Category: 116853-97-5

Luo, Zonghua published the artcileDesign and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands, Application of 2-Chloro-6-methoxyisonicotinoyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 488-496, database is CAplus and MEDLINE.

Eleven new sphingosine 1-phosphate receptor 2 (S1PR2) ligands were synthesized by modifying lead compound N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide (I, JTE-013) and their binding affinities toward S1PRs were determined in vitro using [³²P]S1P and cell membranes expressing recombinant human S1PRs. Among these ligands, 35a (II, IC₅₀ = 29.1 ± 2.6 nM) and 35b (III, IC₅₀ = 56.5 ± 4.0 nM) exhibit binding potency toward S1PR2 comparable to JTE-013 (IC₅₀ = 58.4 ±7.4 nM) with good selectivity for S1PR2 over the other S1PRs (IC₅₀ > 1000 nM). Further optimization of these analogs may identify addnl. and more potent and selective compounds targeting S1PR2.

Bioorganic & Medicinal Chemistry Letters published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Application of 2-Chloro-6-methoxyisonicotinoyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Sung-Chan published the artcileDevelopment of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(53), 6681-6683, database is CAplus and MEDLINE.

The authors report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe, was discovered through a high-content image based screening of 160 members of the chalcone library. The mol. binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.

Chemical Communications (Cambridge, United Kingdom) published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Krishna Kanta published the artcileThe development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells, COA of Formula: C7H5Cl2NO2, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(45), 9336-9338, database is CAplus and MEDLINE.

A low-toxicity nucleus staining fluorescent probe, CDb12, was developed for real time mitosis imaging in live cells. CDb12 was identified by unbiased high-throughput imaging-based screening of a new xanthone library (AX). Unlike the conventional Hoechst dye, the low toxicity of CDb12 allows long term monitoring of cell division over more than one cell cycle.

Chemical Communications (Cambridge, United Kingdom) published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, COA of Formula: C7H5Cl2NO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cockcroft, Xiao-ling published the artcilePhthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase, Synthetic Route of 116853-97-5, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(4), 1040-1044, database is CAplus and MEDLINE.

We have previously described the discovery of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors based on a phthalazinone scaffold. Subsequent optimization of inhibitory activity, metabolic stability and pharmacokinetic parameters has led to a novel series of meta-substituted 4-benzyl-2H-phthalazin-1-one PARP-1 inhibitors which retain low nM cellular activity and show good stability in vivo and efficacy in cell based models.

Bioorganic & Medicinal Chemistry Letters published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 116853-97-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics