Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1099597-32-6, name is 2-Bromo-4-chlorobenzotrifluoride, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H3BrClF3
A mixture of Pd(PPh3)4 (2.20 g, 1 .94 mmol), Cul (0.74 g, 3.88 mmol), 2-bromo-4-chloro- 1 -(trifluoromethyl)benzene (Int 5a) (10.00 g, 38.76 mmol) and ethynyltrimethylsilane (13.30 g, 135.66 mmol) in TEA was stirred at 70 C overnight. The mixture was concentrated, EtOAc (200 mL) was added and the mixture was filtered through celite. The mixture was concentrated to dryness and the residue was purified by column chromatography (Hexane) to give the title compound as a yellow oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; DEUSCHLE, UIrich; STEENECK, Christoph; ALBERS, Michael; HOFFMANN, Thomas; (62 pag.)WO2018/153893; (2018); A1;,
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