Adding a certain compound to certain chemical reactions, such as: 13065-93-5, name is N1-(4-Chlorophenyl)benzene-1,4-diamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13065-93-5, category: chlorides-buliding-blocks
[0201] Step 3. To a solution of Compound 8-D (0.4 g, 1.8 mmol) and Compound 8-E(0.31 g, 1.8 mmol) in isopropanol (8 mL) was added p-toluenesulfonic acid (0.36 g, 1.9 mmol). The mixture was sealed and heated in microwave at 120 C for 1 hour. Monitoring by thin layer chromatography (petrol ether: ethyl acetate= 1:1 and Rf at 0.6) showed that Compound 8-E was consumed. The mixture was diluted with saturated aqueous NaHCO3 (20 mL) and extracted with ethyl acetate (15 mL x 3). The organic layers were concentrated and the residue was purified by preparative HPLC to give the title compound (38 mg, 1.3%, combined with other 5 batches; purity 79% by HPLC) as a white solid. ?H NMR (400 MHz, DMSO) oe 6.94-6.96 (d, J= 8.4 Hz, 1H), 7.07-7.05 (d, J= 8.4 Hz, 1H), 7.17-7.19 (d, J = 8.8 Hz, 1H), 7.50-7.52 (d, J= 8.4 Hz, 1H), 8.14 (s, 1H), 8.80 (s, 1H), 10.19 (s, 1H). MS:302.9 (M+lj.
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Reference:
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; WO2014/26039; (2014); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics