Category: 112-26-5

Related Products of 112-26-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a 50 mL round bottom flask imidazole (32 mmol, 2.176 g) and potassium hydroxide (32 mmol, 1.792 g) were dissolved in DMSO (25 mL). The mixture was stirred at 70 for 1 h. After this time, 1,1?-oxybis(2-chloro-ethan (16 mmol, 1.88 ml) was added into the solution and stirred for 24 h under nitrogen atomosphere to complete the reaction which was monitored by TLC. The resulting mixture was poured into 100 mL of water and extracted with methylene chloride (5×20 mL). The combined organic layer was washed with water (3×20mL), dried over Na2SO4 and concentrated to give the crude product, which was further purified by column chromatography over silica gel using CH2Cl2 as eluent to give 1a as a pale yellow viscous oil (2.04 g, Yield = 62% ).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhou, Ji; Yuan, Yao-Feng; Zhuo, Ji-Bin; Lin, Cai-Xia; Tetrahedron Letters; vol. 59; 11; (2018); p. 1059 – 1064;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-26-5, Application In Synthesis of 1,2-Bis(2-chloroethoxy)ethane

7.7Ig (50 mmo 1) of 2,6-dimethoxyphenol and 8.42 g (45 mmol) of 1,2- (dichloroethane) ethane were added to IOOml of acetonitrile at a temperature of 20 C with stirring , 6.06 g (108 mmol) of potassium hydroxide was added thereto, and the temperature was raised to 82 C. After 92 hours of reaction, acetonitrile was distilled off at atmospheric pressure to obtain orange turbid liquid.[0027] IOOml dichloromethane was added to the above-mentioned orange turbid liquid 1, the insoluble matter was filtered off, washed twice with 50 ml of IM sodium hydroxide solution and twice with saturated sodium chloride solution (20 C) Dried over anhydrous magnesium sulfate and evaporated to dryness at atmospheric pressure to give a yellow oily liquid 2;[0028] To the above yellow oily liquid 3 was added 25 ml of diethyl ether, the temperature was raised to 35 C, the insoluble matter was filtered off, cooled to _15 C, cooled for 3 hours, the liquid was stratified, and the pale yellow solution was taken and cooled to -15 C (2- (2,6-dimethoxyphenoxy) ethoxy) ethane in a yield of 69.33% and a purity of 98.42% as a white powder

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xi’an Modern Chemical Institute; Lu Tingting; Ji Yueping; Zhang Lijie; Liu Yajing; Wang Wei; Pan Yongfei; Xu Minghui; Mo Hongchang; Lu Xianming; Ding Feng; (6 pag.)CN106946664; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 112-26-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The synthesis of benzoaza-12-crown-4 is based on the condensation process of o-aminophenol with triethylene glycol dichloride in the presence of sodium hydroxide in the isopropanol medium. 17.4 g of o-aminophenol (0.16 mol) and 12.6 g of sodium hydroxide in 200 ml of isopropanol are placed into a flask, mechanically stirred, and kept at a temperature of 60 C for 60 min. After this 25 ml (0.16 mol) of triethylene glycol dichloride are dropped. The reaction mixture is kept boiling for 20 h. Then the mixture is cooled, acidified with hydrochloric acid to pH 3-4, filtered from inorganic impurities, alkalized with 25% ammonium hydroxide to pH 8-9, and evaporated on a rotary evaporator. The technical product obtained is distilled under vacuum and the high-boiling fraction is separated at a temperature of 150 C and pressure of 6 mm of mercury. The fraction is placed into a sealed vessel and kept at room temperature until the substance transition to the crystalline state. After crystallization the crystals are isolated, washed with acetone, and dried in the air. The product yield is 49 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Glushko; Sadovskaya; Blokhina; Anan’Ev; Journal of Structural Chemistry; vol. 56; 1; (2015); p. 142 – 147; Zh. Strukt. Kim.; vol. 56; 1; (2015); p. 149 – 154,6;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 112-26-5,Some common heterocyclic compound, 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, molecular formula is C6H12Cl2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthesis of precursor P4 was realized by a Williamsonether procedure. To a solution of 1.50 g (9.92 mmol) of 4-(acetylamino)phenol (1) in anhydrous DMF (30 mL) andinert N2 atmosphere, were added 10.0 equivalents of anhydrousK2CO3, whereupon the mixture was stirred over30 minutes at 120C. Subsequently were added 755 mul(4.90 mmol) of 1,2-bis(2-chloroethoxy)ethane (P2) and 1.0equivalent of KI. The mixture was maintained with stirringover a twelve-hour period at 120C. Finally, the mixture wasfiltered in order to remove the salt, then the solvent wasevaporated in vacuum and acetone was added. A precipitatewas obtained, which was filtered, washed with acetoneand then with water and vacuumdried to give a whitesolid. Yield: 1.83 g (90%). Melting point: 160-161C. IR (KBr,nu, cm-1): 3306, 1659, 1594, 1530, 1243. 1H NMR (400 MHz,DMSO-d6, delta, ppm, J, Hz): 9.84 (s, 2H, H-8), 7.45 (d, J= 9.0, 4H,H-6), 6.84 (d, J =9.0, 4H,H-5), 4.02 (t, J = 4.7, 4H, H-3), 3.71 (t,J = 4.7, 4H, H-2), 3.60 (s, 4H, H-1), 1.99 (s, 6H, H-10). 13CNMR(101 MHz, DMSO-d6, delta, ppm): 167.7 (C-9), 154.2 (C-4), 132.6(C-7), 120.5 (C-6), 114.4 (C-5), 69.9 (C-1), 69.0 (C-2), 67.2 (C-3),23.8 (C-10). ESI-MS: m/z (positive ion mode) 416.9 [M + H]+(28.55%), 454.9 [M + K]+ (82.30%), 871.9 [2M+K]+ (23.92%).Elem. Anal. Calcd for C22H28N2O6.H2O: C, 60.82; H, 6.96; N,6.45; O, 25.78. Found: C, 60.9; H, 6.37; N, 6.23.

The synthetic route of 112-26-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gomez-Vega, Jancarlo; Moreno-Corral, Ramon Alfonso; Santacruz Ortega, Hisila; Corona-Martinez, David Octavio; Hoepfl, Herbert; Sotelo-Mundo, Rogerio R.; Ochoa-Teran, Adrian; Escobar-Picos, Raymundo Enrique; Ramirez-Ramirez, Jose Zeferino; Juarez-Sanchez, Octavio; Lara, Karen Ochoa; Supramolecular Chemistry; vol. 31; 5; (2019); p. 322 – 335;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-26-5, HPLC of Formula: C6H12Cl2O2

A mixture of imidazole (32 mmol, 2.176 g) and potassium hydroxide (32 mmol, 1.792 g) in DMSO (25 ml) was stirred at 70 C for 1 h. After this time, 1,2-bis(2-chloroethoxy)ethane (16 mmol, 2.48 ml) was added to the reaction mixture and stirred for 24 h. The resulting mixture was poured into 100 mL of water and extracted with methylene chloride (5 x 20 ml). The combined organic layer was washed with water (3 x 20 ml), dried with anhydrous Na2SO4, and concentrated to give 1,2-bis(2-(1H-imidazol-1-yl)ethoxy)ethane (1) as a pale yellow viscous oil, 3.10 g, 77 % yield

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Eshghi, Hossein; Rahimizadeh, Mohammad; Hasanpour, Maede; Bakavoli, Mehdi; Research on Chemical Intermediates; vol. 41; 7; (2015); p. 4187 – 4197;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,2-Bis(2-chloroethoxy)ethane

At a temperature 20 C with stirring, 15.42 g (100 mmol) dimethoxyphenol and 8.42 g (45 mmol) of 1,2- (dichloroethanyl) ethane were added to 100 ml N,N-dimethylformamide, potassium hydroxide was added thereto 6.06g (108mmol), warmed to 153 C, the reaction at 40 h, the solvent was distilled off, the solvent was distilled off can be used directly for the next reaction to give brown Yellow turbid liquid; The above brown turbid liquid is added in 100 ml dichloromethane, filters the insoluble substance, using 50 ml 1 M sodium hydroxide solution washing 3 times, then 50 ml saturated sodium chloride solution (20 C) washing 2 times, water-free magnesium sulfate drying, atmospheric dryness dichloromethane, to obtain yellow oily liquid; To the above-mentioned yellow oily liquid by adding 25 ml ethyl ether, up to 35 C, filtering to remove the insoluble matter, cooling to -15 C, cooling 3 h, liquid layered, taking the upper light yellow solution, cooling to -15 C, cooling 48 h, filtering solution, to obtain 15.26 g of powder of white solid 1,2-bis(2-(2,6-dimethoxyphenoxy)ethoxy)ethane, yield 80.27%, purity 98.42%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 112-26-5.

Reference:
Patent; Xi’an Modern Chemical Institute; Lu Tingting; Lu Xianming; Mo Hongchang; Wang Yinglei; Ji Yueping; Xu Minghui; Gao Fulei; Liu Weixiao; (6 pag.)CN107011128; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 112-26-5, A common heterocyclic compound, 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, molecular formula is C6H12Cl2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

200 ml flask was equipped with a thermometer, and 10.45 g 1,3-diallyl isocyanurate (50.0mmol), 1,2-bis (2-[…])ethane (24.8mmol) 4.63 g, 10.26 g potassium carbonate (74.3mmol) and N, 25 ml dimethylformamide N-charged, the reaction liquid was prepared.After stirring for 12 hours at 110 C reaction, was cooled to room temperature, the insoluble matter was filtered off from the reaction solution. Subsequently, the reaction solution after concentration under reduced pressure, toluene was added 50 ml, 20 ml saline 3 times with saturated, 20 ml distilled water at 1 after the washes, by distilling off the volatile content, 12.32 g (93% yield) was obtained as white solid

The synthetic route of 112-26-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shikoku Chemicals Corporation; Makoto, Matsuda; Kumano, Mt.; Takuma, Takeda; Naoto, Okuura; Rise of groove, Rise of groove; (17 pag.)JP2017/19764; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-26-5, category: chlorides-buliding-blocks

7.7Ig (50 mmo 1) of 2,6-dimethoxyphenol and 8.42 g (45 mmol) of 1,2- (dichloroethane) ethane were added to IOOml of acetonitrile at a temperature of 20 C with stirring , 6.06 g (108 mmol) of potassium hydroxide was added thereto, and the temperature was raised to 82 C. After 92 hours of reaction, acetonitrile was distilled off at atmospheric pressure to obtain orange turbid liquid.[0027] IOOml dichloromethane was added to the above-mentioned orange turbid liquid 1, the insoluble matter was filtered off, washed twice with 50 ml of IM sodium hydroxide solution and twice with saturated sodium chloride solution (20 C) Dried over anhydrous magnesium sulfate and evaporated to dryness at atmospheric pressure to give a yellow oily liquid 2;[0028] To the above yellow oily liquid 3 was added 25 ml of diethyl ether, the temperature was raised to 35 C, the insoluble matter was filtered off, cooled to _15 C, cooled for 3 hours, the liquid was stratified, and the pale yellow solution was taken and cooled to -15 C (2- (2,6-dimethoxyphenoxy) ethoxy) ethane in a yield of 69.33% and a purity of 98.42% as a white powder

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xi’an Modern Chemical Institute; Lu Tingting; Ji Yueping; Zhang Lijie; Liu Yajing; Wang Wei; Pan Yongfei; Xu Minghui; Mo Hongchang; Lu Xianming; Ding Feng; (6 pag.)CN106946664; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 112-26-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The synthesis of benzoaza-12-crown-4 is based on the condensation process of o-aminophenol with triethylene glycol dichloride in the presence of sodium hydroxide in the isopropanol medium. 17.4 g of o-aminophenol (0.16 mol) and 12.6 g of sodium hydroxide in 200 ml of isopropanol are placed into a flask, mechanically stirred, and kept at a temperature of 60 C for 60 min. After this 25 ml (0.16 mol) of triethylene glycol dichloride are dropped. The reaction mixture is kept boiling for 20 h. Then the mixture is cooled, acidified with hydrochloric acid to pH 3-4, filtered from inorganic impurities, alkalized with 25% ammonium hydroxide to pH 8-9, and evaporated on a rotary evaporator. The technical product obtained is distilled under vacuum and the high-boiling fraction is separated at a temperature of 150 C and pressure of 6 mm of mercury. The fraction is placed into a sealed vessel and kept at room temperature until the substance transition to the crystalline state. After crystallization the crystals are isolated, washed with acetone, and dried in the air. The product yield is 49 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Glushko; Sadovskaya; Blokhina; Anan’Ev; Journal of Structural Chemistry; vol. 56; 1; (2015); p. 142 – 147; Zh. Strukt. Kim.; vol. 56; 1; (2015); p. 149 – 154,6;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, A new synthetic method of this compound is introduced below., Formula: C6H12Cl2O2

Potassium carbonate (11.0g, 79.3mmol) in the presence of, at 50 , 4- hydroxythiophenol (1e) (10.0g, 79.3mmol) and 1,2-bis (chloroethoxy) ethane ( the reaction 7.06g, 37.76mmol) in place in DMAc35ml. using ethyl acetate / water system after the separating operation was performed to obtain crystals of the diol was purified by column (2b) (5.7g, 42%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Song, Shantashi; Jia, tengjunye; (56 pag.)CN104159996; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics