Category: 13078-80-3

Related Products of 13078-80-3,Some common heterocyclic compound, 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1 Into a 100 ml reaction flask equipped with a condenser, a thermometer and a stirrer, 15.56 g (0.1 mol) of 2-chlorophenethylamine, 22.0 g (0.11 mol) of a 20% sodium hydroxide aqueous solution and 0.176 g (0.5 mol %) of quinoline copper were charged, and reacted at 110 C. for 8 hours. The reaction mixture thereby obtained was subjected to liquid separation to separate the aqueous layer from the organic layer. The organic layer was washed with an acid and distilled to obtain 11.4 g of indoline (boiling point: 94-95 C./11 mmHg). The purity was 99.5%, and the yield was 96%.

The synthetic route of 13078-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ihara Chemical Industry Co., Ltd.; US4673749; (1987); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 13078-80-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Propyl N-cyano-6-amino-3-pyridinecarboximidate (200 mg, 0.98 mmol) and 2-(2-chlorophenyl)ethylamine (170 mg, 1.09 mmol) were dissolved in a mixture of methanol (10 ml) and DMF (1.5 ml), and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure and subjected to silica gel column chromatography (Wako Gel C-200, 25 g), and elution was conducted with chloroform:methanol (30:1) to give the title compound (250 mg, yield 85%) as colorless powder. Mp 222 C. IR (KBr) cm-1:3220, 2160, 1570, 740. 1 H-NMR (90 MHz, DMSO): delta (ppm) 8.91(1Hr brs, NH), 8.13(1H, d, J=2.5Hz, H-6), 7.60(1H, dd, J=2.5, 8.6Hz, H-4), 7.45-7.2(4H, C6 H4 Cl), 6.60(2H, brs, NH2), 6.48(1H, d, J=8.6Hz, H-3), 3.56(2H, m, NHCH2 CH2 C6 H4 Cl), 3.02(2H, t, J=7.0Hz, NHCH2 CH2 C6 H4 Cl).

The synthetic route of 2-(2-Chlorophenyl)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kirin Beer Kabushiki Kaisha; US5508293; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13078-80-3, Quality Control of 2-(2-Chlorophenyl)ethanamine

N-(2-Fluoropyrimidin-4-yl)-N-methyl-2-phenylpyrimidin-4-amine (442 mg, 1.5 mmol), 2-(2-chlorophenyl)ethanamine (0.32 mL, 2.25 mmol), and dioxane (7 mL) were mixed in a 25 mL roundbottom flask. The mixture was stirred at 100 C. overnight under nitrogen. The reaction was concentrated by vacuum and quenched with saturated NaHCO3 solution. The white solid was filtered and recrystallized to give N2-(2-chlorophenethyl)-N4-methyl-N4-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine as a white solid. MS m/z 417 (MH)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Chlorophenyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 13078-80-3,Some common heterocyclic compound, 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1 Into a 100 ml reaction flask equipped with a condenser, a thermometer and a stirrer, 15.56 g (0.1 mol) of 2-chlorophenethylamine, 22.0 g (0.11 mol) of a 20% sodium hydroxide aqueous solution and 0.176 g (0.5 mol %) of quinoline copper were charged, and reacted at 110 C. for 8 hours. The reaction mixture thereby obtained was subjected to liquid separation to separate the aqueous layer from the organic layer. The organic layer was washed with an acid and distilled to obtain 11.4 g of indoline (boiling point: 94-95 C./11 mmHg). The purity was 99.5%, and the yield was 96%.

The synthetic route of 13078-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ihara Chemical Industry Co., Ltd.; US4673749; (1987); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 13078-80-3

The following compounds of the formula lb listed in Table 1 were prepared analogously to Example 1 using the corresponding amine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13078-80-3, its application will become more common.

Reference:
Patent; Aventis Pharma Deutschland GmbH; US6344468; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 13078-80-3,Some common heterocyclic compound, 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-7- (3-chloropyridin-2-yl)-2- [ (R, R) -2, 6-dimethylmorpholin4-ylmethyl]-quinazoline (30mg, 0. 074mmol) is dissolved in 1. 6mL CH3CN. 2-(2-Chlorophenyl) ethylamine (13mg, 0. 081mmol) is added and the reaction mixture is heated at 80C until the starting chloride is consumed. Upon cooling to room temperature, the reaction mixture is concentrated in vacuo. The residue is diluted with EtOAc and washed with 10% NaOH solution. The organic phase is concentrated and the product purified by preparative TLC, eluting with 9/1 CH2Cl2/MeOH to afford [2- (2-chlorophenyl) ethyl]- [7- (3-cl-iloropyridin-2-yl)-2- ( (R, R) -2, 6-dimethyhnorpholin-4-ylmethyl)- quinazolin-4-yl]-amine.’H NMR 8 : (CDC13, recorded on Gemini 300MHz NMR) 8.63 (dd, 1H, J=4.6Hz, J=1. 6Hz), 8.23 (d, 1H, J=1. 4Hz), 7.84 (dd, 1H, J=7.9Hz, J=1. 4Hz), 7.73 (dq, 2H, J=8. 5Hz, J=1. 6Hz), 7.40 (dd, 1H, J=5. 5Hz, J=4. 1Hz), 7.41-7. 12 (m, 3H), 5.85 (br s, 1H), 4.13-4. 06 (m, 2H), 3.99 (q, 1H, J=6. 5Hz), 3.83 (d, 1H, J=14. 0Hz), 3.65 (d, 1H, J=14. 0Hz), 3.21 (t, 2H, J=6.8Hz), 2.70 (dd, 2H, J=11. 3Hz, J=3.3Hz), 2.46 (dd, 2H, J=11.3Hz, J=5.8Hz), 1. 27 (d, 6H, J=8.3Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Chlorophenyl)ethanamine, its application will become more common.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/87227; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics