Category: 118754-53-3

Synthetic Route of 118754-53-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118754-53-3 as follows.

Preparation of 2,6-dichloro-4-trifluoromethylbenzaldehyde To a mixture of 65.2 ml of n-butyllithium (1.61M in hexane) and 100 ml of anhydrous ether was added dropwise 29.3 g of 4-bromo-3,5-dichlorobenzotrifluoride (3) in 20 ml of anhydrous ether at -78 C. over a period of 15 minutes, followed by stirring for 20 minutes. Next, 100 ml an anhydrous ether solution of 21.8 ml of N,N-dimethylformamide was added dropwise to the mixture at the same temperature, followed by stirring at -78 C. for 30 minutes and then at 0 C. for 30 minutes. To the reaction mixture was thereafter added 400 ml of aqueous 1N phosphoric acid. The resulting mixture was further stirred for 30 minutes. The reaction mixture was extracted with ether, and the ethereal layers were combined together, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue obtained was distilled under reduced pressure, giving 26.7 g of the desired compound in the form of a colorless oil (yield 78.3%). bp 114-115 C./19 mmHg 1 H-NMR (CDCl3, TMS, delta ppm): 7.65(s, 2H), 10.47(s, 1H)

According to the analysis of related databases, 118754-53-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Otsuka Kagaku Kabushiki Kaisha; US5739083; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 118754-53-3, The chemical industry reduces the impact on the environment during synthesis 118754-53-3, name is 4-Bromo-3,5-dichlorobenzotrifluoride, I believe this compound will play a more active role in future production and life.

Stille Coupling Procedure: 1-Bromo-2,6-dichloro-4-trifluoromethylbenzene(3; 1.205 g, 4.1 mmol) and tributylvinyltin (1.268 g, 4 mmol)were degassed with argon. Toluene (15 mL) was then added, degassed,and stirred. Pd(PPh3)4 (0.173 g, 0.15 mmol) was added and themixture was refluxed for 24 h. The crude product was concentratedby rotary evaporation and purified by silica gel column chromatographywith hexanes to give a colorless oil; yield: 0.562 g (57%).1H NMR (400 MHz, CDCl3): delta = 7.58 (s, 2 H), 6.70 (dd, J = 18, 12 Hz, 1H), 5.86 (dd, J = 17, 1.1 Hz, 2 H), 5.82 (dd, J = 12, 1.1 Hz, 2 H).13C NMR (100 MHz, CDCl3): delta = 138.6, 134.9, 130.6 (q, J = 34 Hz),130.0, 125.3 (q, J = 3.8 Hz), 124.4, 122.6 (q, J = 271 Hz).Anal. Calcd for C9H5Cl2F3: C, 44.85; H, 2.09. Found: C, 45.00; H, 2.25.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3,5-dichlorobenzotrifluoride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Miller, Daniel K.; Bailey, Christopher A.; Sammelson, Robert E.; Synthesis; vol. 47; 18; (2015); p. 2791 – 2798;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 118754-53-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118754-53-3 as follows.

Preparation of 2,6-dichloro-4-trifluoromethylbenzoic acid To a mixture of 65.2 ml of n-butyllithium (1.61M in hexane) and 100 ml of anhydrous ether was added dropwise 29.3 g of 4-bromo-3,5-dichlorobenzotrifluoride (3) in 30 ml of anhydrous ether at -78 C., followed by stirring for 20 minutes. Subsequently, 10 g of dry ice crashed into small pieces was added in small portions to the reaction mixture, followed by stirring at room temperature for 1.5 hours. Ice water was added to the reaction mixture, the mixture was thereafter extracted with ether, and the combined extract was subjected to reverse extraction with 10% aqueous sodium carbonate solution. The aqueous layer was acidified with 6N hydrochloric acid, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gave 20.4 g of the desired product in the form of white crystals (crude yield 79.1%). mp 117~118 C. 1 H-NMR (CDCl3, TMS, delta ppm): 6.21(br, s, 1H), 7.64(s,2H)

According to the analysis of related databases, 118754-53-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Otsuka Kagaku Kabushiki Kaisha; US5739083; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118754-53-3, name is 4-Bromo-3,5-dichlorobenzotrifluoride, A new synthetic method of this compound is introduced below., Recommanded Product: 118754-53-3

To a stirred solution of 2-(4-aminophenyl)-Lambda/-(2-hydroxyethyl)-acetamide (0.100 g, 0.52 mmol), 2,6-dichloro-4-trifluromethylbromobenzene (0.189 g, 0.65mmol), K2CO3 (0.178 g, 1.30 mmol) and xantphos (0.03O g, 0.052 mmol) in 1 ,4-dioxane (2ml) under nitrogen in a microwave tube was added Pd2dba3 (0.024 g, 0.026 mmol) in one portion and the tube sealed. The reaction was heated with stirring in a microwave at 16O0C for 75 minutes. The reaction was cooled before filtering through celite and concentrating in vacuo. The reaction mixture was purified by preparative column chromatography using acidic eluent to afford the named product (38.2 mg). LCMS R,=3.75 min, m/z (ES+) 407 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LECTUS THERAPEUTICS LIMITED; EDWARDS, Simon David; KIMBERLY, Meriel Ruth; ARMER, Richard Edward; KHAN, Nawaz Mohammed; WO2010/10380; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 118754-53-3, name is 4-Bromo-3,5-dichlorobenzotrifluoride, molecular formula is C7H2BrCl2F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 118754-53-3

2.08 g of 2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene (0.01 mol) was added to the reaction flask. 4.9 g of 5-amino-4-((trifluoromethyl)thio)-1H-pyrazole-3-carbonitrile (0.017 mol), 64 mg of copper (10 mol%), 0.27 g 1,10-phenanthroline (15 mol %), dissolved in 15 ml of THF and 5 ml of DMSO, reacted at 60 C for 8 hours. After the reaction is finished, the extract is dried and dried. The crude compound 1 was obtained in a mass of 3.6 g; after the obtained Compound 1 and 20 ml of dichloromethane were uniformly mixed, slowly add 1.7 g of benzoyl peroxide (0.013 mol) at 0 C. After the dropwise addition, the reaction was carried out for 2 hours at room temperature. After the reaction is finished, the extract is dry, purification afforded 3.5 g of fipronil in a yield of 82%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 118754-53-3, its application will become more common.

Reference:
Patent; Jiangsu Changqing Agrochemical Co., Ltd.; Yu Guoquan; Sun Xialin; Ma Changqing; Ding Huaping; (5 pag.)CN109134375; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics