Category: 118-69-4

Electric Literature of 118-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118-69-4, name is 2,6-Dichlorotoluene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a round bottom flask was added 100 g of 2,6-dichlorotoluene, 0.5 g antimony trichloride, 59.6 g of chlorine gas was introduced at 25 C under atmospheric pressure, the reaction temperature was controlled at 25 to 30 C, Chlorine speed of 10g / h, After about 6 hours, the reaction of 2,6-dichlorotoluene was terminated by GC, and chlorine was stopped. 124.1 g of a reaction liquid was obtained, which comprised 85.4% of 2,3,6-trichlorotoluene, 1.9% of 2,4,6-trichlorotoluene, 12.7% of tetrachlorotoluene and impurities. The reaction solution was subjected to distillation to obtain 104.7 g of 2,3,6-trichlorotoluene in a yield of 86.3% GC area content of 98%.

The synthetic route of 2,6-Dichlorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Lianhua Technology Co., Ltd.; Lianhua Technology (Yancheng) Co., Ltd.; Fan, Xiaobin; Lin, Xingjun; Xu, Xiaoming; Huang, Chao; Chen, Donghua; Zhou, Shuyong; (8 pag.)CN105601466; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 118-69-4,Some common heterocyclic compound, 118-69-4, name is 2,6-Dichlorotoluene, molecular formula is C7H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ammoxidation runs were carried out in a fixed bed tubular quartz reactor, which is filled with 5g of catalyst particles prepared by the methods described in examples 1 to 3 and mixed with corundum particles of the same size in 1: 1 by weight ratio. A preheating zone is provided on the top of the catalyst bed. The catalyst was activated in a mixture of air and [NH3] at [400C] for 4 hours and then the catalytic runs were performed. The 2,6-DCT and [H20] were pumped in the mole ratio of 1: 15 to 20. The product stream was collected for every half-an-hour and analysed by gas chromatography. The reaction was carried out under the following reaction conditions. A reaction temperature of 350 to [400C] was used, and the GHSV comprised between 650-750 [H-‘.] The contact time consisted of 4.8 to 5.5 seconds. The mole ratio of 2,6-DCT : H20 : NH3: air was 1: 15: 3-4: 21, the molar concentration of 2,6-DCT was 2.4 % and the ratio of O/NH3 was 1. [1 %.]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dichlorotoluene, its application will become more common.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 118-69-4,Some common heterocyclic compound, 118-69-4, name is 2,6-Dichlorotoluene, molecular formula is C7H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5 g of the following catalyst particles, as described in examples 3 and 4, were loaded in the reactor along with the diluent corundum particles (1: 1 by weight) and tested the influence of addition of ethyl bromide (2 % VN) in presence and absence of water vapour. The reaction was performed under the following conditions. A reaction temperature of 350 to [400C] was used. The mole ratio 2,6-DCT : H20 : NH3: air: N2 was 1: 15: 3-4: 21: 0-29. Molar concentration of 2,6-DCT is 1.4 to 3.8 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dichlorotoluene, its application will become more common.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

118-69-4, name is 2,6-Dichlorotoluene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2,6-Dichlorotoluene

5 g of catalyst, as described in examples 3 and 4, was loaded in the reactor along with the diluent corundum particles (1: 1 by weight) and the reaction was performed under the following conditions. A reaction temperature of 350 to [400C] was used, and the GHSV comprised between 650-750 [H-1.] The contact time consisted of 4.8 to 5.5 seconds. The mole ratio of 2,6-DCT : H20 : NH3: air: N2 was 1: 15: 3-4: 21, the molar concentration of 2,6- DCT was 2.4 % and the ratio of [0/NH3] was 1. [1 %.]

The synthetic route of 118-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 118-69-4,Some common heterocyclic compound, 118-69-4, name is 2,6-Dichlorotoluene, molecular formula is C7H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5 g of catalyst, as described in examples 3 and 4, was loaded in the reactor along with the diluent corundum particles (1: 1 by weight) and the reaction was performed under the following conditions. A reaction temperature of 350 to [400C] was used, and the GHSV comprised between 650-750 [H-1.] The contact time consisted of 4.8 to 5.5 seconds. The mole ratio of 2,6-DCT : H20 : NH3: air: N2 was 1: 15: 3-4: 21, the molar concentration of 2,6- DCT was 2.4 % and the ratio of [0/NH3] was 1. [1 %.]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dichlorotoluene, its application will become more common.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118-69-4, name is 2,6-Dichlorotoluene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

(1) In a 1000 ml four-necked flask,300 g of dimethylsulfoxide was added in this order,2,6-dichlorotoluene 100 g (0.62 mol)Heating up,When the temperature reaches 160 C,Dropping 200 gMethanol sodium methoxide solution (sodium methoxide content 28%, 1.04 mol)Methanol was added dropwise,Insulated at 160 C for 8 h.(2)Cooling to 80 ,0.1 g of catalyst PEG-600 (polyethylene glycol 600) was added,At this temperature, 20 g of methyl chloride (0.40 mol) was passed until the mass fraction of 6-chloro-2-hydroxytoluene was less than 1%, and the reaction was carried out for 2 hours.(3) cool to room temperature,And then negative pressure recovery DMSO,After treatment, 96.8 g of 6-chloro-2-methoxytoluene was obtained, the content was 96.0% and the yield was 95.6%.

The synthetic route of 118-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Yangnong Chemical Industry Co., Ltd; Jiangsu Youjia Plant Protection Co., Ltd; Zhou, Qikui; Jiang, Youfa; Zhu, Jianrong; Sun, Bing; Wang, Mingkun; Kuan, Jianbo; Xue, Yadong; (5 pag.)CN106518630; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 118-69-4, name is 2,6-Dichlorotoluene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118-69-4, SDS of cas: 118-69-4

Example 1 3-Chloro-2-methylphenol Process Variant a1 16.1 g (0.1 mol) of 2,6-dichlorotoluene and 19.8 g (0.3 mol) of potassium hydroxide (85%) are heated in 30 ml of diethylene glycol at a bath temperature of 190 C. for 18 hours. The water released by the reaction is distilled off. After cooling, the reaction mixture is stirred with 100 ml of water until a solution is obtained and extracted three times with 50 ml of dichloromethane. The aqueous phase is admixed with 35 ml of 30% hydrochloric acid and extracted three times with 70 ml of dichloromethane. The organic phases are dried over sodium sulphate and concentrated under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (12.4 g, content by HPLC: 83%, 72% of theory). NMR (d6-DMSO): 6.75 (d, 1H, aromatic), 6.85 (d, 1H, aromatic) 7.0 (t, 1H, aromatic), 9.8 (s, 1H, phenolic OH)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Dichlorotoluene, and friends who are interested can also refer to it.

Reference:
Patent; Huebsch, Walter; Lantzsch, Reinhard; Mueh, Thorsten; Weintritt, Holger; US2003/92944; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

118-69-4, Adding a certain compound to certain chemical reactions, such as: 118-69-4, name is 2,6-Dichlorotoluene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118-69-4.

Ammoxidation runs were carried out in a fixed bed tubular quartz reactor, which is filled with 5g of catalyst particles prepared by the methods described in examples 1 to 3 and mixed with corundum particles of the same size in 1: 1 by weight ratio. A preheating zone is provided on the top of the catalyst bed. The catalyst was activated in a mixture of air and [NH3] at [400C] for 4 hours and then the catalytic runs were performed. The 2,6-DCT and [H20] were pumped in the mole ratio of 1: 15 to 20. The product stream was collected for every half-an-hour and analysed by gas chromatography. The reaction was carried out under the following reaction conditions. A reaction temperature of 350 to [400C] was used, and the GHSV comprised between 650-750 [H-‘.] The contact time consisted of 4.8 to 5.5 seconds. The mole ratio of 2,6-DCT : H20 : NH3: air was 1: 15: 3-4: 21, the molar concentration of 2,6-DCT was 2.4 % and the ratio of O/NH3 was 1. [1 %.]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichlorotoluene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TESSENDERLO CHEMIE S.A.; WO2003/101939; (2003); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

118-69-4, The chemical industry reduces the impact on the environment during synthesis 118-69-4, name is 2,6-Dichlorotoluene, I believe this compound will play a more active role in future production and life.

To 400ml of 1-butyl-2,3-dimethylimidazole hexafluorophosphate was added 650g 20%Aqueous solution of sodium methyl mercaptan, heated to a reduced pressure and distilled to 100C/0.08MPa, keeping no distillate flowing out, then suspending heating, adding 200g of 2,6-dichlorotoluene to the system, maintaining at 100C for 3 hours, then cooling to 35 , 30g of methyl chloride gas was introduced into the kettle, kept for 1 hour, and atmospheric distillation was started. After 55 and no distillate flowed out, it was changed to another receiving bottle and vacuum distillation was started. It stopped after 180/0.09MPa heating,A total of 205 g of distillate was received, which was 2-methylthio-6-chlorotoluene with a yield of 97.3%; after the vacuum distillation was completed, the remaining ionic liquid solution was filtered to remove inorganic salts for recovery

The chemical industry reduces the impact on the environment during synthesis 2,6-Dichlorotoluene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shenyang Kechuang Chemicals Co., Ltd.; Lin Yang; Yang Zhaoguo; Li Ziliang; Ming Xu; Li Tao; Zhang Chuanyang; Hu Jinying; (7 pag.)CN111233721; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

118-69-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118-69-4 as follows.

step one:2,6-dichlorotoluene (100 g, 0.62 mol) was added to 1000 ml of dichloromethane at room temperature, and aluminum trichloride (165.6 g, 0.68 mol) was added thereto, and the temperature was controlled below 30 C.Acetyl chloride (97.5 g, 1.24 mol) was added dropwise to the reaction system at a rate of 20 drops per minute.After the completion of the dropwise addition, the temperature was raised to 40 C and refluxed for 12 hours.After the completion of the reaction, the reaction system was cooled to room temperature, and the reaction mixture was poured into 1000 ml of ice water, extracted with dichloromethane (500 ml ¡Á 3), and the organic phase was combined, washed with saturated brine (600 ml ¡Á 2), anhydrous sulfuric acid Magnesium is filtered after drying,The filtrate was concentrated under reduced pressure to give a red brown oil.106 g, crude yield was 84.2%.

According to the analysis of related databases, 118-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANDONG BESTCOMM PHARMACEUTICAL CO LTD; Shandong Bainuo Pharmaceutical Co., Ltd.; YU YANG; Yu Yang; CHEN JINGJIN; Chen Jingjin; ZHOU HUAYIN; Zhou Huayin; WANG LINYONG; Wang Linyong; ZHANG ZHIQIANG; Zhang Zhiqiang; SUN YUANJUN; Sun Yuanjun; QIU XIN; Qiu Xin; WANG YULIANG; Wang Yuliang; (16 pag.)CN108299480; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics