Category: 128-09-6

Zhang, Yuanyuan; Liang, Yaoyu; Zhao, Xiaodan published the artcile< Chiral Selenide-Catalyzed, Highly Regio- and Enantioselective Intermolecular Thioarylation of Alkenes with Phenols>, Related Products of 128-09-6, the main research area is chiral phenol preparation regioselective enantioselective diastereoselective; alkene phenol thiosuccinimide three component thioarylation chiral selenide catalyst.

Enantioselective electrophilic three-component thioarylation of alkenes by chiral selenide catalysis with free phenols as arylating sources is disclosed. A variety of chiral phenols, e.g., I, were prepared in high regio-, enantio-, and diastereoselectivities. Mechanistic studies revealed that this transformation went through carbon nucleophilic attack to give the products rather than the process of intramol. rearrangement of phenolic ether intermediates. The application of this organocatalytic method in the alkylation of methoxy-substituted benzenes elucidated its generality.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Related Products of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Zheng-Wang; Zhu, Hui; Grimme, Stefan published the artcile< Mechanistic Insights for Aniline-Catalyzed Halogenation Reactions>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is anisole halosuccinimide aniline catalyst halogenation reaction mechanism.

Lewis base catalyzed electrophilic aromatic halogenation using N-halosuccinimides (NsX; X=Cl, Br, I) under mild conditions has attracted much attention, but the detailed mechanism remains elusive. Using the aniline MesNH2 and anisole PhOMe as the typical base catalyst and aromatic substrate, resp., a novel mechanism is revealed by extensive DFT calculations The autogenic protonation of imine XMes=NH (via Mes=NH+ mediated dimerization of MesNH2) is crucial to initialize the electrophilic halonium X+ transfer to nucleophilic substrates. It is shown that the aniline MesNH2 and more basic imine XMes=NH may act as efficient halonium X+ and proton H+ shuttles, resp., connected by the arenium XMesNH2+. Non-coordinating MesNH3+ salts are suggested as efficient catalyst for electrophilic iodination. Without suitable stabilization of the highly basic anion Ns-, the generally accepted concept of Lewis base catalyst as simple X+ shuttle will never work efficiently due to a high thermodn. barrier. In general, autogenic or addnl. acid additives should be used for more efficient Lewis base catalyzed halogenation.

ChemCatChem published new progress about Free energy. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Jia; Li, Yu-An; Wu, Ge; Zhang, Xu published the artcile< Metal-free aminohalogenation of quinones with alkylamines and NXS at room temperature>, Category: chlorides-buliding-blocks, the main research area is halo amino naphthalenedione preparation; naphthoquinone amine aminohalogenation; NXS; aminohalogenation; metal-free; quinones; radical reactions.

A simple and practical strategy for intermol. aminohalogenation of quinone with alkyl amines and NXS was developed for preparation of halo(amino)naphthalenediones I [X = H, Cl, Br, I; R1 = Me; R2 = 2-cyanoethyl, (4-bromophenyl)methyl, phenethyl, (3S)-3-(2-methylphenoxy)-3-phenyl-propyl; R1 = R2 = (CH2)2O(CH2)2, (CH2)2CH(OH)(CH2)2, (CH2)2CH(CO2Me)(CH2)2], in which haloamines generated in situ were employed as bifunctional reagents. The reaction system was reliable, efficient and wide in substrate range, which was suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Halogenation (amino). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bera, Shyamal Kanti; Mal, Prasenjit published the artcile< Mechanochemical-Cascaded C-N Cross-Coupling and Halogenation Using N-Bromo- and N-Chlorosuccinimide as Bifunctional Reagents>, Category: chlorides-buliding-blocks, the main research area is phenanthridinone derivative preparation crystal structure mol; biphenyl carboxamide halosuccinimide cascade cross coupling halogenation.

Direct synthesis of halo-substituted phenanthridinone derivatives I [R = Cl, Br, I; R1 = H, 3-Me, 3-F, etc.; R2 = H, 8-Me; R3 = OMe, Ph] was achieved via cascade C-N bond formation and subsequent halogenation reactions of N-halosuccinimides with N-methoxy-[1,1′-biphenyl]-2-carboxamides. During the reactions, NBS/NCS first assisted the oxidative C-N coupling reaction and subsequently promoted a halogenation reaction. Thus, the role of NBS/NCS was established to be bifunctional. This protocol offered a mild, solvent-free, convenient, one-pot synthesis of compounds I.

Journal of Organic Chemistry published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pourmazaheri, Helen; Soorni, Aboozar; Kohnerouz, Bahram Baghban; Dehaghi, Nafiseh Khosravi; Kalantar, Enayatollah; Omidi, Mansoor; Naghavi, Mohammad Reza published the artcile< Comparative analysis of the root and leaf transcriptomes in Chelidonium majus L.>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is Chelidonium benzylisoquinoline alkaloid transcriptome gene ontol functional annotation.

Chelidonium majus is a traditional medicinal plant, which commonly known as a rich resource for the major benzylisoquinoline alkaloids (BIAs), including morphine, sanguinarine, and berberine. To understand the biosynthesis of C. majus BIAs, we performed de novo transcriptome sequencing of its leaf and root tissues using Illumina technol. Following comprehensive evaluation of de novo transcriptome assemblies produced with five programs including Trinity, Bridger, BinPacker, IDBA-tran, and Velvet/Oases using a series of k-mer sizes (from 25 to 91), BinPacker was found to produce the best assembly using a k-mer of 25. This study reports the results of differential gene expression (DGE), functional annotation, gene ontol. (GO) anal., classification of transcription factor (TF)s, and SSR and miRNA discovery. Our DGE anal. identified 6,028 transcripts that were up-regulated in the leaf, and 4,722 transcripts that were up-regulated in the root. Further investigations showed that most of the genes involved in the BIA biosynthetic pathway are significantly expressed in the root compared to the leaf. GO anal. showed that the predominant GO domain is “”cellular component””, while TF anal. found bHLH to be the most highly represented TF family. Our study further identified 10 SSRs, out of a total of 39,841, that showed linkage to five unigenes encoding enzymes in the BIA pathway, and 10 conserved miRNAs that were previously not detected in this plant. The comprehensive transcriptome information presented herein provides a foundation for further explorations on study of the mol. mechanisms of BIA synthesis in C. majus.

PLoS One published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Andronati, Serhiy A.; Pavlovsky, Viktor I.; Golovenko, Mykola Ya.; Reder, Anatoliy S.; Larionov, Vitalii B.; Valivodz’., Irina P. published the artcile< Synthesis and extraction efficiency from biological fluids of [214C]Propoxazepam: a potent analgesic with multifunctional mechanism of action>, HPLC of Formula: 128-09-6, the main research area is synthesis extraction biol fluid propoxazepam analgesic pharmacokinetic study.

A method has been developed for the synthesis of isotopically labeled 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin- 2(3H)-one (Propoxazepam) in a six-step synthesis starting from [1 14C]Glycine with the 30% yield. [214C]Propoxazepam was isolated with a specific activity of 2,68 μ Ci/mol, a chem. purity of 99.0%, and a radiochem. purity of 89.8%. In the model experiments there were rationed the quantity of sequential extractions and extragents volumes ratio to provide 90%, 95% or 99% of significance level extraction The estimated anal. characteristics of the method (coefficient of variation ωs = 3,33%, relative error ε = 9,53%) make it possible for use in pharmacokinetic studies in animals.

Journal of Chemical, Biological and Physical Sciences published new progress about Analgesics. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stafford, Alex; Ahn, Dowon; Raulerson, Emily K.; Chung, Kun-You; Sun, Kaihong; Cadena, Danielle M.; Forrister, Elena M.; Yost, Shane R.; Roberts, Sean T.; Page, Zachariah A. published the artcile< Catalyst Halogenation Enables Rapid and Efficient Polymerizations with Visible to Far-Red Light>, Formula: C4H4ClNO2, the main research area is catalyst halogenation rapid polymerization visible Far Red light; high resolution visible light 3D printing.

The driving of rapid polymerizations with visible to near-IR light will enable nascent technologies in the emerging fields of bio- and composite-printing. However, current photopolymerization strategies are limited by long reaction times, high light intensities, and/or large catalyst loadings. The improvement of efficiency remains elusive without a comprehensive, mechanistic evaluation of photocatalysis to better understand how composition relates to polymerization metrics. With this objective in mind, a series of methine- and aza-bridged boron dipyrromethene (BODIPY) derivatives were synthesized and systematically characterized to elucidate key structure-property relationships that facilitate efficient photopolymerization driven by visible to far-red light. For both BODIPY scaffolds, halogenation was shown as a general method to increase polymerization rate, quant. characterized using a custom real-time IR spectroscopy setup. Furthermore, a combination of steady-state emission quenching experiments, electronic structure calculations, and ultrafast transient absorption revealed that efficient intersystem crossing to the lowest excited triplet state upon halogenation was a key mechanistic step to achieving rapid photopolymerization reactions. Unprecedented polymerization rates were achieved with extremely low light intensities (<1 mW/cm2) and catalyst loadings (<50 μM), exemplified by reaction completion within 60 s of irradiation using green, red, and far-red light-emitting diodes. Halogenated BODIPY photoredox catalysts were addnl. employed to produce complex 3D structures using high-resolution visible light 3D printing, demonstrating the broad utility of these catalysts in additive manufacturing Journal of the American Chemical Society published new progress about Attenuated-total-reflectance IR spectroscopy. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reddy, Raju Jannapu; Kumar, Jangam Jagadesh; Kumari, Arram Haritha published the artcile< Unprecedented Reactivity of β-Iodovinyl Sulfones: An Efficient Synthesis of β-Keto Sulfones and β-Keto Thiosulfones>, Synthetic Route of 128-09-6, the main research area is iodovinyl sulfone oxidation sulfenylation sodium acetate; keto sulfone preparation; beta keto thiosulfone preparation.

An unprecedented reactivity of (E)-β-iodovinyl sulfones in the presence of NaOAc is reported. The (E)-β-iodovinyl sulfones were treated with NaOAc in DMSO/H2O to yield β-keto sulfones in moderate to high yields. A novel oxidative difunctionalization of β-iodovinyl sulfones with thiosulfonates and NaOAc in DMF has been developed. This metal-free oxosulfenylation is an operationally simple to access a wide range of β-keto thiosulfones (α-thioaryl-β-keto sulfones) in moderate to high yields. The transformations were reliable at gram-scale, thus illustrating its efficiency and practicality. A plausible mechanism for the protocol is also proposed.

European Journal of Organic Chemistry published new progress about Ketones, sulfones Role: SPN (Synthetic Preparation), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Synthetic Route of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L. published the artcile< Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst>, Application In Synthesis of 128-09-6, the main research area is regioselective electrophilic chlorination phenol aniline Lewis basic selenoether catalyst.

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chem. to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approx. 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cai, Huan; Jiang, Yu; Zhang, Sheng; Cai, Ning-Ning; Zhu, Wen-Qian; Yang, Rui; Tang, Bo; Li, Zi-Yi; Zhang, Xue-Ming published the artcile< Culture bovine prospermatogonia with 2i medium>, Application of C4H4ClNO2, the main research area is culture bovine prospermatogonia 2i medium; cattle; cell culture; histone modification; prospermatogonia; testis.

Germplasm cryopreservation and expansion of gonocytes/prospermatogonia or spermatogonial stem cells (SSCs) are important; however, it’s difficult in cattle. Since inhibitors of Mek1/2 and Gsk3β (2i) can enhance pluripotency maintenance, effects of 2i-based medium on the cultivation of bovine prospermatogonia from the cryopreserved tissues were examined The testicular tissues of newborn bulls were well cryopreserved. High mRNA levels of prospermatogonium/SSC markers (PLZF, GFRα-1) and pluripotency markers (Oct4/Pouf5, Sox2, Nanog) were detected and the PLZF+/GFRα-1+ prospermatogonia were consistently identified immunohistochem. in the seminiferous cords. Using differential plating and Percoll-based centrifugation, 41.59% prospermatogonia were enriched and they proliferated robustly in 2i medium. The 2i medium boosted mRNA abundances of Pouf5, Sox2, Nanog, GFRα-1, PLZF, anti-apoptosis gene Bcl2, LIF receptor gene LIFR and enhanced PLZF protein expression, but suppressed mRNA expressions of spermatogonial differentiation marker c-kit and pro-apoptotic gene Bax, in the cultured prospermatogonia. It also alleviated H2O2-induced apoptosis of the enriched cells and decreased histone H3 lysine (K9) trimethylation (H3K9me3) and its methylase Suv39h1/2 mRNA level in the cultured seminiferous cords. Overall, 2i medium improves the cultivation of bovine prospermatogonia isolated from the cryopreserved testes, by inhibiting Suv39h1/2-mediated H3K9me3 through Mek1/2 and Gsk3β signalling, evidencing successful cryopreservation and expansion of bovine germplasm.

Andrologia published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Bax). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics