Synthetic Route of C21H19ClN2O2On May 23, 2019, Gurney, Mark E.; Nugent, Richard A.; Mo, Xuesheng; Sindac, Janice A.; Hagen, Timothy J.; Fox, David; O’Donnell, James M.; Zhang, Chong; Xu, Ying; Zhang, Han-Ting; Groppi, Vincent E.; Bailie, Marc; White, Ronald E.; Romero, Donna L.; Vellekoop, A. Samuel; Walker, Joel R.; Surman, Matthew D.; Zhu, Lei; Campbell, Robert F. published an article in Journal of Medicinal Chemistry. The article was 《Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders》. The article mentions the following:
Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative anal. of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clin. trials for the treatment of Fragile X Syndrome. After reading the article, we found that the author used 1-(4-((3′-Chloro-6-methoxy-[1,1′-biphenyl]-3-yl)methyl)phenyl)urea(cas: 1155877-97-6Synthetic Route of C21H19ClN2O2)
1-(4-((3′-Chloro-6-methoxy-[1,1′-biphenyl]-3-yl)methyl)phenyl)urea(cas: 1155877-97-6) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Synthetic Route of C21H19ClN2O2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics