Category: 116850-28-3

Molander, Gary A. published the artcileA modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid, Synthetic Route of 116850-28-3, the publication is Tetrahedron (2015), 71(35), 5758-5764, database is CAplus and MEDLINE.

A modified Pd-catalyzed method of forming aryl- and heteroarylboron species and a two-step, one-pot borylation/Suzuki-Miyaura cross coupling using the atom economical tetrahydroxydiboron (bis-boronic acid, BBA) is reported. By using ethylene glycol as an additive, the new method results in increased yields, lower BBA loading, faster reaction times, and a broader reaction scope, including previously problematic substrates such as heterocycles e. g., I.

Tetrahedron published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C7H6ClF, Synthetic Route of 116850-28-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Xi-hua published the artcileQuantitative structure-property relationship of halogenated arenes, Related Products of chlorides-buliding-blocks, the publication is Harbin Gongye Daxue Xuebao (2009), 41(9), 241-245, database is CAplus.

With the define of at. characteristic value δ_i on the mol. topol. theory, the value setting up the group dyeing index ^mX_A and its inverted index ^mX_B, this paper studies relationship between the refractive index and mol. structure of 92 halogenated arenes by using quant. structure-property relationship technol. The reasonable mol. modeling equations were achieved by multiple regression for the prediction of the refractive index of halogenated arenes. The multiple regression equations are established, the correlation coefficient is 0.902 6. The calculated results show that the imputed refractive index of halogenated arenes were in good agreement with the exptl. data, with mean relative deviation being 0.47%. The study showed that application group dyeing index and its inverted index simultaneously can reflect more completely the structure-property relationships of halogenated arenes. The performances of the models were tested through cross-validation by leave-one-out procedure, which shows the estimation stability and prediction of the models based on the group dyeing index are quite contented.

Harbin Gongye Daxue Xuebao published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C7H6ClF, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kanno, Hideo published the artcileSynthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonists, Quality Control of 116850-28-3, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(8), 2049-54, database is CAplus and MEDLINE.

New 1,4-dihydropyridine derivatives I (R = Cl, F, NO₂; R¹, R² = H, Cl, F, NO₂; X = CH₂, CMe₂CH₂), bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethylpropyl ester, were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hypertensive rats. The effects of Ph substituents and ester groups on the antihypertensive activity are discussed. Several compounds showed a more potent antihypertensive activity than nicardipine and most compounds had a longer duration of action. Among them, I (R = F, R¹ = H, R² = NO₂, X = CMe₂CH₂).HCl showed highly potent and long-lasting activity and was selected as a candidate for further pharmacol. investigations.

Chemical & Pharmaceutical Bulletin published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C7H6ClF, Quality Control of 116850-28-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Yang published the artcilePalladium-Catalyzed Carbonylative Synthesis of N-Heterocycles from 1-Chloro-2-fluorobenzenes, Formula: C7H6ClF, the publication is European Journal of Organic Chemistry (2019), 2019(11), 2172-2175, database is CAplus.

A simple and efficient synthesis of pyrido-fused quinazolinones and dibenzoxazepinones by palladium-catalyzed annulation of com. available substituted 1-chloro-2-fluorobenzenes and 2-aminopyridines or 2-aminophenols was developed. The reaction involved carbonylation/aromatic nucleophilic substitution sequential in a one-pot manner.

European Journal of Organic Chemistry published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C24H29N5O3, Formula: C7H6ClF.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Peng published the artcileRadical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination, SDS of cas: 116850-28-3, the publication is Journal of the American Chemical Society (2021), 143(14), 5349-5354, database is CAplus and MEDLINE.

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140°C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chem. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Journal of the American Chemical Society published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C10H15NO, SDS of cas: 116850-28-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volchkov, N. V. published the artcileTwo-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes, Computed Properties of 116850-28-3, the publication is Russian Chemical Bulletin (2020), 69(1), 68-75, database is CAplus.

Gas phase regioselective thermal cycloaddition reactions of chlorotrifluoroethylene with 1,3-butadiene, (E/Z)-1,3-pentadiene, or isoprene in a flow reactor at 440-480°C gave chlorotrifluorocyclohexenes which underwent elimination reactions in aqueous KOH in the presence of benzyltriethylammonium chloride to yield 1,2-difluorobenzene, 2,3-difluorotoluene, and 3,4-difluorotoluene.

Russian Chemical Bulletin published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C8H6ClF3, Computed Properties of 116850-28-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics