Category: 13078-79-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 13078-79-0

Step iii) 3-(3-Chlorophenethylamino)-N-cyclohexyl-N-(2-(2-(8-hydroxy-2-oxo-l ,2- dihydroqumolin-5-yl)etliylamino)ethyl)rhoropanamide bis(trifluoroacetate)Benzyl 2-(N-cyclohexylacrylamido)ethyl(2-(8-hydroxy-2-oxo- 1 ,2-dihydroquinolin-5- yl)ethyl)carbamate (70 mg) [Step ii] and 2-(3-chlorophenyl)ethylamine (63 mg) were combined in ethanol (5.8 niL) and the resulting solution stirred at 50 0C for 18 h. The mixture was then concentrated in vacuo prior to addition of acetic acid (2 mL) followed by 33% HBr in acetic acid (3 mL). The resulting solution was stirred for 3 h then concentrated in vacuo and the residue partially purified by flash chromatography on silica (eluting with 10% methanol in dichloromethane). Product containaing fractions were combined and concentrated in vacuo. The residue was further purified by reverse phase preparative HPLC (eluting with 5-40% acetonitrile in 0.1% aqueous trifluoroacetic acid). Product containing fractions were combined and concentrated in vacuo to afford the title compound as a solid (5 mg) MS (APCI+) 539 [M+H]+1H NMR (399.825 MHz, CD3OD) delta 8.16 (d, J = 9.7 Hz5 IH)5 7.41 – 7.35 (m, 2H), 7.30 – 7.22 (m, 2H), 6.98 (dd, J = 22.2, 8.1 Hz52H), 6.66 (d, J= 10.0 Hz5 IH), 3.65 – 3.57 (m, 3H)5 3.38 – 3.27 (m, 4H), 3.23 – 3.14 (m, 8H), 2.91 (t, J = 6.0 Hz, 2H), 1.88 – 1.82 (m, 2H), 1.79 – 1.74 (m, 2H), 1.70 – 1.63 (m, IH), 1.56 – 1.26 (m, 4H), 1.22 – 1.09 (m, IH).

The synthetic route of 13078-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/75025; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

13078-79-0, The chemical industry reduces the impact on the environment during synthesis 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, I believe this compound will play a more active role in future production and life.

General procedure: A solution of 24 (1.0 equiv.), HOBt (1.1 equiv.) and EDC (1.5 equiv.) in DMF (1.3 mmol/mL) was stirred at rt for 15 minutes. The appropriate amine (2.0 equiv.) was added and the resulting solution was stirred at rt for 5 hours. Reaction media was diluted with water and aqueous phase was extracted 3 times with EtOAc. Combined organic layers were washed successively with a solution of HCl 1N, a saturated solution of NaHCO3 and brine, dried over Na2SO4 and concentrated. The resulting solid was then purified by column chromatography on silica gel using the appropriate heptanes:EtOAc mixture.

The chemical industry reduces the impact on the environment during synthesis 2-(3-Chlorophenyl)ethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Bollenbach, Maud; Lugnier, Claire; Kremer, Melanie; Salvat, Eric; Megat, Salim; Bihel, Frederic; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 269 – 290;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

13078-79-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3-Hydroxy-4-(4-methyl-1/-/-imidazol-1-yl)benzoic acid, hydrobromide salt from the previous experiment (300 mg, 1.00 mmol) was combined with 2-(3-chlorophenyl)ethanamine (321 mg, 2.06 mmol), 1/-/-benzotriazol-1-ol (HOBT, 279 mg, 2.06 mmol), diisopropylethylamine (0.94 ml_, 5.50 mmol) in dimethylformamide (6.9 ml_)and the mixture was stirred until dissolved. Lambda/-[3- (dimethylamino)propyl]-Lambda/’-ethylcarbodiimide hydrochloride (EDCI, 320 mg, 2.06 mmol) was added, and the reaction was stirred for 18 hours. The reaction mixture was poured into water (100 ml_) and extracted with ethyl acetate (3 x 100 ml_). The combined organic layers were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Chromatography on silica (Mobile phase A: ethyl acetate; Mobile phase B: 9:1 ethyl acetate: [2M ammonia in methanol]; Gradient: 50%B to 100%B) afforded the title compound. Yield: 280 mg, 0.787 mmol, 77%. LCMS m/z 356.1 , 358.1 (M+1 ). 1H NMR (400 MHz, CD3OD) delta 2.24 (br s, 3H), 2.91 (t, J=7.3 Hz, 2H), 3.58 (t, J=7.3 Hz, 2H), 7.16-7.22 (m, 3H), 7.25-7.30 (m, 3H), 7.37 (d, J=8.3 Hz, 1 H), 7.44 (d, J=1.9 Hz, 1 H), 7.94 (d, J=1.2 Hz, 1 H).

The synthetic route of 13078-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; ALLEN, Martin, Patrick; AM ENDE, Christopher, William; BRODNEY, Michael, Aaron; DOUNAY, Amy, Beth; JOHNSON, Douglas, Scott; PETTERSSON, Martin, Youngjin; SCHWARZ, Jacob, Bradley; TRAN, Tuan, Phong; WO2010/100606; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics