Category: 1124-05-6

Electric Literature of 1124-05-6, A common heterocyclic compound, 1124-05-6, name is 2,5-Dichloro-p-xylene, molecular formula is C8H8Cl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of acetic acid (300 g, 5.00 mol, 25.0 equiv), acetic anhydride (600 g, 5.88 mol, 29.4 equiv) and sulfuric acid (90.0 g, 899 mmol, 4.50 equiv, 98%) at 0-10 C was added 1,4- dichloro-2,5-dimethylbenzene (35.0 g. 200 mmol, 1.00 equiv), and followed by addition of chromium trioxide (60.0 g, 600 mmol, 3.00 equiv) in several batches over 2 h. The resulting solution was stirred for 4 h at room temperature, and then quenched by the addition of 2000 mL of crushed ice. The resulting solution was extracted with 3×1000 mL of ethyl acetate and the organic layers were combined and concentrated under reduced pressure to give a solid. The solid was added to a mixture of ethanol (300 mL), water (300 mL), and sulfuric acid (30 mL), and the mixture was heated to reflux for 3 h and then cooled. The solids were collected by filtration. The solid was purified by column with ethyl acetate/petroleum ether (1 :30) to give 12 g (30%) of 2,5- dichloroterephthalaldehyde as a white solid.

The synthetic route of 1124-05-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1124-05-6, name is 2,5-Dichloro-p-xylene, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8Cl2

A mixture of l,4-dichloro-2,5-dimethylbenzene (5 g, 0.03 mol, 1.0 eq), NBS (10.5 g, 0.06 mol) and AIBN (50 mg, 0.3 mmol) in CCL (200 mL) was heated at 85 C under N2 for 2 h. The solvents were evaporated, diluted with water (200 mL) and extracted with DCM (100 mL X 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified via flash chromatography (PE) to afford l,4-bis(bromomethyl)-2,5-dichlorobenzene as a white solid (850 mg, 10%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics