Category: 1096296-85-3

Adding a certain compound to certain chemical reactions, such as: 1096296-85-3, name is (5-Bromo-2-chlorophenyl)methanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1096296-85-3, COA of Formula: C7H7BrClN

To a solution of 5-bromo-2-chlorobenzenemethanamine (i.e. the product of Step A) (600 mg, 2.72 mmol) in toluene (10 mL) at 0 C was added acetic anhydride (0.55 mL, 5.45 mmol). The reaction mixture was stirred at 100 C for 3 h. The reaction mixture was then extracted with ethyl acetate (3x), and the organic layers were combined, washed with water and brine and dried (Na2S04). The solvent was evaporated to provide the title product (600 mg).il NMR (CDCI3) delta 1.9 (s, 3H), 4.3 (d, 2H), 7.4 (d, 1H), 7.5 (m, 2H), 8.4 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (5-Bromo-2-chlorophenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. I. du Pont de Nemours and Company; ANDREASSI II, John Lawrence; TAGGI, Andrew, Edmund; WO2011/59619; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1096296-85-3, A common heterocyclic compound, 1096296-85-3, name is (5-Bromo-2-chlorophenyl)methanamine, molecular formula is C7H7BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (5-bromo-2-chloro-phenyl)methanamine (6.5 g, 29.7 mmol) and triethylamine (TEA) (6 g, 59.4 mmol) in CH2CI2 was added methyl chloroformiate (3.35 g, 35.6 mmol) dropwise at 0 C. Then the reaction mixture was stirred at 25C for 10 hours. The reaction mixture was concentrated, diluted with EtOAc(300 mL), washed with brine, and dried over Na2S04. Concentration under reduced pressure gave methyl N-[(5-bromo-2-chloro- phenyl)methyl]carbamate (4 g, yield 49%).

The synthetic route of 1096296-85-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; WINTER, Christian; RHEINHEIMER, Joachim; WOLF, Antje; TERTERYAN, Violeta; POONOTH, Manojkumar; WIEBE, Christine; KREMZOW-GRAW, Doris; ROeHL, Franz; ROHRER, Sebastian Georgios; WIEJA, Andy; ROSENBAUM, Claudia; GRAMMENOS, Wassilios; WO2014/202703; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics