In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136773-69-8, name is 4-Chloro-7-fluoropyrrolo[1,2-a]quinoxaline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Chloro-7-fluoropyrrolo[1,2-a]quinoxaline
A mixture of 7-fluoro-4-chloropyrrolo[1,2-alpha]quinoxaline 13c (100 mg, 0.45 mmol), hydrazine monohydrate (5 mL), and DMF (2 mL) was heated to 70-80 C. for 1 h. Crushed ice was then added and the mixture was extracted with EtOAc. The organic layer was separated and shaken with water and brine successively. After evaporation of the volatiles, compound 14c was obtained as a solid (84 mg, 86% yield) and used in the subsequent step without further purification. An analytical sample was obtained by crystallization; mp 158 C. (dec.) (dichloromethane/light petroleum); IR (KBr) 3300 cm-1; 1H NMR (DMSO-d6) 4.56 (bs, 2 H), 6.66 (t, 1 H, J=3.2 Hz), 7.03 (m, 2 H), 7.18 (dd, 1 H, J=10.6, 2.7 Hz), 8.02 (dd, 1 H, J=8.9, 5.6Hz), 8.15 (s, 1 H), 8.87 (bs, 1 H). Anal. Calcd for C11H9FN4: C, H, N.
The synthetic route of 136773-69-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; University of Southern California; US2006/142294; (2006); A1;,
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