Category: 128-09-6

Rogers, David A.; Gallegos, Jillian M.; Hopkins, Megan D.; Lignieres, Austin A.; Pitzel, Amy K.; Lamar, Angus A. published the artcile< Visible-light photocatalytic activation of N-chlorosuccinimide by organic dyes for the chlorination of arenes and heteroarenes>, SDS of cas: 128-09-6, the main research area is arene chlorosuccinimide methylene green catalyst photochem chlorination.

A variety of arenes and heteroarenes are chlorinated in moderate to excellent yields using N-chlorosuccinimide (NCS) under visible-light activated conditions. A screening of known organic dye photocatalysts resulted in the identification of methylene green as the most efficient catalyst to use with NCS. According to mechanistic studies described within, the reaction was speculated to proceed via a single electron oxidation of NCS utilizing methylene green under visible-light photoredox pathway. The photo-oxidation of NCS amplifies the electrophilicity of the chlorine atom of the NCS, thus led to enhanced reactivity as a chlorinating reagent with aromatic substrates.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Zi-Hao; Fiser, Bela; Jiang, Biao-Lin; Li, Jian-Wei; Xu, Bao-Hua; Zhang, Suo-Jiang published the artcile< N-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N-chlorosuccinimide>, COA of Formula: C4H4ClNO2, the main research area is hydroxyphthalimide benzoquinone catalyzed chlorination benzylic bond chlorosuccinimide.

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with com. available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theor. anal. indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.

Organic & Biomolecular Chemistry published new progress about C-H bond (hydrocarbon). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hou, Jiahao; Wang, Kai; Zhang, Changjun; Wei, Tingting; Bai, Renren; Xie, Yuanyuan published the artcile< Metal-Free Electrochemical Oxidative Dihalogenation of Quinolines on the C5 and C7 Positions Using N-Halosuccinimides>, Category: chlorides-buliding-blocks, the main research area is electrochem oxidative dihalogenation quinoline halosuccinimide.

An efficient and convenient method for electrochem. oxidative dichlorination or dibromination of 8-aminoquinolines on C5 and C7 positions using N-halosuccinimides (NCS and NBS) as the halogen source was described. Substrates with various functional groups were transformed smoothly and the halogenated products were obtained in good to excellent yields. These transformations feature transition-metal-free, oxidant-free, and short reaction time.

European Journal of Organic Chemistry published new progress about Electrochemical redox reaction. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nishii, Yuji; Ikeda, Mitsuhiro; Hayashi, Yoshihiro; Kawauchi, Susumu; Miura, Masahiro published the artcile< Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides>, COA of Formula: C4H4ClNO2, the main research area is arene triptycenyl sulfide catalyst electrophilic aromatic halogenation halosuccinimide regioselective; aryl halide preparation.

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray anal. A preliminary computational study disclosed that the π system of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

Journal of the American Chemical Society published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Mu-Yi; Pannecoucke, Xavier; Jubault, Philippe; Besset, Tatiana published the artcile< Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature>, Computed Properties of 128-09-6, the main research area is palladium catalyzed stereoselective chlorination acrylamide.

In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds

Organic Letters published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Computed Properties of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Priya, V.; Subalakshmi, M. published the artcile< Study of oxidation of dyes by N-chlorosuccinimide in aqueous acetic acid medium: A kinetic and mechanistic>, SDS of cas: 128-09-6, the main research area is dye chlorosuccinimide acetic acid medium oxidation kinetic.

Kinetics of oxidation of Dyes by N-Chlorosuccinamide(NCS) in acetic acid medium has been done in the presence of hydrochloric acid. The reaction follows first order kinetics with respect to both [NCS], [Substrate] and [HCl]. Increases in ionic strength increases the rate and addition of the reaction product succinamide has a slight retarding effect on the reaction rate. Increase in the dielec. constant of the medium decreases the rate. Activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperature [40-55 oC] and oxidation products are identified. A most probable reaction mechanism is proposed and an appropriate rate law is deduced to account for the observed kinetic data.

International Journal of Chemical Studies published new progress about Activation energy. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ivanova, Yu. B.; Chizhova, N. V.; Khrushkova, Yu. V.; Rusanov, A. I.; Mamardashvili, N. Zh. published the artcile< Synthesis, Spectral, and Coordination Properties of Halogen-Substituted Tetraarylporphyrins>, Application In Synthesis of 128-09-6, the main research area is chloro bromo tetraarylporphyrin cobalt preparation spectrum coordination kinetics acidity.

2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetra(4-chlorophenyl)porphyrin and 2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetra(4-bromophenyl)porphyrin were synthesized. The obtained compounds were identified by electronic absorption and 1H NMR spectroscopy as well as mass spectrometry. The complex-forming properties of the synthesized porphyrins in the Zn acetate(II)-MeCN system at 278-298 K were studied. Kinetic parameters of the formation of the corresponding Zn complexes in MeCN were determined

Russian Journal of General Chemistry published new progress about Acidity. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kesavan, Arunachalam; Anbarasan, Pazhamalai published the artcile< Catalytic enantioselective oxysulfenylation of o-vinylanilides>, Electric Literature of 128-09-6, the main research area is thio tethered benzoxazine preparation; vinylanilide imide catalytic enantioselective oxysulfenylation.

Tf2NH-Assisted BINAM-derived thiophosphoramide catalysis was accomplished for the enantioselective oxysulfenylation of o-vinylanilides with N-(aryl/alkylthio)imides. The developed reaction offered access to diverse substituted aryl/alkylthio tethered 3,1-benzoxazines I [R = 6-MeO, 6-Cl, 7-Cl, 8-MeO, 8-BzO; R1 = Ph, 4-EtC6H4, 4-FC6H4, etc.; Ar = Ph, Bn, 2-MeC6H4, etc.; Ar1 = Ph, 4-MeC6H4, 3-IC6H4, etc.] in excellent yields and enantiomeric ratios. Furthermore, synthetic applications of benzoxazines and aryl/alkylthio moieties and a transition state model for the observed enantioselectivity were also discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-vinylanilides). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Electric Literature of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takashima, Hiroki; Koga, Yoshikatsu; Manabe, Shino; Ohnuki, Kazunobu; Tsumura, Ryo; Anzai, Takahiro; Iwata, Nozomi; Wang, Yang; Yokokita, Takuya; Komori, Yukiko; Mori, Daiki; Usuda, Sachiko; Haba, Hiromitsu; Fujii, Hirofumi; Matsumura, Yasuhiro; Yasunaga, Masahiro published the artcile< Radioimmunotherapy with an 211At-labeled anti-tissue factor antibody protected by sodium ascorbate>, Application of C4H4ClNO2, the main research area is astatine labeled anti tissue factor antibody sodium ascorbate radioimmunotherapy; antibody denaturation; astatine-211; radioimmunotherapy; sodium ascorbate; tissue factor.

Tissue factor (TF), the trigger protein of the extrinsic blood coagulation cascade, is abundantly expressed in various cancers including gastric cancer. Anti-TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody-drug conjugates (ADCs) and mol. imaging probes. We prepared an anti-TF mAb, clone 1084, labeled with astatine-211 (211At), as a promising alpha emitter for cancer treatment. Alpha particles are characterized by high linear energy transfer and a range of 50-100 μm in tissue. Therefore, selective and efficient tumor accumulation of alpha emitters results in potent antitumor activities against cancer cells with minor effects on normal cells adjacent to the tumor. Although the 211At-conjugated clone 1084 (211At-anti-TF mAb) was disrupted by an 211At-induced radiochem. reaction, we demonstrated that astatinated anti-TF mAbs eluted in 0.6% or 1.2% sodium ascorbate (SA) solution were protected from antibody denaturation, which contributed to the maintenance of cellular binding activities and cytocidal effects of this immunoconjugate. Although body weight loss was observed in mice administered a 1.2% SA solution, the loss was transient and the radioprotectant seemed to be tolerable in vivo. In a high TF-expressing gastric cancer xenograft model, 211At-anti-TF mAb in 1.2% SA exerted a significantly greater antitumor effect than nonprotected 211At-anti-TF mAb. Moreover, the antitumor activities of the protected immunoconjugate in gastric cancer xenograft models were dependent on the level of TF in cancer cells. These findings suggest the clin. availability of the radioprotectant and applicability of clone 1084 to 211At-radioimmunotherapy.

Cancer Science published new progress about Antitumor agents. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chekan, Jonathan R.; Lee, Ga Young; El Gamal, Abrahim; Purdy, Trevor N.; Houk, K. N.; Moore, Bradley S. published the artcile< Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase>, Formula: C4H4ClNO2, the main research area is crystal structure tetrabromopyrrole debrominase dehalogenation thyroid deiodinase.

Enzymic dehalogenation is an important and well-studied biol. process in both the detoxification and catabolism of small mols., many of which are anthropogenic in origin. However, dedicated dehalogenation reactions that replace a halogen atom with a hydrogen are rare in the biosynthesis of natural products. In fact, the debrominase Bmp8 is the only known example. It catalyzes the reductive debromination of the coral settlement cue and the potential human toxin 2,3,4,5-tetrabromopyrrole as part of the biosynthesis of the antibiotic pentabromopseudilin. Using a combination of protein crystallog., mutagenesis, and computational modeling, we propose a catalytic mechanism for Bmp8 that is reminiscent of that catalyzed by human deiodinases in the maintenance of thyroid hormones. The identification of the key catalytic residues enabled us to recognize divergent functional homologs of Bmp8. Characterization of one of these homologs demonstrated its debromination activity even though it is found in a completely distinct genomic context. This observation suggests that addnl. enzymes outside those associated with the tetrabromopyrrole biosynthetic pathway may be able to alter the lifetime of this compound in the environment.

Biochemistry published new progress about Crystal structure. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics