Category: 128-09-6

Ivanova, Yu. B.; Chizhova, N. V.; Shumilova, I. A.; Rusanov, A. I.; Mamardashvili, N. Zh. published the artcile< Acid-Base Properties of Polyhalogenated Tetraphenylporphyrins>, Application of C4H4ClNO2, the main research area is zinc Octabromotetrakisdichlorophenylporphyrinato Octachlorootetrakisdichlorophenylporphyrinato complex preparation; Octabromotetrakisdichlorophenylporphyrin Octachlorootetrakisdichlorophenylporphyrin tetrakisdichlorophenylporphyrin preparation acidity basicity constant.

[2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) and [2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) were synthesized by halogenation of [5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]zinc(II) with N-bromosuccinimide and N-chlorosuccinimide, resp., in a mixture of chloroform with methanol. Treatment of the halogenated zinc porphyrins with trifluoroacetic acid in chloroform gave the corresponding free ligands. The isolated compounds were identified by electronic absorption, 1H NMR, and mass spectra. The acid-base properties of 5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin, 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin, and 2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin were studied in acetonitrile at 298 K. Their acidity and basicity constants and concentration ranges of their ionized forms were determined

Russian Journal of Organic Chemistry published new progress about Acid-base equilibrium. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tian, Zhenhao; Ding, Lele; Li, Kun; Song, Yunqing; Dou, Tongyi; Hou, Jie; Tian, Xiangge; Feng, Lei; Ge, Guangbo; Cui, Jingnan published the artcile< Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems>, Category: chlorides-buliding-blocks, the main research area is design long wavelength fluorescence sensing carboxylesterase 1.

Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally designed using meso-carboxyl-BODIPY as the basic fluorophore based on the substrate preference and catalytic properties of CES1. Following mol. docking-based virtual screening combined with reaction phenotyping-based exptl. screening, we found that MMB (probe 7) exhibited the optimal combination of sensitivity and specificity toward human CES1 in contrast to other ester derivatives Under physiol. conditions, MMB could be readily hydrolyzed by CES1 and release MCB; such biotransformation brought great changes in the electronic properties at the meso position of the fluorophore and triggered a dramatic increase in fluorescence emission around 595 nm. Moreover, MMB was cell membrane permeable and was successfully applied to monitor the real activities of CES1 in various biol. samples including living cells, tissue slices, organs, and zebrafish. In summary, this study showed a good example for constructing specific fluorescent probe(s) for a target enzyme and also provided a practical and sensitive tool for real-time sensing of CES1 activities in complicated biol. samples. All these findings would strongly facilitate high-throughput screening of CES1 modulators and the studies on CES1-associated physiol. and pathol. processes.

Analytical Chemistry (Washington, DC, United States) published new progress about Danio rerio. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Losev, Vladimir N.; Parfenova, Victoriya V.; Elsuf’ev, Evgeney V.; Borodina, Elena V.; Metelitsa, Segey I.; Trofimchuk, Anatoliy K. published the artcile< Separation and preconcentration followed by ICP-OES and ICP-MS determination of precious metals using silica gel chemically modified with dithiocarbamate groups>, SDS of cas: 128-09-6, the main research area is metal silica gel dithiocarbamate separation preconcentration ICPOES ICPMS.

Silica gel chem. modified with dithiocarbamate groups (DTCS) was used for separation and preconcentration of precious metals and their subsequent determination in geol. samples and their processing products by inductively coupled plasma optical emission spectrometry and inductively coupled plasma mass spectrometry. DTCS was characterized by TGA/DSC, FT-IR, and CHNS-anal. DTCS quant. extracted Au3+, Pd2+, Pt2+, Pt4+ at 20°C from 0.5 to 4.0 M HCl media and Rh3+, Ir4+, Ru4+, and Os4+ at 95°C in the presence of 0.025 M SnCl2. Two-column procedure was proposed to sep. precious metals from matrix components and to sep. kinetically inert precious metals from kinetically labile ones.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Adsorbents. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Barlaam, Bernard; Boiko, Scott; Boyd, Scott; Dry, Hannah; Gingipalli, Lakshmaiah; Ikeda, Timothy; Johnson, Tony; Kawatkar, Sameer; Lorthioir, Olivier; Pike, Andy; Pollard, Hannah; Read, Jon; Su, Qibin; Wang, Haiyun; Wang, Huimin; Wang, Lianghe; Wang, Peng; Edmondson, Scott D. published the artcile< Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is preparation pyrazolyl pyrimidine derivative structure SYK inhibitor; Diamine; Kinase selectivity; SYK.

Hybridization of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimization of a novel pyrimidine-based series of potent and selective SYK inhibitors, where the original aminomethylene group was replaced by a 3,4-diaminotetrahydropyran group. The initial compound 5 achieved excellent SYK potency. However, it suffered from poor permeability and modest kinase selectivity. Further modifications of the 3,4-diaminotetrahydropyran group were identified and the interactions of those groups with Asp512 were characterised by protein X-ray crystallog. Further optimization of this series saw mixed results where permeability and kinase selectivity were increased and oral bioavailability was achieved in the series, but at the expense of potent hERG inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents (potential as). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Riddell, Adam B.; Michalski, Michelle M.; Snowdon, Monika R.; Hirst, Mark J.; Schwan, Adrian L. published the artcile< N-Sulfanylimides as the Sulfur Source for Alkyl Allenyl Sulfoxides via [2,3]-Sigmatropic Rearrangement>, Synthetic Route of 128-09-6, the main research area is propargyl alc sulfanylsuccinimide sigmatropic rearrangement; alkyl allenyl sulfoxide preparation.

In this paper, N-sulfanylsuccinimides (thiosuccinimides) were shown to be a viable replacement for sulfenyl chlorides. A number of allenyl alkyl sulfoxides were prepared in fair to good yields (21-73%, 21 examples). In addition, some butyn-1,4-diols could be selectively monofunctionalized to form allenyl sulfoxides (26-71%) with a hydroxyalkyl group geminal to the sulfur. Butynediols also permitted synthetic access to dienes via successive sulfenate ester formation and [2,3]-sigmatropic rearrangement reactions. N-2-Trimethylsilylethylthosucinimides were among the highest yielding of the thioimides.

ChemistrySelect published new progress about [2,3]-Sigmatropic rearrangement. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Synthetic Route of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yun-Feng; Wei, Ya-Feng; Tian, Jun; Zhang, Juan; Chang, Hong-Hong; Gao, Wen-Chao published the artcile< N-Thiohydroxy Succinimide Esters (NTSEs): Versatile Reagents for Selective Acyl and Acylthio Transfer>, HPLC of Formula: 128-09-6, the main research area is thiohydroxy succinimide ester preparation regioselective acyl transfer reaction.

Differentiation between similarly reactive sites in mols. represents an ongoing challenge of organic synthesis. Herein we described one kind of versatile reagents, N-thiohydroxy succinimide esters (NTSEs), serving as both acyl and acylthio surrogates for the diverse synthesis of ketones, thioesters, amides, and acyl disulfides by selective cleavage of similarly reactive C-S and N-S bonds.

Organic Letters published new progress about Amides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kubota, Chihiro; Morita, Daisuke; Fujita, Keisuke; Yamamoto, Sonoka; Suzuki, Toyoko; Okano, Kentaro; Funahashi, Masahiro; Horie, Masaki; Mori, Atsunori published the artcile< Thermally-induced doping of the regioregular polythiophene bearing alkylene spacered benzene-sulfonate group at the side chain>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is regioregular polythiophene alkylene spacered benzene sulfonate conductivity.

Regioregular polythiophene bearing a benzenesulfonate group, which involved an alkylene spacer between thiophene and benzene ring, was synthesized. The obtained polythiophene was shown to improve its conductivity by heating the polymer thin film through the transformation of the ester group into the corresponding sulfonic acid.

Heterocycles published new progress about Electric current-potential relationship. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumari, Arram Haritha; Kumar, Jangam Jagadesh; Krishna, Gamidi Rama; Reddy, Raju Jannapu published the artcile< Nickel-Catalyzed Difunctionalization of Alkynyl Bromides with Thiosulfonates and N -Arylthio Succinimides: A Convenient Synthesis of 1,2-Thiosulfonylethenes and 1,1-Dithioethenes>, COA of Formula: C4H4ClNO2, the main research area is alkynyl bromide arylthiosulfonate nickel catalyst regioselective diastereoselective thiosulfonylation; thiosulfonylethene preparation; arylthio succinamide alkynyl bromide nickel catalyst regioselective diastereoselective dithiolation; dithioethene preparation.

An efficient nickel-catalyzed vicinal thiosulfonylation of 1-bromoalkynes with thiosulfonates in the presence of cesium carbonate was described. An operationally simple and highly regioselective atom transfer radical addition (ATRA) of alkynyl bromides provides a wide range of ( E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields. The extensive substrate scope of both alkynyl bromides and thiosulfonates was explored with a broad range of functional groups. Indole-derived 1,1-bromoalkenes were also successfully explored in this 1,2-thiosulfonylation process. Moreover, the nickel-catalyzed geminal-dithiolation of alkynyl bromides with N-arylthio succinimides provides 1,1-dithioalkenes in high yields. The present protocol was reliable on gram scale, and a sequential one-pot bromination and thiosulfonylation of phenylacetylene is achieved in a scale-up synthesis. Following control experiments, a plausible mechanism was proposed to rationalize the exptl. outcome and the vicinal thiosulfonylation.

Synthesis published new progress about Alkynes, bromo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luo, Guoli; Liu, Yongchun; Ding, Na; Li, Xiaoxiao; Zhao, Zhigang published the artcile< Metal-Free C-H Functionalization of Allenamides: An Access to Branched Allylic Esters>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is branched allylic ester preparation allenamide acyloxylation functionalization carboxylic acid.

A regioselective acyloxylation with carboxylic acids at the proximal carbon of allenamides by an N-iodosuccinimide-mediated C-H functionalization is reported. The reaction proceeds rapidly, is scalable to a gram scale, and displays a broad substrate scope, providing an efficient and practical protocol for the synthesis of branched allylic esters. Notably, protected amino acids were tolerated under the reaction conditions and afforded allylic amino acid esters in moderate yields.

ACS Omega published new progress about Acyloxylation. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reddy, Raju Jannapu; Shankar, Angothu; Kumari, Arram Haritha published the artcile< An Efficient Sequential One-Pot Approach for the Synthesis of C3-Functionalized Imidazo[1,2-a]pyridines under Transition-Metal Free Conditions>, HPLC of Formula: 128-09-6, the main research area is imidazopyridine preparation; bromomethyl ketone aminopyridine thiosulfonate sulfenylation.

A metal-free sequential one-pot three-component protocol is described for the synthesis of C3-functionalized imidazo[1,2-a]pyridines. A successive construction of imidazo[1,2-a]pyridine I (R = 4-MeC6H4, 2-naphthyl, 2-thienyl, etc.; R1 = SMe, naphthalen-1-ylsulfanyl, pyridin-2-ylsulfanyl, etc.; X = H, 6-Br, 6-Cl, 7-Me, 8-Me) followed by iodine-catalyzed sulfenylation has been achieved in a one-pot operation from readily available α-bromomethyl ketones RC(O)CH2Br, 2-aminopyridines II and thiosulfonates R1S(O)2Ar (Ar = C6H5, 1-naphthyl, 2-thienyl, etc.). An immense array of 3-sulfenylimidazo[1,2-a]pyridines I was obtained in good to high yields. Also, the method is extended for the synthesis of C3-halogenated imidazo[1,2-a]pyridines I (R1 = Br, Cl) using sodium halides NaY in the presence of K2S2O8. Notably, the reaction between α-bromomethyl ketones and 2-aminopyridines in the presence of K2S2O8 to yields 3-bromo-2-aryl-imidazo[1,2-a]pyridines I (R1 = Br), thus implying α-bromomethyl ketones to be served as brominating agent. Overall, the present sequential one-pot protocol is straightforward, operationally simple, tolerates a broad range of functional groups, and is reliable for gram-scale experiments

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics