 1H), 6.70 (d, 1H), 7.00 (s, 1H), 7.05 (d, 1H), 7.50 (t, 1H), 8.20 (d, 1H)

The synthetic route of 108047-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 108047-39-8, These common heterocyclic compound, 108047-39-8, name is 2-(Aminomethyl)-4-chloroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of the amine of preparation 10 (6. 4 g, 41 MMOL) in tetrahydrofuran (50 ML) was added to a solution of the oxadiazole of preparation 5 (4.56 g, 16 MMOL) in tetrahydrofuran (50 ML) and the mixture was heated to 50 C for 18 hours. The reaction mixture was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using methanol in DICHLOROMETHANE as eluant (5: 95), to give the title compound as a white solid (4.65 g). APCI MS M/Z 399 [MH] + ‘H NMR (400MHZ, CDCI3) : 8 1.95 (m, 2H), 2.20 (m, 2H), 3.10 (m, 2H), 3.20 (m, 1H), 3.80 (s, 2H), 4.00 (s, 2H), 4.30 (m, 2H), 6.60 (m, 1H), 6.65 (t, 1H), 6.70 (d, 1H), 7.00 (s, 1H), 7.05 (d, 1H), 7.50 (t, 1H), 8.20 (d, 1H)

The synthetic route of 108047-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 108047-39-8, name is 2-(Aminomethyl)-4-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108047-39-8, Safety of 2-(Aminomethyl)-4-chloroaniline

A solution of the amine of preparation 10 (4.12 g, 26 MMOL) in tetrahydrofuran (50 mi) was added to a solution of the oxadiazole of preparation 6 (2.95 g, 11 MMOL) in tetrahydrofuran (50 ml) and heated to 50 C for 18 hours. The reaction mixture was evaporated under reduced pressure and the residue purified by chromatography on silica gel using ethyl acetate as eluant to give the title compound as an off-white solid (2.34 g). APCI MS M/Z 400 [MH] H NMR (400MHZ, CDCI3) : 5 1.80 (m, 2H), 2.20 (m, 2H), 3.20 (m, 3H), 3.80 (s, 2H), 4.00 (s, 2H), 4.75 (m, 2H), 6.50 (t, 1H), 6.60 (d, 1H), 7.00 (d, 1H), 7.05 (d, 1H), 8.35 (d, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics