Category: 121-27-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H9Cl2NO

In the reactor was added 800kg 44.45% nitrosyl sulfuric acid solution,Warmed to 25 C,The melted 700kg amino material slowly added to the reactor,The reaction was incubated at 30 ~ 35 2 hours to complete the reaction of the amino compound,

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 121-27-7.

Reference:
Patent; Jiangsu Yi Ke Chemical Co., Ltd.; Yi Jianghua; Xie Shoulei; Yu Qianli; (6 pag.)CN107353185; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 121-27-7, The chemical industry reduces the impact on the environment during synthesis 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, I believe this compound will play a more active role in future production and life.

A solution of 8 (2.56 g, 10.1 mmol), ethyl bromoacetate (7.0 mL, 63 mmol), and N,N-diisopropylethylamine (7.0 mL, 41 mmol) was stirred at 140 C for 5 h. The reaction mixture was cooled down, and diluted with EtOAc (100 mL). The organic layer was washed with 10% aqueous citric acid (100 mL * 2), saturated aqueous NaHCO3, and brine, and dried over MgSO4. The insoluble material was filtered off, and the solution was concentrated under reduced pressure. The residue oil was purified by silica gel column chromatography (hexane/EtOAc = 95:5 to 80:20) to afford 9 (3.68 g, 85%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3): delta (ppm) 1.20 (t, J = 7.2, 6H), 4.10 (s, 4H), 4.11 (q, J = 7.2, 4H), 6.76 (d, J = 8.7, 1H), 6.81-6.87 (m, 4H), 7.24 (d, J = 8.7, 2H). 13C NMR (100 MHz, CDCl3): delta (ppm) 14.15, 54.04, 60.95, 118.72, 119.42, 121.65, 122.31, 127.95, 129.56, 129.94, 142.40, 145.35, 155.99, 170.52. LC-MS (ESI) m/z 426, 428 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-(4-chlorophenoxy)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nakao, Akira; Suzuki, Hiroko; Ueno, Hiroaki; Iwasaki, Hiroshi; Setsuta, Tomofumi; Kashima, Akiko; Sunada, Shinji; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4952 – 4969;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Chloro-2-(4-chlorophenoxy)aniline

In the reactor was added 800kg 44.45% nitrosyl sulfuric acid solution,Warmed to 25 C,The melted 700kg amino material slowly added to the reactor,The reaction was incubated at 30 ~ 35 2 hours to complete the reaction of the amino compound,

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 121-27-7.

Reference:
Patent; Jiangsu Yi Ke Chemical Co., Ltd.; Yi Jianghua; Xie Shoulei; Yu Qianli; (6 pag.)CN107353185; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 121-27-7, These common heterocyclic compound, 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 43.6 g. of isonicotinic acid, 200 ml. of thionyl chloride and 200 ml. of methylene chloride is heated under reflux for 2 hours. The solvent is evaporated, 93.4 g. of 5-chloro-2-(p-chlorophenoxy)aniline, 180.0 g. of anhydrous potassium carbonate and 2800 ml. of benzene are added and the reaction proceeds as described in Example 1. Extraction with petroleum ether gives 5′-chloro-2′-(p-chlorophenoxy)-isonicotinanilide.

The synthetic route of 121-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Cyanamid Company; US4221714; (1980); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121-27-7, Formula: C12H9Cl2NO

EXAMPLE IV-3 STR526 A solution of 27.6 g (0.4 mol) of sodium nitrite in 31.7 ml of water is added dropwise with stirring at 0 C. to 5 C. to 84.3 g (0.3 mol) of 5-chloro-2-(4-chlorophenoxy)aniline (compare, for example, EP No. 34,771), 284 ml of water and 72.2 ml of concentrated hydrochloric acid, the mixture is stirred for a further 15 minutes after completion of the addition and filtered, 16.4 g (0.2 mol) of sodium acetate are added to the filtrate and the solution thus obtainable is added dropwise with stirring at 10 C. to 15 C. to a mixture of 253 ml of water, 123 g (1.5 mol) of sodium acetate, 2.5 g (0.015 mol) of sodium sulphate, 15.9 g (0.1 mol) of copper(II) sulphate and 28.3 g (0.48 mol) of acetaldoxime. After completion of the addition, the mixture is stirred for one hour at room temperature, the pH is then adjusted to 7 by addition of about 40 ml of concentrated hydrochloric acid, 292 ml of concentrated hydrochloric acid are then added in portions and the mixture is heated to reflux temperature for 3 hours. The reaction mixture is subjected to a steam distillation, the oil which separates is taken up in dichloromethane, and the solution is dried over sodium sulphate, concentrated and distilled in a high vacuum. 29.5 g (35% of theory) of 5-chloro-2-(4-chlorophenoxy)acetophenone of boiling point 80-85 C. at 1.5 mbar are obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2-(4-chlorophenoxy)aniline, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Aktiengesellschaft; US4956370; (1990); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics