Category: 1303587-99-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1303587-99-6

Synthesis of 8-benzyl-2-chloro-7 , 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0457] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (3.5 mL) under argon atmosphere were added sodium hydride (28 mg, 1.16 mmol) and bromomethylbenzene (216 mg, 1.16 mmol) at 0 C. The reaction mixture was warmed to RT and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 40% EtOAc:hexane to afford 8-benzyl-2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (120 mg, 75%) as an off-white solid. 1H-NMR (DMSO-<, 500 MHz): delta 7.62 (s, 1H), 7.30-7.20 (m, 5H), 4.10-4.08 (m, 2H), 3.78 (t, 2H), 3.49-3.47 (m, 2H), 2.88 (t, 2H); LCMS: 275.8 (M+); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 mupiiota); RT 3.64 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.6). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1303587-99-6. Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1303587-99-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1303587-99-6 as follows.

Synthesis of 2-chloro-8-(3-chlorobenzyl)-7 , 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0455] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (1 mL) under argon atmosphere was added sodium hydride (27 mg, 1.16 mmol) at 0 C. After stirring for 10 mins, l-(bromomethyl)-3-chlorobenzene (92 mg, 0.70 mmol) was added to the reaction mixture at 0 C and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-chloro-8-(3- chlorobenzyl)-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (160 mg, 93%) as an off- white solid. 1H-NMR (CD3OD, 400 MHz): delta 7.61 (s, 1H), 7.39-7.22 (m, 4H), 4.52 (s, 2H), 4.20-4.18 (m, 2H), 3.53-3.50 (m, 2H); LCMS: 295.8 (M+1); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 muiotaeta); RT 3.79 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.5).

According to the analysis of related databases, 1303587-99-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks

Synthesis of2-chloro-8-(l-phenylethyl)-7, 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0454] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (2 mL) under argon atmosphere was added sodium hydride (27 mg, 1.16 mmol) at 0 C. After stirring for 10 mins, (1-bromoethyl) benzene (130 mg, 0.70 mmol) was added to the reaction mixture at 0 C and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-chloro-8-(l-phenylethyl)-7, 8-dihydro- 6H-pyrimido [5, 4-b] [1, 4] oxazine (140 mg, 87%) as an off-white solid. 1H-NMR (CD3OD, 400 MHz): delta 7.60 (s, 1H), 7.39-7.23 (m, 5H), 6.20-6.11 (m, 1H), 4.18-4.10 (m, 1H), 3.98- 3.91 (m, 1H), 3.50-3.41 (m, 1H), 3.10-3.02 (m, 1H), 1.60 (s, 3H); LCMS: 275.8 (M+l); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 mupiiota); RT 3.70 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.5).

The synthetic route of 1303587-99-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics