Reference of 1298031-93-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1298031-93-2, name is 6,8-Dichloro-2-methylimidazo[1,2-b]pyridazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of intermediate 2 (250 g), morpholine ([CAS 110-91-8], 103 g, 1190 mmol)and N,N-diisopropylethylamine ([CAS 7087-68-5], 208.7 g, 1623 mmol) in CH3CN (2000 mL) was refluxed for 5 h. Then, the reaction mixture was concentrated underreduced pressure and the residue was purified by column chromatography over silicagel (eluent: petroleum ether/ethyl acetate, 3/1) to give 70 g (22.4%) of intermediate 3 as a yellow solid.
The synthetic route of 6,8-Dichloro-2-methylimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; LECLERCQ, Laurent, Christian, L.; BARTOLOME-NEBREDA, Jose, Manuel; CONDE-CEIDE, Susana; VAN GOOL, Michiel, Luc, Maria; WO2014/9305; (2014); A1;,
Chloride – Wikipedia,
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