Related Products of 113206-03-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113206-03-4 name is 2-Chloro-3-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(iv) Methyl [[(2-chloro-4-fluorophenyl)methyl](2-oxoethyl)amino](oxo)acetate (0.288 g, 1 mmol, prepared as described earlier) and 2-chloro-3-(methyloxy)aniline (0.315 g,2.00 mmol) were dissolved in 2% acetic acid/methanol (10ml) at room temperature.The mixture was stirred for 15 minutes and polymer-supported cyanoborohydride(0.976 g, 4.00 mmol) was added. The mixture was stirred at room temperature overnight, filtered through an SCX cartridge (Varian, 5g) and concentrated in vacuo to afford methyl [[(2-chloro-4-fluorophenyl)methyl](2-{[2-chloro-3-(methyloxy)phenyl] amino}ethyl)amino](oxo)acetate (0.289 g), which was used without purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon; WO2010/125103; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics