Category: 13334-71-9

Some common heterocyclic compound, 13334-71-9, name is 4-Chloro-3-methylanisole, molecular formula is C8H9ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H9ClO

A solution of 4-chloro-3-methylanisole (3.0 g, 19.2 mmol) (Acros) and potassium permanganate (7.57 g, 47.9 mmol) in water (60 ML) was heated at reflux for 4 h.The precipitate was filtered and the solution was extracted with EtOAc. The aqueous phase was acidified with conc. HCl. The precipitate was collected by filtration, washed with water and dried to give the product. (Yield 0.78 g, 22%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13334-71-9, its application will become more common.

Reference:
Patent; Chen, Jian Jeffrey; Luk, Kin-Chun Thomas; US2004/97493; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13334-71-9, name is 4-Chloro-3-methylanisole, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13334-71-9, category: chlorides-buliding-blocks

To a solution of the l-chloro-4-methoxy-2-methylbenzene (2.0 g, 12.77 mmol) in anhydrous carbon tetrachloride (50 mL), NBS (2.29 g, 12.98 mmol) and benzoyl peroxide (0.154 g, 0.64 mmol) was added. The reaction mixture was heated to reflux overnight. Then, the reaction mixture was cooled to room temperature and filtered. The filtrate was evaporated to provide crude 2-(bromomethyl)-l-chloro-4- methoxybenzene, which was used for the next step without any further purification; 1H NMR (400 MHz, DMSO-J6): delta 3.74 (s, 3H), 4.66 (s, 2H), 7.01 (d, J = 8.9 Hz, IH), 7.19 (s, IH), 7.38 (d, J = 8.9 Hz, IH).

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics