Category: 1138-56-3

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human 尾₃ adrenergic receptor agonists was written by Sum, Fuk-Wah;Wong, Victoria;Han, Stella;Largis, Elwood;Mulvey, Ruth;Tillett, Jeff. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application of 1138-56-3 This article mentions the following:

Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human 尾₃ adrenergic receptor (尾₃-AR) agonists. The azetidine derivative, and piperidine derivatives were found to be potent 尾₃-AR agonists and have good selectivity against 尾₁– and 尾₂-AR. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Application of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli was written by Chan, Michael;Lao, Fitzgerald S.;Chu, Paul J.;Shpigelman, Jonathan;Yao, Shiyin;Nan, Jason;Sato-Kaneko, Fumi;Li, Vicky;Hayashi, Tomoko;Corr, Maripat;Carson, Dennis A.;Cottam, Howard B.;Shukla, Nikunj M.. And the article was included in Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

Agents that safely induce, enhance, or sustain multiple innate immune signaling pathways could be developed as potent vaccine adjuvants or coadjuvants. Using high-throughput screens with cell-based nuclear factor 魏B (NF-魏B) and interferon stimulating response element (ISRE) reporter assays, we identified a bis-aryl sulfonamide bearing compound 1 that demonstrated sustained NF-魏B and ISRE activation after a primary stimulus with lipopolysaccharide or interferon-伪, resp. Here, we present systematic structure-activity relationship (SAR) studies on the two Ph rings and amide nitrogen of the sulfonamide group of compound 1 focused toward identification of affinity probes. The murine vaccination studies showed that compounds 1 and 33 when used as coadjuvants with monophosphoryl lipid A (MPLA) showed significant enhancement in antigen ovalbumin-specific Ig responses compared to MPLA alone. SAR studies pointed to the sites on the scaffold that can tolerate the introduction of aryl azide, biotin, and fluorescent rhodamine substituents to obtain several affinity and photoaffinity probes which will be utilized in concert for future target identification and mechanism of action studies. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies was written by Chawla, Reena;Van Puyenbroeck, Victor;Pflug, Nicholas C.;Sama, Alekhya;Ali, Rameez;Schols, Dominique;Vermeire, Kurt;Bell, Thomas W.. And the article was included in Journal of Medicinal Chemistry in 2016.Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According to a two-site binding model, 28 new unsym. analogs bearing a benzyl tail group and nine bearing a cyclohexylmethyl tail have been designed and synthesized. The most potent new CD4 down-modulator (40 (CK147); IC₅₀ 63 nM) has a 4-dimethylaminobenzenesulfonyl side arm. One of the two side arms was varied with substituents in different positions. This gave a range of CD4 down-modulation potencies that correlated well with anti-HIV-1 activities. The side arms of 21 of the new benzyl-tailed analogs were modeled by means of quantum mech. calculations For CADA analogs with arenesulfonamide side arms, the pIC₅₀ values for CD4 down-modulation correlated with the component of the elec. dipole moment in the aromatic ring, suggesting that an attractive electronic interaction is a major factor determining the stability of the complex between the mol. and its target. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arenesulfonic acid derivatives. XI. Synthesis of sulfonamides, hydrazides, and ureas containing a benzofuran moiety was written by Kaldrikyan, M. A.;Geboyan, V. A.;Aroyan, A. A.;Stepanyan, N. O.;Sapondzyan, L. G.;Sarkisyan, L. M.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1980.Synthetic Route of C10H13ClO3S This article mentions the following:

Sixteen amides I (R, R¹ = Me, Et, Pr, Bu) were obtained in 61-91% yield by reaction of p-ROC₆H₄SO₂Cl (II) with the corresponding benzofuranylalkylamine. Treatment of 2-benzofurancarboxylic hydrazide with II gave 72-80% III, which could also be obtained using the benzofurancarbonyl chloride and p-ROC₆H₄SO₂NHNH₂. Eight IV (R = Me, Et, Pr, Bu; R¹ = Me, Et) were obtained in 45-74% yield by reaction of p-ROC₆H₄SO₂NHCO₂Et with the corresponding benzofuranylalkylamine. The hypoglycemic and anticonvulsive properties of I, III and IV were determined; none exhibited anticonvulsive properties and I (R = R¹ = Pr) reduced blood glucose content by 20% at 250 mg/kg. All the remaining compounds exhibited hyperglycemic activity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core was written by Fotsch, Christopher;Biddlecome, Gloria;Biswas, Kaustav;Chen, Jian Jeff;D’Amico, Derin C.;Groneberg, Robert D.;Han, Nianhe Bruce;Hsieh, Feng-Yin;Kamassah, Augustus;Kumar, Gondi;Lester-Zeiner, Dianna;Liu, Qingyian;Mareska, David A.;Riahi, Babak Bobby;Wang, Yueh-Ju Judy;Yang, Kevin;Zhan, James;Zhu, Joe;Johnson, Eileen;Ng, Gordon;Askew, Benny C.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Related Products of 1138-56-3 This article mentions the following:

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC₅₀s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Related Products of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches was written by Villemagne, Baptiste;Flipo, Marion;Blondiaux, Nicolas;Crauste, Celine;Malaquin, Sandra;Leroux, Florence;Piveteau, Catherine;Villeret, Vincent;Brodin, Priscille;Villoutreix, Bruno O.;Sperandio, Olivier;Soror, Sameh H.;Wohlkonig, Alexandre;Wintjens, Rene;Deprez, Benoit;Baulard, Alain R.;Willand, Nicolas. And the article was included in Journal of Medicinal Chemistry in 2014.Synthetic Route of C10H13ClO3S This article mentions the following:

Tuberculosis remains a major cause of mortality and morbidity, killing each year more than one million people. Although the combined use of first line antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol) is efficient to treat most patients, the rapid emergence of multidrug resistant strains of Mycobacterium tuberculosis stresses the need for alternative therapies. Mycobacterial transcriptional repressor EthR is a key player in the control of second-line drugs bioactivation such as ethionamide and has been shown to impair the sensitivity of the human pathogen Mycobacterium tuberculosis to this antibiotic. As a way to identify new potent ligands of this protein, we have developed fragment-based approaches. In the current study, we combined surface plasmon resonance assay, x-ray crystallog., and ligand efficiency driven design for the rapid discovery and optimization of new chemotypes of EthR ligands starting from a fragment. The design, synthesis, and in vitro and ex vivo activities of these compounds will be discussed. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery and Development of a New Class of Potent, Selective, Orally Active Oxytocin Receptor Antagonists was written by Quattropani, Anna;Dorbais, Jerome;Covini, David;Pittet, Pierre-Andre;Colovray, Veronique;Thomas, Russell J.;Coxhead, Richard;Halazy, Serge;Scheer, Alexander;Missotten, Marc;Ayala, Guidon;Bradshaw, Charles;De Raemy-Schenk, Anne-Marie;Nichols, Anthony;Cirillo, Rocco;Tos, Enrico Gillio;Giachetti, Claudio;Golzio, Lucia;Marinelli, Paolo;Church, Dennis J.;Barberis, Claude;Chollet, Andre;Schwarz, Matthias K.. And the article was included in Journal of Medicinal Chemistry in 2005.Electric Literature of C10H13ClO3S This article mentions the following:

We report a novel chem. class of potent oxytocin receptor antagonists showing a high degree of selectivity against the closely related vasopressin receptors (V1a, V1b, V2). An initial compound, 7, was shown to be active in an animal model of preterm labor when administered by the i.v. but not by the oral route. Stepwise SAR investigations around the different structural elements revealed one position, the arenesulfonyl moiety, to be amenable to structural changes. Consequently, this position was used to introduce a variety of substituents to improve the physicochem. properties. Some of the resulting analogs were found to be superior to 7 both in terms of potency in vitro and aqueous solubility, which translated into significantly improved efficacy in the animal model after i.v. and oral administration. The best compound, 73, potently inhibited oxytocin-induced uterine contractions in nonpregnant rats and reduced spontaneous uterine contractions in late-term pregnant rats. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Electric Literature of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arylsulfonic acid derivatives. XIV. Synthesis and antibacterial activity of new derivatives of 4-alkoxybenzylsulfonamides was written by Grigoryan, L. A.;Kaldrikyan, M. A.;Engoyan, A. P.;Paronikyan, R. V.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1987.Electric Literature of C10H13ClO3S This article mentions the following:

p-ROC₆H₄SO₂Cl (I; R = C₁-C₄ n-alkyl, Me₂CHCH₂) reacted with R¹(CH₂)_nNH₂ (R¹ = Ph, p-MeOC₆H₄; n = 1, 2) in aqueous NaOH to give 15 corresponding p-ROC₆H₄SO₂NH(CH₂)_nR¹ (II) in 55-83% yield. II (same R; R¹ = Ph, n = 1, 2; R = Me, R¹ = p-MeOC₆H₄, n = 1) reacted with addnl. I (same R) or with p-R²C₆H₄CH₂Cl (R² = H, MeO) in dry DMF containing LiH to give 14 corresponding (p-ROC₆H₄SO₂)₂N(CH₂)_nR¹ (III) in 38-61% yield and 31-33% p-MeOC₆H₄CH₂N(CH₂C₆H₄R²–p)SO₂C₆H₄OEt-p (same R²), resp. III had antibacterial activity, but II did not. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Electric Literature of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors was written by Guo, Xiaoke;Yang, Qian;Xu, Jing;Zhang, Li;Chu, Hongxi;Yu, Peng;Zhu, Yingying;Wei, Jinglian;Chen, Weilin;Zhang, Yaozhong;Zhang, Xiaojin;Sun, Haopeng;Tang, Yiqun;You, Qidong. And the article was included in Bioorganic & Medicinal Chemistry in 2013.COA of Formula: C10H13ClO3S This article mentions the following:

Atrial fibrillation (AF) is one of the common arrhythmias that threaten human health. Kv1.5 potassium channel is reported as an efficacious and safe target for the treatment of AF. In this paper, we designed and synthesized three series of compounds through modifying the lead compound RH01617 that was screened out by the pharmacophore model we reported earlier. All of the compounds were evaluated by the whole-patch lamp technol. and most of them possessed potent inhibitory activities against Kv1.5. Two of the compounds were evaluated for the target selectivity as well as the pharmacodynamic effects in an isolated rat model. Due to the promising pharmacol. behavior, one compound deserves further pharmacodynamic and pharmacokinetic evaluations. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3COA of Formula: C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics