Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 137384-48-6, name is 6-Chloro-3-methylimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 6-Chloro-3-methylimidazo[1,2-b]pyridazine
To 0.835 mmol of (S)-2-(4-methyl-1-(2-oxo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-pyridin-1(2H)-yl)pentan-2-yl)isoindoline-1,3-dione in a microwaveable vial was added100 mg (0.597 mmol) of 6-chloro-3-methylimidazo[1,2-b]pyridazine, 98 mg (0.119 mmol) ofPdCI2(dppf)2.DCM, 2 mL of DME, and 2 mL of 2M KOAc aqueous solution. It was microwaved at 135C for 0.5 hr. It was diluted with EtOAc, washed with brine, filtered through a pad of celite in order to distinguish between the organic and aqueous layers. The organic layer was dried over MgSO4, concentrated and loaded onto a 40 gram silica gel column and purified on the ISCO eluting with 0-10% MeOH/DCM to obtain the desired. This product was subjected to the phthalimides deprotection procedure described in Example 5.6.28 to obtain the titled5 compound. 1H NMR (400 MHz, METHANOL-d4) ppm 1.02 (d, J=6.57 Hz, 3 H) 1.06 (d,J=6.57 Hz, 3 H) 1.54 – 1.67 (m, 2 H) 1.80 – 1.91 (m, 1 H) 2.66 (5, 3 H) 3.79 (qd, J=7.24,3.79 Hz, 1 H) 4.26 (dd, J=14.27, 7.71 Hz, 1 H) 4.36 (dd, J=14.40, 3.79 Hz, 1 H) 7.23 (dd,J=7.20, 1.89 Hz, 1 H) 7.29 (d, J=1.77 Hz, 1 H) 7.68 (5, 1 H) 7.75 – 7.83 (m, 2 H) 8.11 (d,J=9.60 Hz, 1 H). LRMS (ESI) m/z 326 [(M+H)], calc?d for C18H23N05: 325.
According to the analysis of related databases, 137384-48-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; GARDYAN, Michael Walter; GREEN, Michael Alan; GODWIN, Kumi; ZHANG, Yulian; WO2015/35167; (2015); A1;,
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