Category: 1263414-46-5

Lebraud, Honorine published the artcileQuantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe, Name: 4-Chloro-3-fluorostyrene, the publication is Chemical Science (2018), 9(45), 8608-8618, database is CAplus and MEDLINE.

Target engagement is a key concept in drug discovery and its direct measurement can provide a quant. understanding of drug efficacy and/or toxicity. Failure to demonstrate target occupancy in relevant cells and tissues has been recognized as a contributing factor to the low success rate of clin. drug development. Several techniques are emerging to quantify target engagement in cells; however, in situ measurements remain challenging, mainly due to tech. limitations. Here, we report the development of a non-covalent clickable probe, based on SCH772984, a slow off-rate ERK1/2 inhibitor, which enabled efficient pull down of ERK1/2 protein via click reaction with tetrazine tagged agarose beads. This was used in a competition setting to measure relative target occupancy by selected ERK1/2 inhibitors. As a reference we used the cellular thermal shift assay, a label-free biophys. assay relying solely on ligand-induced thermodn. stabilization of proteins. To validate the EC₅₀ values measured by both methods, the results were compared with IC₅₀ data for the phosphorylation of RSK, a downstream substrate of ERK1/2 used as a functional biomarker of ERK1/2 inhibition. We showed that a slow off-rate reversible probe can be used to efficiently pull down cellular proteins, significantly extending the potential of the approach beyond the need for covalent or photoaffinity warheads.

Chemical Science published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Name: 4-Chloro-3-fluorostyrene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jichao published the artcileHexamethyldisilazane Lithium (LiHMDS)-Promoted Hydroboration of Alkynes and Alkenes with Pinacolborane, Application of 4-Chloro-3-fluorostyrene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Lithium-promoted hydroboration of alkynes and alkenes using com. available hexamethyldisilazane lithium as a precatalyst and HBpin as a hydride source has been developed. This method will be appealing for organic synthesis because of its remarkable substrate tolerance and good yields. Mechanistic studies revealed that the hydroboration proceeds through the in situ-formed BH₃ species, which acts to drive the turnover of the hydroboration of alkynes and alkenes.

Journal of Organic Chemistry published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Application of 4-Chloro-3-fluorostyrene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Linghu, Xin published the artcileDevelopment of a Practical Synthesis of ERK Inhibitor GDC-0994, SDS of cas: 1263414-46-5, the publication is Organic Process Research & Development (2017), 21(3), 387-398, database is CAplus.

The process development of a synthetic route to manufacture ERK inhibitor GDC-0994, I, on multikilogram scale is reported herein. The API was prepared as the corresponding benzenesulfonate salt in 7 steps and 41% overall yield. The synthetic route features a biocatalytic asym. ketone reduction, a regioselective pyridone S_N2 reaction, and a safe and scalable tungstate-catalyzed sulfide oxidation The end-game process involves a telescoped S_NAr/desilylation/benzenesulfonate salt formation sequence. Finally, the development of the API crystallization allowed purging of process-related impurities, obtaining >99.5A% HPLC and >99% ee of the target mol.

Organic Process Research & Development published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Rongxiang published the artcileCobalt-catalyzed decarboxylative oxyalkylation of styrenes with α-cyanoacid: Access to γ-ketonitriles, Related Products of chlorides-buliding-blocks, the publication is Tetrahedron Letters (2022), 153807, database is CAplus.

A cobalt-catalyzed decarboxylative oxyalkylation of styrenes ArCH=CH₂ (Ar = 3,4-dimethoxyphenyl, 2-naphthyl, 4-cyanophenyl, etc.) and (E)-prop-1-en-1-ylbenzene with α-cyanoacid has been established, leading to a variety of γ-ketonitriles ArC(O)CH₂CH₂CN and 3-methyl-4-oxo-4-phenylbutanenitrile in moderate yields. An α-Cyanoacid was applied as the nitrile sources. This methodol. was distinguished by operational simplicity, easily available starting materials and good functionality tolerance.

Tetrahedron Letters published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Tengrui published the artcileStereoselective gold(I)-catalyzed vinylcyclopropanation via generation of sulfur-substituted vinyl carbene equivalent, HPLC of Formula: 1263414-46-5, the publication is Angewandte Chemie, International Edition (2021), 60(8), 4070-4074, database is CAplus and MEDLINE.

A stereoselective gold(I)-catalyzed vinylcyclopropanation of alkenes has been developed. A gold-coordinated cationic vinyl carbene species, readily generated via a rearrangement of the ethylenedithioacetal of propargyl aldehyde, reacts with a wide range of alkenes to afford thio-substituted vinylcyclopropanes. The gold-catalyzed vinyl cyclopropanation proceeds under mild conditions at room temperature and is generally selective for the formation of cis-substituted cyclopropanes. The reaction allows the formal introduction of a “naked” vinyl carbene, by subsequent chemoselective hydrodesulfuration of the ethylenedithio-bridge. The synthetic utility of the new method is demonstrated by a short, racemic formal synthesis of the alkaloid cephalotaxin, hinging on a key vinyl cyclopropane-cyclopentene rearrangement.

Angewandte Chemie, International Edition published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C19H34ClN, HPLC of Formula: 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ren, Li published the artcileDiscovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2, Application In Synthesis of 1263414-46-5, the publication is Journal of Medicinal Chemistry (2015), 58(4), 1976-1991, database is CAplus and MEDLINE.

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of I, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, I was selected for further preclin. evaluation.

Journal of Medicinal Chemistry published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Application In Synthesis of 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qian, Bo published the artcileIron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids, SDS of cas: 1263414-46-5, the publication is Journal of the American Chemical Society (2017), 139(37), 13076-13082, database is CAplus and MEDLINE.

Intermol. carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective carboamination of acyclic olefins represents an addnl. challenge in intermol. carboaminations. We have developed a general alkylamination of vinylarenes and the unprecedented diastereoselective anti-carboamination of unsaturated esters, generating amines and unnatural β-amino acids. This alkylamination is enabled by difunctional alkylating reagents and the iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as both alkylating reagents and internal oxidizing agents. A computational study suggests that addition of a nitrile to the carbocation is the diastereoselectivity-determining step, and hyperconjugation is proposed to account for the highly diastereoselective anti-carboamination.

Journal of the American Chemical Society published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics